Artemisinin mimics calorie restriction to trigger mitochondrial biogenesis and compromise telomere shortening in mice

Calcium ion as cellular messenger

(2015) Jie Zheng et al.   Science China-Life Sciences

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

(2014) Randall M. Chin et al.   NATURE

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

(2014) W. De Haes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity

(2013) Elsa Vera et al.   PLoS One

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Aspirin may promote mitochondrial biogenesis via the production of hydrogen peroxide and the induction of Sirtuin1/PGC-1α genes

(2012) Pratibha Kamble et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nitric Oxide-Driven Hypoxia Initiates Synovial Angiogenesis, Hyperplasia and Inflammatory Lesions in Mice

(2012) Fei Bao et al.   PLoS One

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1

(2012) Serena L. Clark et al.   Computational and Structural Biotechnology Journal

Mild Mitochondrial Uncoupling and Calorie Restriction Increase Fasting eNOS, Akt and Mitochondrial Biogenesis

(2011) Fernanda M. Cerqueira et al.   PLoS One

l-Arginine restores endothelial nitric oxide synthase-coupled activity and attenuates monocrotaline-induced pulmonary artery hypertension in rats

(2010) Zhi-Jun Ou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Artesunate mitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthase

(2010) Qing-Ping Zeng et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity

(2010) A. Mesquita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

(2010) Valter D. Longo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR

(2010) M V Blagosklonny   Cell Death & Disease

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Caloric restriction: From soup to nuts

(2009) Stephen R. Spindler   AGEING RESEARCH REVIEWS

Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan

(2009) Dickon M. Humphrey et al.   EXPERIMENTAL GERONTOLOGY

BRCA1 Localization to the Telomere and Its Loss from the Telomere in Response to DNA Damage

(2009) Rahul D. Ballal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C. elegans longevity pathways converge to decrease mitochondrial membrane potential

(2009) Bernard D. Lemire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial function as a determinant of life span

(2009) Ian R. Lanza et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Heme Mediates Cytotoxicity from Artemisinin and Serves as a General Anti-Proliferation Target

(2009) Shiming Zhang et al.   PLoS One

Metabolic reprogramming, caloric restriction and aging

(2009) Rozalyn M. Anderson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Aging and dietary restriction effects on ubiquitination, sumoylation, and the proteasome in the heart

(2008) Feng Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT