The Mycobacterium tuberculosis Drugome and Its Polypharmacological Implications

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Modular architecture of nucleotide-binding pockets

(2010) Pier Federico Gherardini et al.   NUCLEIC ACIDS RESEARCH

A Multidimensional Strategy to Detect Polypharmacological Targets in the Absence of Structural and Sequence Homology

(2010) Jacob D. Durrant et al.   PLoS Computational Biology

Protein Kinase G Is Required for Intrinsic Antibiotic Resistance in Mycobacteria

(2009) K. A. Wolff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery

(2009) L. Xie et al.   BIOINFORMATICS

Aligning Antimicrobial Drug Discovery with Complex and Redundant Host-Pathogen Interactions

(2009) Sarah L. Lebeis et al.   Cell Host & Microbe

Nothing about protein structure classification makes sense except in the light of evolution

(2009) Ruben E Valas et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The topology of drug–target interaction networks: implicit dependence on drug properties and target families

(2009) Jordi Mestres et al.   Molecular BioSystems

Alignment-Free Prediction of a Drug−Target Complex Network Based on Parameters of Drug Connectivity and Protein Sequence of Receptors

(2009) Dolores Viña et al.   MOLECULAR PHARMACEUTICS

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Protein promiscuity and its implications for biotechnology

(2009) Irene Nobeli et al.   NATURE BIOTECHNOLOGY

Drug interactions and the evolution of antibiotic resistance

(2009) Pamela J. Yeh et al.   NATURE REVIEWS MICROBIOLOGY

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

(2009) J. Richard Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting a bacterial stress response to enhance antibiotic action

(2009) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis

(2009) Sarah L. Kinnings et al.   PLoS Computational Biology

Integrating Statistical Predictions and Experimental Verifications for Enhancing Protein-Chemical Interaction Predictions in Virtual Screening

(2009) Nobuyoshi Nagamine et al.   PLoS Computational Biology

FINDSITELHM: A Threading-Based Approach to Ligand Homology Modeling

(2009) Michal Brylinski et al.   PLoS Computational Biology

Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors

(2009) Li Xie et al.   PLoS Computational Biology

Mycobacterium tuberculosis Universal Stress Protein Rv2623 Regulates Bacillary Growth by ATP-Binding: Requirement for Establishing Chronic Persistent Infection

(2009) Joshua E. Drumm et al.   PLoS Pathogens

Inhibitors of FabI, an Enzyme Drug Target in the Bacterial Fatty Acid Biosynthesis Pathway

(2008) Hao Lu et al.   ACCOUNTS OF CHEMICAL RESEARCH

1.9 Å structure of the signal receiver domain of the putative response regulator NarL fromMycobacterium tuberculosis

(2008) Robert Schnell et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Prediction of drug-target interaction networks from the integration of chemical and genomic spaces

(2008) Y. Yamanishi et al.   BIOINFORMATICS

A Ligand-Based Approach to Mining the Chemogenomic Space of Drugs

(2008) Elisabet Gregori-Puigjane et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Data completeness—the Achilles heel of drug-target networks

(2008) Jordi Mestres et al.   NATURE BIOTECHNOLOGY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Genomic-scale prioritization of drug targets: the TDR Targets database

(2008) Fernán Agüero et al.   NATURE REVIEWS DRUG DISCOVERY

MODBASE, a database of annotated comparative protein structure models and associated resources

(2008) U. Pieper et al.   NUCLEIC ACIDS RESEARCH

Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments

(2008) L. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr

(2008) J. Baysarowich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting QseC Signaling and Virulence for Antibiotic Development

(2008) D. A. Rasko et al.   SCIENCE

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE