Article
Public, Environmental & Occupational Health
Yushi Lin, Kailu Fang, Yang Zheng, Hong-liang Wang, Jie Wu
Summary: This study aimed to assess the global burden and trends of neglected tropical diseases (NTDs) from 1990 to 2019. The results showed that the age-standardized incidence rate (ASIR) and number of incident cases of total NTDs increased globally, while the mortality rate and DALYs decreased. Tropical Latin America was the only region to experience a decreasing trend in ASIR. Children and older adults were vulnerable to certain diseases, and females had a higher incidence rate but lower mortality rate and DALY rate.
JOURNAL OF TRAVEL MEDICINE
(2022)
Review
Chemistry, Analytical
Tais Aparecida Reis Cordeiro, Mayra Asevedo Campos de Resende, Simone Cristina dos Santos Moraes, Diego Leoni Franco, Arnaldo Cesar Pereira, Lucas Franco Ferreira
Summary: Neglected tropical diseases are a group of infectious and parasitic diseases prevalent in tropical and subtropical regions, with limited access to proper healthcare. The development of low-cost biosensors for fast diagnosis in these areas is crucial for better treatment and eradication. While progress has been made in the past decade, challenges remain in early detection of neglected tropical diseases using biosensors.
Review
Rheumatology
Rasmi Ranjan Sahoo, Anupam Wakhlu, Vikas Agarwal
Summary: Dealing with rheumatic diseases in tropical countries is complex due to limited healthcare infrastructure, lack of diagnostic and therapeutic facilities, impact of dominant prevalent diseases, and challenges in differentiating from infectious and non-infectious disease mimics. Several tropical diseases present with musculoskeletal and rheumatic manifestations, leading to delayed diagnosis or misdiagnosis and poor patient outcomes.
CLINICAL RHEUMATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Yi Xie, Dandan Shi, Xu Wang, Yayi Guan, Weiping Wu, Ying Wang
Summary: This study investigated the parasitic diseases of neglected tropical diseases in China from 1990 to 2019. The analysis focused on the prevalence and burden of these diseases, aiming to provide valuable information for better management and prevention. The findings showed a decrease in the prevalence and burden of neglected parasitic diseases in China, but there are still many issues to be addressed. Further efforts are needed to improve prevention and control strategies, with a focus on prioritizing diseases with a high burden.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Medicine, General & Internal
Agumasie Semahegn, Tsegahun Manyazewal, Eyerusalem Getachew, Bethelhem Fekadu, Esubalew Assefa, Munir Kassa, Gail Davey, Michael Hopkins, Mesele Araya, Tassew Woldehanna, Charlotte Hanlon, Abebaw Fekadu
Summary: More than 1.7 billion people worldwide are affected by neglected tropical diseases (NTDs), with a high burden of these diseases in Africa. The World Health Organization aims to prevent, control, eliminate, or eradicate 20 tropical diseases. However, little is known about the access to diagnostics, medicine, and/or care in Ethiopia. This scoping review explores the burden of NTDs and challenges in access to diagnostics, medicine, and/or care in Ethiopia.
SYSTEMATIC REVIEWS
(2023)
Article
Immunology
Hollie-Ann Hatherell, Hope Simpson, Rebecca F. Baggaley, T. Deirdre Hollingsworth, Rachel L. Pullan
Summary: The WHO's 2030 road map for neglected tropical diseases highlights the importance of strengthened, institutionalized post-elimination surveillance, but lacks practical guidance on implementation. Nationally representative survey programs, such as DHS, may provide a platform for integrating disease surveillance within national health systems, with a focus on maximizing utility and addressing priorities for further data collection and characterization.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Pharmacology & Pharmacy
Rachel H. Clare, Steven R. Hall, Rohit N. Patel, Nicholas R. Casewell
Summary: Snakebite envenoming causes up to 138,000 deaths annually, making it the deadliest neglected tropical disease. Current treatment with biologic antivenoms is outdated and expensive, but there is great potential in developing small molecule drugs to inhibit venom toxins. Strategies successful in treating other NTDs could be utilized to facilitate the development of next-generation snakebite treatments.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Immunology
Martin Walker, Jonathan I. D. Hamley, Philip Milton, Frederic Monnot, Sally Kinrade, Sabine Specht, Belen Pedrique, Maria-Gloria Basanez
Summary: Drug-based interventions are crucial in addressing major diseases, with a growing consensus on the need for new therapeutic options in some cases. In this field, minimizing wastage of money and resources is essential.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Wendemagegn Enbiale, Alemayehu Bekele, Nigus Manaye, Fikre Seife, Zeyede Kebede, Filmon Gebremeskel, Johan van Griensven
Summary: Subcutaneous mycoses are endemic in Ethiopia, with cases reported throughout the country, especially in the northern regions. The lack of research and surveillance programs for these diseases highlights the need for routine programs and systems to identify and record cases.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Kush K. Maheshwari, Debasish Bandyopadhyay
Summary: NTDs affect a vast population, mainly in developing countries, with WHO identifying 20 priority diseases. Heterocyclic drugs show promising therapeutic activity against NTDs. The study aims to raise awareness, discuss treatment options, and highlight the need for further research on NTDs.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Leonardo L. G. Ferreira, Josue de Moraes, Adriano D. Andricopulo
Summary: Neglected tropical diseases, such as leishmaniasis and schistosomiasis, continue to be a public health challenge in developing countries. However, advancements in drug discovery using modern strategies have shown promise in addressing these diseases by combining medicinal chemistry and parasite biology.
DRUG DISCOVERY TODAY
(2022)
Article
Immunology
Amanda Minter, Lorenzo Pellis, Graham F. Medley, T. Deirdre Hollingsworth
Summary: As countries strive to meet WHO goals for reducing morbidity and eliminating disease transmission, they will need to plan for the next stages of surveillance and control in low prevalence settings. Going beyond simple predictions of treatment program effectiveness, more nuanced intervention choices informed by quantitative analyses will be necessary for sustainable gains in the long term. Identifying policy goals and finding the right balance between intervention and surveillance constraints will be key challenges in achieving multiple aims such as minimizing morbidity and costs simultaneously.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Theresa W. Gyorkos, Helene Carabin, Maneesh Phillip, Leshawn Benedict, Amy Davis, Janet Hatcher Roberts, Kishor M. Wasan, Momar Ndao, Alison Krentel
Summary: Canadian researchers have published over 160 publications per year on neglected tropical diseases between 2010 and 2019, covering all 20 NTDs. The most commonly studied diseases were leishmaniasis, dengue fever, chikungunya, Chagas disease, soil-transmitted helminthiases, and rabies.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Immunology
Jaspreet Toor, Emily R. Adams, Maryam Aliee, Benjamin Amoah, Roy M. Anderson, Diepreye Ayabina, Robin Bailey, Maria-Gloria Basanez, David J. Blok, Seth Blumberg, Anna Borlase, Rocio Caja Rivera, Maria Soledad Castano, Nakul Chitnis, Luc E. Coffeng, Ronald E. Crump, Aatreyee Das, Christopher N. Davis, Emma L. Davis, Michael S. Deiner, Peter J. Diggle, Claudio Fronterre, Federica Giardina, Emanuele Giorgi, Matthew Graham, Jonathan I. D. Hamley, Ching- Huang, Klodeta Kura, Thomas M. Lietman, Tim C. D. Lucas, Veronica Malizia, Graham F. Medley, Aronrag Meeyai, Edwin Michael, Travis C. Porco, Joaquin M. Prada, Kat S. Rock, Epke A. Le Rutte, Morgan E. Smith, Simon E. F. Spencer, Wilma A. Stolk, Panayiota Touloupou, Andreia Vasconcelos, Carolin Vegvari, Sake J. de Vlas, Martin Walker, T. Deirdre Hollingsworth
Summary: The COVID-19 pandemic has led to the postponement of key neglected tropical disease activities, hindering progress towards the ambitious goals for 2030. Mathematical modelling indicates that the impact of this disruption will vary across different NTDs, with a risk of resurgence being fastest in high-transmission areas.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Chemistry, Medicinal
Igor Jose dos Santos Nascimento, Misael de Azevedo Teotonio Cavalcanti, Ricardo Olimpio de Moura
Summary: Neglected tropical diseases (NTDs) are a group of infectious diseases that mainly affect impoverished populations in tropical countries. They cause many deaths worldwide and require substantial investments in public health to treat and control them. Protozoan diseases such as Chagas disease, sleeping sickness, and Leishmaniasis, as well as the big three diseases (AIDS, tuberculosis, and malaria), are endemic in tropical countries. However, there is still a gap in treatment, emphasizing the need for new alternatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Public, Environmental & Occupational Health
Sarah M. Gunter, Kathryn M. Jones, Bin Zhan, Heather T. Essigmann, Kristy O. Murray, Melissa N. Garcia, Rodion Gorchakov, Maria Elena Bottazzi, Peter J. Hotez, Eric L. Brown
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2016)
Review
Medicine, Research & Experimental
Peter J. Hotez, Maria Elena Bottazzi, Ulrich Strych
ANNUAL REVIEW OF MEDICINE, VOL 67
(2016)
Article
Immunology
Sarah M. Bartsch, Peter J. Hotez, Daniel L. Hertenstein, David J. Diemert, Kristina M. Zapf, Maria Elena Bottazzi, Jeffrey M. Bethony, Shawn T. Brown, Bruce Y. Lee
Article
Immunology
Peter J. Hotez, Coreen M. Beaumier, Portia M. Gillespie, Ulrich Strych, Tara Hayward, Maria Elena Bottazzi
Article
Immunology
Portia M. Gillespie, Coreen M. Beaumier, Ulrich Strych, Tara Hayward, Peter J. Hotez, Maria Elena Bottazzi
Editorial Material
Immunology
Peter J. Hotez, Ulrich Strych, Sara Lustigman, Maria Elena Bottazzi
Article
Immunology
Coreen M. Beaumier, Portia M. Gillespie, Ulrich Strych, Tara Hayward, Peter J. Hotez, Maria Elena Bottazzi
Article
Immunology
Maureen Merrifield, Peter J. Hotez, Coreen M. Beaumier, Portia Gillespie, Ulrich Strych, Tara Hayward, Maria Elena Bottazzi
Article
Biotechnology & Applied Microbiology
Elissa M. Hudspeth, Qian Wang, Christopher A. Seid, Molly Hammond, Junfei Wei, Zhuyun Liu, Bin Zhan, Jeroen Pollet, Michael J. Heffernan, C. Patrick McAtee, David A. Engler, Rise K. Matsunami, Ulrich Strych, Oluwatoyin A. Asojo, Peter J. Hotez, Maria Elena Bottazzi
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2016)
Article
Biotechnology & Applied Microbiology
Meagan A. Barry, Qian Wang, Kathryn M. Jones, Michael J. Heffernan, Munir H. Buhaya, Coreen M. Beaumier, Brian P. Keegan, Bin Zhan, Eric Dumonteil, Maria Elena Bottazzi, Peter J. Hotez
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2016)
Editorial Material
Infectious Diseases
Peter J. Hotez
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Editorial Material
Infectious Diseases
Peter J. Hotez
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Editorial Material
Infectious Diseases
Rebecca Du, Peter J. Hotez, Waleed S. Al-Salem, Alvaro Acosta-Serrano
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Review
Infectious Diseases
Peter J. Hotez, Bernard Pecoul, Suman Rijal, Catharina Boehme, Serap Aksoy, Mwelecele Malecela, Roberto Tapia-Conyer, John C. Reeder
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Review
Pediatrics
Peter J. Hotez
