RPM-1 Uses Both Ubiquitin Ligase and Phosphatase-Based Mechanisms to Regulate DLK-1 during Neuronal Development

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

(2013) Sarah Huntwork-Rodriguez et al.   JOURNAL OF CELL BIOLOGY

Loss of the Spectraplakin Short Stop Activates the DLK Injury Response Pathway in Drosophila

(2013) V. Valakh et al.   JOURNAL OF NEUROSCIENCE

Dscam Expression Levels Determine Presynaptic Arbor Sizes in Drosophila Sensory Neurons

(2013) Jung Hwan Kim et al.   NEURON

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

(2013) T. A. Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction

(2013) Elisabetta Babetto et al.   Cell Reports

Bimodal Control of Dendritic and Axonal Growth by the Dual Leucine Zipper Kinase Pathway

(2013) Xin Wang et al.   PLOS BIOLOGY

N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells

(2012) Toko Chida et al.   BIOCHEMICAL JOURNAL

A Permissive Role of Mushroom Body α/β Core Neurons in Long-Term Memory Consolidation in Drosophila

(2012) Cheng Huang et al.   CURRENT BIOLOGY

RAE-1, a Novel PHR Binding Protein, Is Required for Axon Termination and Synapse Formation in Caenorhabditis elegans

(2012) B. Grill et al.   JOURNAL OF NEUROSCIENCE

Regulation of DLK-1 Kinase Activity by Calcium-Mediated Dissociation from an Inhibitory Isoform

(2012) Dong Yan et al.   NEURON

Dual Leucine Zipper Kinase Is Required for Retrograde Injury Signaling and Axonal Regeneration

(2012) Jung Eun Shin et al.   NEURON

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

(2012) Xin Xiong et al.   PLOS BIOLOGY

PPM-1, a PP2Cα/β phosphatase, Regulates Axon Termination and Synapse Formation inCaenorhabditis elegans

(2011) Erik D. Tulgren et al.   GENETICS

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

(2011) Arundhati Sengupta Ghosh et al.   JOURNAL OF CELL BIOLOGY

Highwire Regulates Guidance of Sister Axons in the Drosophila Mushroom Body

(2011) J. E. Shin et al.   JOURNAL OF NEUROSCIENCE

Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons

(2011) Xiaolin Tian et al.   NATURE NEUROSCIENCE

Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways

(2011) P. Nix et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHRs: bridging axon guidance, outgrowth and synapse development

(2010) Michelle D Po et al.   CURRENT OPINION IN NEUROBIOLOGY

Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis

(2010) Ulla Schwertassek et al.   FEBS Journal

The Ubiquitin Ligase MYCBP2 Regulates Transient Receptor Potential Vanilloid Receptor 1 (TRPV1) Internalization through Inhibition of p38 MAPK Signaling

(2010) Sabrina Holland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury

(2010) Xin Xiong et al.   JOURNAL OF CELL BIOLOGY

Synaptic Activity and Activity-Dependent Competition Regulates Axon Arbor Maturation, Growth Arrest, and Territory in the Retinotectal Projection

(2010) N. B. Fredj et al.   JOURNAL OF NEUROSCIENCE

Calcium and Cyclic AMP Promote Axonal Regeneration in Caenorhabditis elegans and Require DLK-1 Kinase

(2010) A. Ghosh-Roy et al.   JOURNAL OF NEUROSCIENCE

Functional characterization of the PP2C phosphatase CaPtc2p in the human fungal pathogen Candida albicans

(2010) Jinrong Feng et al.   YEAST

Guidance Molecules in Synapse Formation and Plasticity

(2010) K. Shen et al.   Cold Spring Harbor Perspectives in Biology

Axon Growth and Guidance: Receptor Regulation and Signal Transduction

(2009) Michael O'Donnell et al.   Annual Review of Neuroscience

Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice

(2009) Aki Itoh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The DLK-1 Kinase Promotes mRNA Stability and Local Translation in C. elegans Synapses and Axon Regeneration

(2009) Dong Yan et al.   CELL

PHR Regulates Growth Cone Pausing at Intermediate Targets through Microtubule Disassembly

(2009) M. Hendricks et al.   JOURNAL OF NEUROSCIENCE

Fbxo45 Forms a Novel Ubiquitin Ligase Complex and Is Required for Neuronal Development

(2009) T. Saiga et al.   MOLECULAR AND CELLULAR BIOLOGY

Phr1 regulates retinogeniculate targeting independent of activity and ephrin-A signalling

(2009) Susan M. Culican et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

(2009) Bradley R Miller et al.   NATURE NEUROSCIENCE

Role of dual leucine zipper-bearing kinase (DLK/MUK/ZPK) in axonal growth

(2009) Kaoru Eto et al.   NEUROSCIENCE RESEARCH

The Ubiquitin Ligase RPM-1 and the p38 MAPK PMK-3 Regulate AMPA Receptor Trafficking

(2009) Eun Chan Park et al.   PLoS One

Axon Regeneration Requires a Conserved MAP Kinase Pathway

(2009) M. Hammarlund et al.   SCIENCE

Molecular Mechanisms of Presynaptic Differentiation

(2008) Yishi Jin et al.   Annual Review of Cell and Developmental Biology

Pam (Protein associated with Myc) functions as an E3 Ubiquitin ligase and regulates TSC/mTOR signaling

(2008) Sangyeul Han et al.   CELLULAR SIGNALLING

The mixed-lineage kinase DLK undergoes Src-dependent tyrosine phosphorylation and activation in cells exposed to vanadate or platelet-derived growth factor (PDGF)

(2008) Alex Daviau et al.   CELLULAR SIGNALLING

Cellular and molecular determinants targeting theCaenorhabditis elegansPHR protein RPM-1 to perisynaptic regions

(2008) Benjamin Abrams et al.   DEVELOPMENTAL DYNAMICS

The PP2C Alphabet Is a Negative Regulator of Stress-Activated Protein Kinase Signaling in Drosophila

(2008) C. Baril et al.   GENETICS

RPM-1, a Caenorhabditis elegans Protein That Functions in Presynaptic Differentiation, Negatively Regulates Axon Outgrowth by Controlling SAX-3/robo and UNC-5/UNC5 Activity

(2008) H. Li et al.   JOURNAL OF NEUROSCIENCE

Toponomics Analysis of Functional Interactions of the Ubiquitin Ligase PAM (Protein Associated with Myc) during Spinal Nociceptive Processing

(2008) Sandra Pierre et al.   MOLECULAR & CELLULAR PROTEOMICS

UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites

(2008) Vivian Y. Poon et al.   NATURE