Journal
MEMORIAS DO INSTITUTO OSWALDO CRUZ
Volume 104, Issue -, Pages 226-235Publisher
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762009000900029
Keywords
Chagas disease; Trypanosoma cruzi; cardiomyopathy; chemokine; chemokine receptors; cell adhesion molecules
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One hundred years ago, Carlos Chagas discovered a new disease, the American trypanosomiasis. Chagas and co-workers later characterised the disease's common manifestation, chronic cardiomyopathy, and suggested that parasitic persistence coupled with inflammation was the key underlying pathogenic mechanism. Better comprehension of the molecular mechanisms leading to clinical heart afflictions is a prerequisite to developing new therapies that ameliorate inflammation and improve heart function without hampering parasite control. Here, we review recent data showing that distinct cell adhesion molecules, chemokines and chemokine receptors participate in anti-parasite immunity and/or detrimental leukocyte trafficking to the heart. Moreover, we offer evidence that CC-chemokine receptors may be attractive therapeutic targets aiming to regain homeostatic balance in parasite/host interaction thereby improving prognosis, supporting that it is becoming a non-phantasious proposal.
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