Loss of Trabid, a New Negative Regulator of the Drosophila Immune-Deficiency Pathway at the Level of TAK1, Reduces Life Span

Pirk Is a Negative Regulator of the Drosophila Imd Pathway

(2014) A. Kleino et al.   JOURNAL OF IMMUNOLOGY

The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the tolerance to gut microbiota

(2013) Widad Dantoft et al.   BMC BIOLOGY

Regulation of NF-κB by ubiquitination

(2013) Jueqi Chen et al.   CURRENT OPINION IN IMMUNOLOGY

big bang gene modulates gut immune tolerance in Drosophila

(2013) F. Bonnay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFα-induced NF-κB activation via mediating TAK1 degradation

(2012) Yihui Fan et al.   CELLULAR SIGNALLING

TAK1 ubiquitination regulates doxorubicin-induced NF-κB activation

(2012) Li Liang et al.   CELLULAR SIGNALLING

The UPD3 cytokine couples environmental challenge and intestinal stem cell division through modulation of JAK/STAT signaling in the stem cell microenvironment

(2012) Feng Zhou et al.   DEVELOPMENTAL BIOLOGY

Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling

(2012) Annika Meinander et al.   EMBO JOURNAL

Regulation of NF-κB by deubiquitinases

(2012) Edward W. Harhaj et al.   IMMUNOLOGICAL REVIEWS

Drosophila as a model system to unravel the layers of innate immunity to infection

(2012) I. Kounatidis et al.   Open Biology

Wild-type Drosophila melanogaster as an alternative model system for investigating the pathogenicity of Candida albicans

(2011) M. T. Glittenberg et al.   Disease Models & Mechanisms

Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection

(2011) Juan C. Paredes et al.   IMMUNITY

Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling

(2011) S. C. Shin et al.   SCIENCE

Expanding role of ubiquitination in NF-κB signaling

(2010) Siqi Liu et al.   CELL RESEARCH

TAK1 Lys-158 but not Lys-209 is required for IL-1β-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-κB activation

(2010) Yihui Fan et al.   CELLULAR SIGNALLING

Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-κB Signaling

(2010) Nicholas Paquette et al.   MOLECULAR CELL

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut

(2009) Huaqi Jiang et al.   CELL

The Drosophila Ubiquitin-Specific Protease dUSP36/Scny Targets IMD to Prevent Constitutive Immune Signaling

(2009) Dominique Thevenon et al.   Cell Host & Microbe

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

(2009) N. Buchon et al.   GENES & DEVELOPMENT

Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation

(2009) Yihui Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the ubiquitin system in cancer therapy

(2009) Daniela Hoeller et al.   NATURE

Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes

(2009) D. Erturk-Hasdemir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

(2009) Lars Vereecke et al.   TRENDS IN IMMUNOLOGY

PIMS Modulates Immune Tolerance by Negatively Regulating Drosophila Innate Immune Signaling

(2008) Nouara Lhocine et al.   Cell Host & Microbe

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

(2008) H. Tran et al.   GENES & DEVELOPMENT

Rudra Interrupts Receptor Signaling Complexes to Negatively Regulate the IMD Pathway

(2008) Kamna Aggarwal et al.   PLoS Pathogens