Review
Virology
Fengling Feng, Ziyu Wen, Jiaoshan Chen, Yue Yuan, Congcong Wang, Caijun Sun
Summary: Mucosal vaccines are a promising strategy for superior protection against pathogens, but face challenges such as poor adhesion and uptake. Efforts have been made to overcome these issues, including novel administration routes and the development of mucosa-targeting vectors and adjuvants.
Review
Public, Environmental & Occupational Health
Bayissa Chala, Feyissa Hamde
Summary: Vector-borne emerging and re-emerging diseases pose significant public health challenges globally. Interactions among pathogens, hosts, environment, and social demographic factors are key to the emergence and re-emergence of these diseases. Ongoing evolution of pathogens, population growth, urbanization, and climate change are among the factors linked with the appearance and resurgence of vector-borne infectious diseases.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Public, Environmental & Occupational Health
Seher Topluoglu, Aysegul Taylan-Ozkan, Emine Alp
Summary: Emerging Infectious Diseases (EIDs) and Re-Emerging Infectious Diseases (REIDs) are significant health problems, with up to 75% having zoonotic origin. Factors like destruction of habitats, population migration due to conflicts, and insufficient disease prevention programs contribute to their emergence and distribution. Natural disasters and wars have a major impact on the spread of diseases and worsen health risks.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Alice Italia, Mohammed Monsoor Shaik, Francesco Peri
Summary: This review presents and discusses emerging pharmacological strategies that target major virulence factors of antibiotic-resistant Mycobacterium tuberculosis (Mtb). It is divided into three parts focusing on the cell wall, lipoarabinomannan, and secretory proteins, which play important roles in Mtb pathogenicity. The article provides a comprehensive overview of drugs and drug candidates that target cell walls, envelopes, and secretory systems, and also highlights the molecular understanding of Mtb pathogenesis and potential future directions in therapeutic strategies for combating antibiotic-resistant Mtb infection.
Review
Immunology
Larissa Vuitika, Wasim A. Prates-Syed, Jaqueline Dinis Queiros Silva, Karin P. Crema, Nelson Cortes, Aline Lira, Julia Beatriz Menuci Lima, Niels Olsen Saraiva Camara, Lena F. Schimke, Otavio Cabral-Marques, Mohammad Sadraeian, Lorena C. S. Chaves, Gustavo Cabral-Miranda
Summary: This article discusses the advances in vaccinology and the challenges encountered in the vaccine development pipeline for selected NTDs and emerging and reemerging infectious diseases.
Review
Microbiology
Hasnat Tariq, Sannia Batool, Saaim Asif, Mohammad Ali, Bilal Haider Abbasi
Summary: Virus-like particles (VLPs) are nanostructures with various applications in therapeutics, immunization, and diagnostics. Recent advancements in biomedical engineering have made commercially available VLP-based vaccines widely used in combating infectious diseases. However, there are production and fabrication challenges that need to be addressed before VLP-based approaches can be widely used. This review provides insights into the characteristics, expression systems, and potential applicability of VLP-based vaccines, emphasizing their potential as ideal candidates to combat emerging virulent pathogens and induce immunity against them.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stanislaw Kulczyk, Mariola Koszytkowska-Stawinska
Summary: A new de novo drug design procedure, which integrates de novo and fragment-based drug design methods, is proposed. This uncomplicated method can be used to design new molecules targeting newly discovered or under researched targets, even in the absence of experimental data.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Medicine, General & Internal
Abhilasha Pankaj Boruah, Kiran T. Thakur
Summary: The rapid spread of arboviral infections, which are transmitted by arthropods, has become a global health concern. These infections can cause a wide range of clinical presentations, from asymptomatic infection to severe neurological diseases. The pathogenesis of arboviral infections is still being investigated, but shared neuroanatomical pathways among these viruses may provide insights for future therapeutic targets. It is crucial to consider the potential role of global climate change and human environmental disruption in the shifting infection transmission patterns and distribution of arboviral vectors when assessing patients with encephalitic presentations.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Medicine, General & Internal
Mariam Abdulmonem Mansouri, Frank Kee, Leandro Garcia, Declan T. Bradley
Summary: This article discusses the complexity of emerging infectious diseases (EIDs) and highlights the role of systems science in understanding and controlling EIDs. The research aims to explore the application of systems methods in controlling EIDs, identify knowledge gaps, and disseminate the results.
