The Self-Limiting Dynamics of TGF-β Signaling In Silico and In Vitro, with Negative Feedback through PPM1A Upregulation

Ubiquitin removal in the TGF-β pathway

(2012) Kamna Aggarwal et al.   NATURE CELL BIOLOGY

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor

(2012) Long Zhang et al.   NATURE CELL BIOLOGY

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

(2012) Pieter J A Eichhorn et al.   NATURE MEDICINE

Trafficking Coordinate Description of Intracellular Transport Control of Signaling Networks

(2011) Jose M.G. Vilar et al.   BIOPHYSICAL JOURNAL

Quantitative analysis of transient and sustained transforming growth factor-  signaling dynamics

(2011) Z. Zi et al.   Molecular Systems Biology

USP15 is a deubiquitylating enzyme for receptor-activated SMADs

(2011) Masafumi Inui et al.   NATURE CELL BIOLOGY

Distinctive Mechanism for Sustained TGF-  Signaling and Growth Inhibition: MEK1 Activation-Dependent Stabilization of Type II TGF-  Receptors

(2010) G. Chen et al.   MOLECULAR CANCER RESEARCH

Quantitative Modeling and Analysis of the Transforming Growth Factor β Signaling Pathway

(2009) Seung-Wook Chung et al.   BIOPHYSICAL JOURNAL

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

Transforming Growth Factor   Depletion Is the Primary Determinant of Smad Signaling Kinetics

(2009) D. C. Clarke et al.   MOLECULAR AND CELLULAR BIOLOGY

Opposite Effects of Dihydrosphingosine 1-Phosphate and Sphingosine 1-Phosphate on Transforming Growth Factor-β/Smad Signaling Are Mediated through the PTEN/PPM1A-dependent Pathway

(2008) Shizhong Bu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system

(2008) B. Schmierer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA