Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

Bet hedging or not? A guide to proper classification of microbial survival strategies

(2011) Imke G. de Jong et al.   BIOESSAYS

Cellular Decision Making and Biological Noise: From Microbes to Mammals

(2011) Gábor Balázsi et al.   CELL

Synthetic chromosome arms function in yeast and generate phenotypic diversity by design

(2011) Jessica S. Dymond et al.   NATURE

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Non-transcriptional regulatory processes shape transcriptional network dynamics

(2011) J. Christian J. Ray et al.   NATURE REVIEWS MICROBIOLOGY

Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation

(2011) Daniel A. Charlebois et al.   PHYSICAL REVIEW LETTERS

Synthetic Biology: Integrated Gene Circuits

(2011) N. Nandagopal et al.   SCIENCE

Synthetic Biology Moving into the Clinic

(2011) W. C. Ruder et al.   SCIENCE

Nonlinear Fitness Landscape of a Molecular Pathway

(2011) Lilia Perfeito et al.   PLoS Genetics

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Functional roles for noise in genetic circuits

(2010) Avigdor Eldar et al.   NATURE

Tuning and controlling gene expression noise in synthetic gene networks

(2010) Kevin F. Murphy et al.   NUCLEIC ACIDS RESEARCH

Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence

(2010) Eitan Rotem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model

(2010) F. Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

(2010) Y. Taniguchi et al.   SCIENCE

Interdependence of Cell Growth and Gene Expression: Origins and Consequences

(2010) M. Scott et al.   SCIENCE

Minimization of Biosynthetic Costs in Adaptive Gene Expression Responses of Yeast to Environmental Changes

(2010) Ester Vilaprinyo et al.   PLoS Computational Biology

Architecture-Dependent Noise Discriminates Functionally Analogous Differentiation Circuits

(2009) Tolga Çağatay et al.   CELL

Growth Rate-Dependent Global Effects on Gene Expression in Bacteria

(2009) Stefan Klumpp et al.   CELL

Metastable Pluripotent States in NOD-Mouse-Derived ESCs

(2009) Jacob Hanna et al.   Cell Stem Cell

Cell population balance, ensemble and continuum modeling frameworks: Conditional equivalence and hybrid approaches

(2009) Michail Stamatakis   CHEMICAL ENGINEERING SCIENCE

Positive selection for elevated gene expression noise in yeast

(2009) Zhihua Zhang et al.   Molecular Systems Biology

Diversity-based, model-guided construction of synthetic gene networks with predicted functions

(2009) Tom Ellis et al.   NATURE BIOTECHNOLOGY

Next-generation synthetic gene networks

(2009) Timothy K Lu et al.   NATURE BIOTECHNOLOGY

Emergent bistability by a growth-modulating positive feedback circuit

(2009) Cheemeng Tan et al.   Nature Chemical Biology

Fitness and its role in evolutionary genetics

(2009) H. Allen Orr   NATURE REVIEWS GENETICS

Drug interactions and the evolution of antibiotic resistance

(2009) Pamela J. Yeh et al.   NATURE REVIEWS MICROBIOLOGY

The second wave of synthetic biology: from modules to systems

(2009) Priscilla E. M. Purnick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression

(2009) D. Nevozhay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cost of gene expression underlies a fitness trade-off in yeast

(2009) G. I. Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

(2009) Eva Jablonka et al.   QUARTERLY REVIEW OF BIOLOGY

Coding-Sequence Determinants of Gene Expression in Escherichia coli

(2009) G. Kudla et al.   SCIENCE

Regulated Fluctuations in Nanog Expression Mediate Cell Fate Decisions in Embryonic Stem Cells

(2009) Tibor Kalmar et al.   PLOS BIOLOGY

Bacterial Toxin–Antitoxin Systems: More Than Selfish Entities?

(2009) Laurence Van Melderen et al.   PLoS Genetics

Synthetic control of a fitness tradeoff in yeast nitrogen metabolism

(2009) Travis S Bayer et al.   Journal of Biological Engineering

Bistability, Epigenetics, and Bet-Hedging in Bacteria

(2008) Jan-Willem Veening et al.   Annual Review of Microbiology

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Metabolic gene regulation in a dynamically changing environment

(2008) Matthew R. Bennett et al.   NATURE

Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

(2008) Hannah H. Chang et al.   NATURE

Stochastic switching as a survival strategy in fluctuating environments

(2008) Murat Acar et al.   NATURE GENETICS

Single-RNA counting reveals alternative modes of gene expression in yeast

(2008) Daniel Zenklusen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Bimodal and Hysteretic Expression in Mammalian Cells from a Synthetic Gene Circuit

(2008) Tobias May et al.   PLoS One

Using noise to probe and characterize gene circuits

(2008) C. D. Cox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bet-hedging and epigenetic inheritance in bacterial cell development

(2008) J.-W. Veening et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Proteomics of Individual Cancer Cells in Response to a Drug

(2008) A. A. Cohen et al.   SCIENCE