Resolving the Ortholog Conjecture: Orthologs Tend to Be Weakly, but Significantly, More Similar in Function than Paralogs
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Title
Resolving the Ortholog Conjecture: Orthologs Tend to Be Weakly, but Significantly, More Similar in Function than Paralogs
Authors
Keywords
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Journal
PLoS Computational Biology
Volume 8, Issue 5, Pages e1002514
Publisher
Public Library of Science (PLoS)
Online
2012-05-18
DOI
10.1371/journal.pcbi.1002514
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Note: Only part of the references are listed.- On the Use of Gene Ontology Annotations to Assess Functional Similarity among Orthologs and Paralogs: A Short Report
- (2012) Paul D. Thomas et al. PLoS Computational Biology
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- Evidence for short-time divergence and long-time conservation of tissue-specific expression after gene duplication
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- The what, where, how and why of gene ontology--a primer for bioinformaticians
- (2011) L. du Plessis et al. BRIEFINGS IN BIOINFORMATICS
- Ensembl 2012
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- Testing the Ortholog Conjecture with Comparative Functional Genomic Data from Mammals
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- Orthology confers intron position conservation
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- Protein Subcellular Relocalization in the Evolution of Yeast Singleton and Duplicate Genes
- (2009) Wenfeng Qian et al. Genome Biology and Evolution
- Evolutionary constraints on structural similarity in orthologs and paralogs
- (2009) Mark E. Peterson et al. PROTEIN SCIENCE
- Protein function prediction – the power of multiplicity
- (2009) Robert Rentzsch et al. TRENDS IN BIOTECHNOLOGY
- How confident can we be that orthologs are similar, but paralogs differ?
- (2009) Romain A. Studer et al. TRENDS IN GENETICS
- Semantic Similarity in Biomedical Ontologies
- (2009) Catia Pesquita et al. PLoS Computational Biology
- Phylogenetic and Functional Assessment of Orthologs Inference Projects and Methods
- (2009) Adrian M. Altenhoff et al. PLoS Computational Biology
- The Gene Ontology's Reference Genome Project: A Unified Framework for Functional Annotation across Species
- (2009) PLoS Computational Biology
- Algorithm of OMA for large-scale orthology inference
- (2008) Alexander CJ Roth et al. BMC BIOINFORMATICS
- The GOA database in 2009--an integrated Gene Ontology Annotation resource
- (2008) D. Barrell et al. NUCLEIC ACIDS RESEARCH
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