Article
Microbiology
Carlos A. Guerrero-Bustamante, Rebekah M. Dedrick, Rebecca A. Garlena, Daniel A. Russell, Graham F. Hatfull
Summary: Research suggests using bacteriophages may be a promising strategy for treating tuberculosis, with a five-phage cocktail effectively killing Mycobacterium tuberculosis strains without affecting antibiotic effectiveness. This offers new possibilities for treating tuberculosis and combating antibiotic resistance.
Review
Microbiology
Graham F. Hatfull
Summary: Mycobacteriophages play a significant role in understanding viral diversity and evolution. They provide resources and tools for advancing Mycobacterium genetics and show potential in therapeutic applications. Experimental studies with the model organism Mycobacterium smegmatis have provided high-resolution insights into the phages that infect common host strains.
Review
Biochemistry & Molecular Biology
Anna Allue-Guardia, Rajagopalan Saranathan, John Chan, Jordi B. Torrelles
Summary: The review discusses the features and mechanisms of action of mycobacteriophages for treating drug-resistant tuberculosis, as well as the advantages and limitations. It also highlights the need to address key issues in the clinical application of phage therapy for drug-resistant tuberculosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Microbiology
Sepideh Hosseiniporgham, Leonardo A. Sechi
Summary: Mycobacterial infections caused by fast- or slow-growing bacteria are life-threatening conditions. The challenges in diagnosing and treating these infections are influenced by the unique cell wall structure of mycobacteria. Using mycobacteriophages as viruses that infect mycobacteria can accelerate the diagnosis and treatment, but further research is needed.
Review
Respiratory System
Andreas H. Diacon, Carlos A. Guerrero-Bustamante, Bernd Rosenkranz, Francisco J. Rubio Pomar, Naadira Vanker, Graham F. Hatfull
Summary: Global antimicrobial resistance rates are increasing while new antibiotics are in short supply, posing risks for patients with diseases caused by drug-resistant bacteria. Bacteriophages are viruses that attack bacteria and can be used to prevent contamination by human pathogens.
Review
Microbiology
Xudong Ouyang, Xiaotian Li, Jinmiao Song, Hui Wang, Shuxian Wang, Ren Fang, Zhaoli Li, Ningning Song
Summary: This article introduces the potential clinical applications of mycobacteriophages, including phage-based diagnosis and treatment of mycobacterial infections. It also summarizes the current difficulties in phage therapy and provides insights into new treatment strategies against drug-resistant mycobacteria.
FRONTIERS IN MICROBIOLOGY
(2023)
Editorial Material
Cell Biology
Ryan A. Canfield, Amy L. Orsborn, Gregory D. Horwitz
Summary: The calcium imaging of neurons in monkeys performing reaches is hindered by brain movements and shallow imaging depth. In a pair of recent studies, Trautmann et al., 2021 and Bollimunta et al. (2021) present complementary solutions to these challenges.
Editorial Material
Neurosciences
Phan Q. Duy, Pasko Rakic, Seth L. Aper, William E. Butler, Christopher A. Walsh, Nenad Sestan, Daniel H. Geschwind, Sheng Chih Jin, Kristopher T. Kahle
Summary: Dilation of fluid-filled cerebral ventricles, known as ventriculomegaly, is a common feature of hydrocephalus and is often seen in autism and schizophrenia. Recent research indicates that studying the genomics of congenital hydrocephalus may provide valuable insights into neural stem cell regulation, human cerebrocortical development, and the pathogenesis of neuropsychiatric diseases.
Article
Biochemistry & Molecular Biology
Thibault Leroy, Marjolaine Rousselle, Marie-Ka Tilak, Aude E. Caizergues, Celine Scornavacca, Maria Recuerda, Jerome Fuchs, Juan Carlos Illera, Dawie H. De Swardt, Guillermo Blanco, Christophe Thebaud, Borja Mila, Benoit Nabholz
Summary: This study confirms that island species have lower census population sizes and effective population sizes, resulting in lower nucleotide diversity in coding regions, higher ratios of non-synonymous to synonymous polymorphisms, and lower adaptive substitution rates.
Editorial Material
Microbiology
Mark R. Sullivan, Eric J. Rubin, Charles L. Dulberger
Summary: Mycobacterium abscessus (Mab) is highly tolerant to current antibiotic therapies, leading to a high failure rate of standard care. Phages may offer a promising alternative treatment with few side effects. Two studies shed light on the natural phage complement of Mab and the factors that may drive susceptibility to these phages, paving the way for more effective phage therapy development.
Article
Virology
Christian Cambillau, Adeline Goulet
Summary: This study investigates the structure of host-binding machineries of seven representative mycobacteriophages infecting Mycobacterium smegmatis, Mycobacterium abscessus, and Mycobacterium tuberculosis using AlphaFold2. The results reveal unique features in the host-binding machineries of these mycobacteriophages, potentially related to the specific mycobacterial cell envelope rich in polysaccharides and mycolic acids. This work provides a rational framework for efficient production of recombinant proteins and testing their host-binding function.
JOURNAL OF VIROLOGY
(2023)
Article
Physics, Multidisciplinary
Stephen F. King, Silvia Pascoli, Jessica Turner, Ye-Ling Zhou
Summary: The text discusses the relationship between proton decay and gravitational waves, as well as their importance for grand unified theories and the standard model. Experimental evidence may help identify preferred symmetry-breaking routes to SO(10).
PHYSICAL REVIEW LETTERS
(2021)
Article
Physics, Particles & Fields
Ben Craps, Juan Hernandez, Mikhail Khramtsov, Maria Knysh
Summary: We revisit the model of an AdS(2) black hole in JT gravity evaporating into an external bath. We study when, and how much, information about the black hole interior can be accessed through different portions of the Hawking radiation collected in the bath, and we obtain the corresponding full quantitative Page curves. We also discuss the evolution of the subregion complexity of the radiation during the black hole evaporation.
JOURNAL OF HIGH ENERGY PHYSICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Wesley J. Transue, Yizhe Dai, Martin-Louis Y. Riu, Gang Wu, Christopher C. Cummins
Summary: A series of octamethylcalix[4]pyrrole/ruthenium phosphinidene complexes were synthesized, and their P-31 chemical shifts were studied using solid-state nuclear magnetic resonance spectroscopy and density functional theory. The results revealed that the degree of deshielding controls the isotropic chemical shifts of P-31 in the complexes, which is related to the local ruthenium/phosphorus electronic structure.
INORGANIC CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Filipa Santos, David Pires, Elsa Anes, Ana Rita C. Duarte
Summary: This study evaluated the stability and antibacterial activity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. The results showed that these mixtures have antibacterial effects against drug-susceptible Mycobacterium tuberculosis strains, with the mixtures incorporating ethambutol showing particularly prominent effects. The findings suggest the potential for further research and evaluation of clinical applicability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