Review
Virology
Wenshuo Zhou, Linglei Jiang, Shimiao Liao, Feifei Wu, Guohuan Yang, Li Hou, Lan Liu, Xinping Pan, William Jia, Yuntao Zhang
Summary: RNA vaccines, including mRNA, circRNA, and saRNA vaccines, have shown great potential in vaccine development with advantages such as high efficacy, adaptability, and induction of both humoral and cellular immunity. However, challenges including technology immaturity, high research expenses, limited antibody response duration, mRNA stability, low efficiency of circRNA cyclization, and side product production of double-stranded RNA hinder the widespread utilization of RNA vaccines.
Review
Oncology
Miaojin Zhu, Jia Ji, Danrong Shi, Xiangyun Lu, Baohong Wang, Nanping Wu, Jie Wu, Hangping Yao, Lanjuan Li
Summary: Monkeypox, caused by the monkeypox virus, has become a global concern during the ongoing COVID-19 pandemic. The re-emergence of this virus and outbreaks in multiple nonendemic countries require attention and control measures.
FRONTIERS OF MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Min Zhou, Ayseguel Varol, Thomas Efferth
Summary: Malaria is one of the most widespread infectious diseases globally, with increasing drug resistance posing new challenges in treatment. Multi-omics technologies offer a comprehensive view of biological mechanisms, aiding research on malaria progress and resistance mechanisms.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Xiaowei Ma, Jianyun Lu, Weisi Liu
Summary: This study aims to investigate the knowledge of emerging and reemerging infectious diseases among the public in Guangzhou and provide a scientific basis for health information strategies. The results show that the majority of participants have heard of Middle East respiratory syndrome and Zika, while the knowledge of Ebola and plague is relatively low. Education level and income are key factors that influence knowledge rates.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Karanvir Kaushal, Phulan Sarma, S. Rana, Bikash Medhi, Manisha Naithani
Summary: This study aims to elucidate the role of artificial intelligence (AI) in therapeutics for COVID-19. The study found that AI has promising applications in drug repurposing and novel drug discovery, leading to faster identification of potential drugs and vaccine candidates. However, reliance on AI algorithms alone is not advisable at this stage, and evidence-based approaches are needed to confirm their usefulness.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Immunology
Lu Yang, Lin Tang, Ming Zhang, Chaoyong Liu
Summary: Vaccines play a crucial role in preventing infectious diseases, and mRNA vaccines have attracted significant attention due to their rapid development and production advantages. However, challenges such as safety and effective delivery need to be overcome in the development of mRNA vaccines. Further efforts are required to optimize molecular designs, enhance protein expression, and improve structural stability.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Evgeny A. Semchenko, Tsitsi D. Mubaiwa, Christopher J. Day, Kate L. Seib
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Immunology
Evgeny A. Semchenko, Christopher J. Day, Kate L. Seib
Review
Microbiology
Kate L. Seib, Yogitha N. Srikhanta, John M. Atack, Michael P. Jennings
ANNUAL REVIEW OF MICROBIOLOGY, VOL 74, 2020
(2020)
Article
Multidisciplinary Sciences
Aimee Tan, Luke V. Blakeway, Taha, Yuedong Yang, Yaoqi Zhou, John M. Atack, Ian R. Peak, Kate L. Seib
Article
Immunology
Sami L. Gottlieb, Francis Ndowa, Edward W. Hook, Carolyn Deal, Laura Bachmann, Laith Abu-Raddad, Xiang-Sheng Chen, Ann Jerse, Nicola Low, Calman A. MacLennan, Helen Petousis-Harris, Kate L. Seib, Magnus Unemo, Leah Vincent, Birgitte K. Giersing
Article
Microbiology
Freda E-C Jen, Margaret R. Ketterer, Evgeny A. Semchenko, Christopher J. Day, Kate L. Seib, Michael A. Apicella, Michael P. Jennings
Summary: This study reveals that KDO can be incorporated as the terminal glycan on LOS of Neisseria gonorrhoeae by the alpha-2,3-sialyltransferase Lst. The presence of KDO on LOS in vivo and the opsonophagocytic killing of N. gonorrhoeae by the KDO-specific monoclonal antibody 6E4 support further development of KDO-LOS structures as vaccine antigens.
