Modeling Dynamics of Cell-to-Cell Variability in TRAIL-Induced Apoptosis Explains Fractional Killing and Predicts Reversible Resistance

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Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy

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Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1

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Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes

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Systematic Identification of Signal-Activated Stochastic Gene Regulation

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STL-based Analysis of TRAIL-induced Apoptosis Challenges the Notion of Type I/Type II Cell Line Classification

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Proteasome Inhibition Can Impair Caspase-8 Activation upon Submaximal Stimulation of Apoptotic Tumor Necrosis Factor-related Apoptosis Inducing Ligand (TRAIL) Signaling

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A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

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Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

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Dynamics of protein noise can distinguish between alternate sources of gene-expression variability

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On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

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Transcriptional burst frequency and burst size are equally modulated across the human genome

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Exploring the Contextual Sensitivity of Factors that Determine Cell-to-Cell Variability in Receptor-Mediated Apoptosis

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Heterogeneity reduces sensitivity of cell death for TNF-Stimuli

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Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

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Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis

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TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT

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Mammalian Genes Are Transcribed with Widely Different Bursting Kinetics

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Targeting c-FLIP in cancer

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TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1

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Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

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Single-cell NF-κB dynamics reveal digital activation and analogue information processing

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Dynamics of outer mitochondrial membrane permeabilization during apoptosis

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Listening to the noise: random fluctuations reveal gene network parameters

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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

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Intrinsic noise, dissipation cost, and robustness of cellular networks: The underlying energy landscape of MAPK signal transduction

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Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death

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