A Simulated Intermediate State for Folding and Aggregation Provides Insights into ΔN6 β2-Microglobulin Amyloidogenic Behavior

Protein Homeostasis as a Therapeutic Target for Diseases of Protein Conformation

(2013) Barbara Calamini et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Assessing the Effect of Loop Mutations in the Folding Space of β2-Microglobulin with Molecular Dynamics Simulations

(2013) Sílvia Estácio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Monitoring the Interaction between β2-Microglobulin and the Molecular Chaperone αB-crystallin by NMR and Mass Spectrometry

(2013) Gennaro Esposito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, Folding Dynamics, and Amyloidogenesis of D76N β2-Microglobulin

(2013) P. Patrizia Mangione et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomeric States along the Folding Pathways of β2-Microglobulin: Kinetics, Thermodynamics, and Structure

(2013) E. Rennella et al.   JOURNAL OF MOLECULAR BIOLOGY

Native contacts determine protein folding mechanisms in atomistic simulations

(2013) R. B. Best et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycation-π Interactions Are a Driving Force for Molecular Recognition by an Intrinsically Disordered Oncoprotein Family

(2013) Jianhui Song et al.   PLoS Computational Biology

Cation−π Interaction: Its Role and Relevance in Chemistry, Biology, and Material Science

(2012) A. Subha Mahadevi et al.   CHEMICAL REVIEWS

A recurrent D-strand association interface is observed in β-2 microglobulin oligomers

(2012) Matteo Colombo et al.   FEBS Journal

Robustness of atomistic Gō models in predicting native-like folding intermediates

(2012) S. G. Estácio et al.   JOURNAL OF CHEMICAL PHYSICS

Identification of a Conserved Aggregation-Prone Intermediate State in the Folding Pathways of Spc-SH3 Amyloidogenic Variants

(2012) H. Krobath et al.   JOURNAL OF MOLECULAR BIOLOGY

Native-State Heterogeneity of β2-Microglobulin as Revealed by Kinetic Folding and Real-Time NMR Experiments

(2012) Atsushi Mukaiyama et al.   JOURNAL OF MOLECULAR BIOLOGY

The Molten Globule of β2-Microglobulin Accumulated at pH4 and Its Role in Protein Folding

(2012) Atsushi Mukaiyama et al.   JOURNAL OF MOLECULAR BIOLOGY

Reversibility of Prion Misfolding: Insights from Constant-pH Molecular Dynamics Simulations

(2012) Diogo Vila-Viçosa et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Energetics and Mechanism of the Normal-to-Amyloidogenic Isomerization of β2-Microglobulin: On-the-Fly String Method Calculations

(2012) Spencer T. Stober et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Hereditary Systemic Amyloidosis Due to Asp76Asn Variant β2-Microglobulin

(2012) Sophie Valleix et al.   NEW ENGLAND JOURNAL OF MEDICINE

Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations

(2012) S. Bershtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of chemical heterogeneity on protein self-assembly in water

(2012) S.-H. Chong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation

(2012) Y. Yoshimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is there an en route folding intermediate for cold shock proteins?

(2012) Lei Huang et al.   PROTEIN SCIENCE

Structure of an Intermediate State in Protein Folding and Aggregation

(2012) P. Neudecker et al.   SCIENCE

Aromatic Rings in Chemical and Biological Recognition: Energetics and Structures

(2011) Laura M. Salonen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Coarse-grained models for protein aggregation

(2011) Chun Wu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Definition and testing of the GROMOS force-field versions 54A7 and 54B7

(2011) Nathan Schmid et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Characterization of β2-microglobulin conformational intermediates associated to different fibrillation conditions

(2011) Carlo Santambrogio et al.   JOURNAL OF MASS SPECTROMETRY

Conformational Conversion during Amyloid Formation at Atomic Resolution

(2011) Timo Eichner et al.   MOLECULAR CELL

Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic  2-microglobulin variant

(2011) K. Domanska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular Basis of Distinct Aggregation Pathways of Islet Amyloid Polypeptide

(2010) Lei Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folding and Fibrillogenesis: Clues from β2-Microglobulin

(2010) Enrico Rennella et al.   JOURNAL OF MOLECULAR BIOLOGY

Constant-pH Molecular Dynamics Simulations Reveal a β-Rich Form of the Human Prion Protein

(2010) Sara R. R. Campos et al.   JOURNAL OF PHYSICAL CHEMISTRY B

β2-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages

(2010) Cong Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DE-loop mutations affect β2 microglobulin stability, oligomerization, and the low-pH unfolded form

(2010) Carlo Santambrogio et al.   PROTEIN SCIENCE

β2-microglobulin: from physiology to amyloidosis

(2009) Niels H. H. Heegaard   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Glimpses of the molecular mechanisms of β2 -microglobulin fibril formation in vitro: Aggregation on a complex energy landscape

(2009) Geoffrey W. Platt et al.   FEBS LETTERS

Native-unlike Long-lived Intermediates along the Folding Pathway of the Amyloidogenic Protein β2-Microglobulin Revealed by Real-time Two-dimensional NMR

(2009) Alessandra Corazza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Generic Mechanism of β2-Microglobulin Amyloid Assembly at Neutral pH Involving a Specific Proline Switch

(2009) Timo Eichner et al.   JOURNAL OF MOLECULAR BIOLOGY

Competition between Intramolecular and Intermolecular Interactions in an Amyloid-Forming Protein

(2009) Katy E. Routledge et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Dynamics at Constant pH and Reduction Potential: Application to Cytochromec3

(2009) Miguel Machuqueiro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-Aggregation of a Polyalanine Octamer Promoted by Its C-Terminal Tyrosine and Probed by a Strongly Enhanced Vibrational Circular Dichroism Signal

(2009) Thomas J. Measey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Coupling of Folding and Prolyl Isomerization of β2-Microglobulin Studied by Mutational Analysis

(2008) Michiko Sakata et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

A regulatable switch mediates self-association in an immunoglobulin fold

(2008) Matthew F Calabrese et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Acidic range titration of HEWL using a constant-pH molecular dynamics method

(2008) Miguel Machuqueiro et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Dynamic of β2-Microglobulin Fibril Formation and Reabsorption: The Role of Proteolysis

(2003) Vittorio Bellotti et al.   SEMINARS IN DIALYSIS

The solution structure of human β2-microglobulin reveals the prodromes of its amyloid transition

(2002) Giuliana Verdone et al.   PROTEIN SCIENCE