Article
Microbiology
Benjamin J. Evert, Valentin A. Slesarenko, Jilsy M. J. Punnasseril, Taha, Jian Zhan, Yaoqi Zhou, Evgeny A. Semchenko, Kate L. Seib
Summary: Neisseria gonorrhoeae is a growing public health threat due to its increasing incidence and antibiotic resistance. Researchers have designed peptides to target and disrupt the activity of the MtrCDE efflux pump, which is responsible for antibiotic resistance in many strains of N. gonorrhoeae. The peptides were able to increase the susceptibility of N. gonorrhoeae strains to antibiotics in a dose-dependent manner without toxicity to human cells. These peptides may be developed as a dual treatment with existing antibiotics for multidrug-resistant gonococcal infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Ben B. Hui, Thilini N. Padeniya, Nic Rebuli, Richard T. Gray, James G. Wood, Basil Donovan, Qibin Duan, Rebecca Guy, Jane S. Hocking, Monica M. Lahra, David A. Lewis, David M. Whiley, David G. Regan, Kate L. Seib
Summary: This study used a mathematical model to assess the potential impact of a Neisseria gonorrhoeae vaccine among MSM. The results indicate that even a vaccine of modest efficacy can substantially reduce the prevalence of gonorrhea in this population, but its impact may be reduced if it is ineffective at preventing oropharyngeal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Editorial Material
Urology & Nephrology
Evgeny A. Semchenko, Kate L. Seib
Summary: Multidrug-resistant Neisseria gonorrhoeae is a global health issue, and the development of a vaccine is crucial for effective control. The use of outer membrane vesicle vaccines shows promise in preventing N. gonorrhoeae infection.
NATURE REVIEWS UROLOGY
(2022)
Review
Immunology
Yara Ruiz Garcia, Woo-Yun Sohn, Kate L. Seib, Muhamed-Kheir Taha, Julio A. Vazquez, Ana Paula S. de Lemos, Kumaran Vadivelu, Mariagrazia Pizza, Rino Rappuoli, Rafik Bekkat-Berkani
Summary: The 4CMenB vaccine elicits immune responses against non-B meningococcal serogroups and N. gonorrhoeae, with real-world evidence showing risk reductions of 69% for meningococcal serogroup W disease and 40% for gonorrhea after immunization.
Review
Immunology
Alexis Hope Branch, Julie L. Stoudenmire, Kate L. Seib, Cynthia Nau Cornelissen
Summary: Neisseria gonorrhoeae and Neisseria meningitidis, human-specific pathogens, have evolved similar mechanisms to survive and adapt in a metal-restricted host. This review discusses the host's regulation of zinc, manganese, and copper levels, and the pathogenic Neisseria's ability to sense and respond to such changes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Caroline Thng, Evgeny A. Semchenko, Ian Hughes, Maree O'Sullivan, Kate L. Seib
Summary: The MenGO study aims to evaluate the efficacy of the four-component meningococcal serogroup B vaccine, 4CMenB, against gonorrhoea and collect data to increase understanding of immune responses to gonorrhoea.
Article
Microbiology
Evgeny A. Semchenko, Xiaofan Chen, Caroline Thng, Maree O'Sullivan, Kate L. Seib
MICROBIOLOGY AUSTRALIA
(2020)
Article
Microbiology
Luke V. Blakeway, Aimee Tan, Ian R. Peak, John M. Atack, Kate L. Seib
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2020)
Article
Microbiology
Luke Blakeway, Aimee Tan, Ian R. Peak, John M. Atack, Kate L. Seib
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2020)
