Statins Decrease Neuroinflammation and Prevent Cognitive Impairment after Cerebral Malaria

Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model

(2012) Jean-Baptiste Souraud et al.   MALARIA JOURNAL

PPAR gamma activation protects the brain against microvascular dysfunction in sepsis

(2012) C.V. Araújo et al.   MICROVASCULAR RESEARCH

The Role of Animal Models for Research on Severe Malaria

(2012) Alister G. Craig et al.   PLoS Pathogens

The Neuropathology of Fatal Cerebral Malaria in Malawian Children

(2011) Katerina Dorovini-Zis et al.   AMERICAN JOURNAL OF PATHOLOGY

Statins and Brain Dysfunction

(2011) Alessandro Morandi et al.   CHEST

Mechanisms for the anti-inflammatory effects of statins

(2011) De-xiu Bu et al.   CURRENT OPINION IN LIPIDOLOGY

Statins in prevention and treatment of severe sepsis and septic shock

(2011) I. Kouroumichakis et al.   European Journal of Internal Medicine

Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage

(2011) Zacharie Taoufiq et al.   MALARIA JOURNAL

The relevance of non-human primate and rodent malaria models for humans

(2011) Jean Langhorne et al.   MALARIA JOURNAL

Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III

(2010) C.C. McGown et al.   BRITISH JOURNAL OF ANAESTHESIA

Persistent cognitive impairment after cerebral malaria: models, mechanisms and adjunctive therapies

(2010) Guy A Zimmerman et al.   Expert Review of Anti-Infective Therapy

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene

(2010) N. Wurtz et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Systemic infection and delirium: when cytokines and acetylcholine collide

(2010) Willem A van Gool et al.   LANCET

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

(2010) S. H. I. Kappe et al.   SCIENCE

Murine cerebral malaria: the whole story

(2010) Nicholas H. Hunt et al.   TRENDS IN PARASITOLOGY

Murine cerebral malaria: how far from human cerebral malaria?

(2010) Leonardo J.M. Carvalho   TRENDS IN PARASITOLOGY

Cognitive Dysfunction Is Sustained after Rescue Therapy in Experimental Cerebral Malaria, and Is Reduced by Additive Antioxidant Therapy

(2010) Patricia A. Reis et al.   PLoS Pathogens

Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins Is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow

(2009) Faisal Ali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Antihypertensive Drugs on Capillary Rarefaction in Spontaneously Hypertensive Rats: Intravital Microscopy and Histologic Analysis

(2009) Bruno Sabino et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease

(2009) J. BRIAN de SOUZA et al.   PARASITOLOGY

IP-10-Mediated T Cell Homing Promotes Cerebral Inflammation over Splenic Immunity to Malaria Infection

(2009) Catherine Q. Nie et al.   PLoS Pathogens

Statins Alone Are Ineffective in Cerebral Malaria but Potentiate Artesunate

(2008) A.-L. Bienvenu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism

(2008) Alexander Semmler et al.   Journal of Neuroinflammation

Effect of Rosuvastatin on Amnesia and Disorientation after Traumatic Brain Injury (NCT00329758)

(2008) J. Humberto Tapia-Perez et al.   JOURNAL OF NEUROTRAUMA

Artesunate for the Treatment of Severe Falciparum Malaria

(2008) Philip J. Rosenthal   NEW ENGLAND JOURNAL OF MEDICINE

Cerebral Malaria in Children Is Associated With Long-term Cognitive Impairment

(2008) C. C. John et al.   PEDIATRICS