SHP2 Regulates Chondrocyte Terminal Differentiation, Growth Plate Architecture and Skeletal Cell Fates

Expression of collagen type I, II, X and Ki-67 in osteochondroma compared to human growth plate cartilage

(2015) K Huch et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice

(2013) P. E. Lapinski et al.   Disease Models & Mechanisms

An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: Applications in mice with bone property alteringLrp5mutations

(2013) Ugur M Ayturk et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Targeted Disruption ofShp2in Chondrocytes Leads to Metachondromatosis With Multiple Cartilaginous Protrusions

(2013) Harry KW Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling

(2013) Wentian Yang et al.   NATURE

Induction of SHP2 Deficiency in Chondrocytes Causes Severe Scoliosis and Kyphosis in Mice

(2013) Harry K. W. Kim et al.   SPINE

Regulation of endochondral ossification by transcription factors

(2012) Riko Nishimura   Frontiers in Bioscience-Landmark

Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes

(2012) L Ho et al.   ONCOGENE

Can MR imaging challenge the commonly accepted theory of the pathogenesis of solitary enchondroma of long bone?

(2012) H. Douis et al.   SKELETAL RADIOLOGY

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

(2011) M Fernanda Amary et al.   JOURNAL OF PATHOLOGY

Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2

(2011) M Fernanda Amary et al.   NATURE GENETICS

Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome

(2011) Twinkal C Pansuriya et al.   NATURE GENETICS

Peripheral chondrosarcoma progression is associated with increased type X collagen and vascularisation

(2011) Carlos E. de Andrea et al.   VIRCHOWS ARCHIV

Loss-of-Function Mutations in PTPN11 Cause Metachondromatosis, but Not Ollier Disease or Maffucci Syndrome

(2011) Margot E. Bowen et al.   PLoS Genetics

From RNA-seq reads to differential expression results

(2011) Alicia Oshlack et al.   GENOME BIOLOGY

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification

(2010) T. Hattori et al.   DEVELOPMENT

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

(2010) T. J. Bauler et al.   Disease Models & Mechanisms

Phosphate-induced Apoptosis of Hypertrophic Chondrocytes Is Associated with a Decrease in Mitochondrial Membrane Potential and Is Dependent upon Erk1/2 Phosphorylation

(2010) Susanne U. Miedlich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal

(2010) Arjun Sebastian et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Fibroblast Expression of an I B Dominant-Negative Transgene Attenuates Renal Fibrosis

(2010) T. Inoue et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Identification of light and dark hypertrophic chondrocytes in mouse and rat chondrocyte pellet cultures

(2010) K.-S. Chen et al.   TISSUE & CELL

Whole-Genome Sequencing of a Single Proband Together with Linkage Analysis Identifies a Mendelian Disease Gene

(2010) Nara L. M. Sobreira et al.   PLoS Genetics

Benign Cartilaginous Tumors of Bone

(2009) Salvatore Romeo et al.   ADVANCES IN ANATOMIC PATHOLOGY

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone

(2009) Rishard Salie et al.   BONE

Multiple osteochondromas: mutation update and description of the multiple osteochondromas mutation database (MOdb)

(2009) Ivy Jennes et al.   HUMAN MUTATION

PGE2 Signaling Through the EP4 Receptor on Fibroblasts Upregulates RANKL and Stimulates Osteolysis

(2009) Ryosuke Tsutsumi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Play Essential Roles in Osteoblast Differentiation and in Supporting Osteoclastogenesis

(2009) T. Matsushita et al.   MOLECULAR AND CELLULAR BIOLOGY

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(2009) Anthony J. Trimboli et al.   NATURE

A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes

(2009) K. B. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Msx2 Stimulates Chondrocyte Maturation by Controlling Ihh Expression

(2008) Katsuhiko Amano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sox9, a key transcription factor of bone morphogenetic protein-2-induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter

(2008) Qiuhui Pan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Primary culture and phenotyping of murine chondrocytes

(2008) Marjolaine Gosset et al.   Nature Protocols