Mechano-Transduction: From Molecules to Tissues

Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration

(2014) Danfeng Cai et al.   CELL

News from the caves: update on the structure and function of caveolae

(2014) Elena Shvets et al.   CURRENT OPINION IN CELL BIOLOGY

Cellular and physical mechanisms of branching morphogenesis

(2014) Victor D. Varner et al.   DEVELOPMENT

The minimal cadherin-catenin complex binds to actin filaments under force

(2014) C. D. Buckley et al.   SCIENCE

Toward the Directed Self-Assembly of Engineered Tissues

(2014) Victor D. Varner et al.   Annual Review of Chemical and Biomolecular Engineering

The Yin-Yang of Rigidity Sensing: How Forces and Mechanical Properties Regulate the Cellular Response to Materials

(2013) Ingmar Schoen et al.   Annual Review of Materials Research

Spatial patterning of endothelium modulates cell morphology, adhesiveness and transcriptional signature

(2013) Ngan F. Huang et al.   BIOMATERIALS

Nuclear Positioning

(2013) Gregg G. Gundersen et al.   CELL

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

Nuclear Mechanics and Mechanotransduction in Health and Disease

(2013) Philipp Isermann et al.   CURRENT BIOLOGY

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

(2013) Daniel E. Conway et al.   CURRENT BIOLOGY

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation

(2013) Benjamin T. Goult et al.   JOURNAL OF STRUCTURAL BIOLOGY

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Mechanics of Epithelial Tissue Homeostasis and Morphogenesis

(2013) C. Guillot et al.   SCIENCE

Patterning Methods for Polymers in Cell and Tissue Engineering

(2012) Hong Nam Kim et al.   ANNALS OF BIOMEDICAL ENGINEERING

Sacrificial layer technique for axial force post assay of immature cardiomyocytes

(2012) Rebecca E. Taylor et al.   BIOMEDICAL MICRODEVICES

Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells

(2012) Wei Chen et al.   JOURNAL OF CELL BIOLOGY

Microsystems for biomimetic stimulation of cardiac cells

(2012) Chelsey S. Simmons et al.   LAB ON A CHIP

External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane

(2012) Milos Galic et al.   NATURE CELL BIOLOGY

Anomalous Brownian motion discloses viscoelasticity in the ear's mechanoelectrical-transduction apparatus

(2012) A. S. Kozlov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial organization of the extracellular matrix regulates cell-cell junction positioning

(2012) Q. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin IC generates power over a range of loads via a new tension-sensing mechanism

(2012) M. J. Greenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

(2012) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells

(2012) J.-L. Maitre et al.   SCIENCE

Dynamic force-induced direct dissociation of protein complexes in a nuclear body in living cells

(2012) Yeh-Chuin Poh et al.   Nature Communications

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

A mechanism of mechanotransduction at the cell-cell interface

(2011) Shigenobu Yonemura   BIOESSAYS

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

Mechanotransduction at cadherin-mediated adhesions

(2011) Deborah E Leckband et al.   CURRENT OPINION IN CELL BIOLOGY

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Hierarchical architecture influences calcium dynamics in engineered cardiac muscle

(2011) Terrence Pong et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Dynamics of Salivary Gland Morphogenesis

(2011) J. Harunaga et al.   JOURNAL OF DENTAL RESEARCH

Biology and physics of von Willebrand factor concatamers

(2011) T. A. SPRINGER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Three-Dimensional Traction Force Microscopy: A New Tool for Quantifying Cell-Matrix Interactions

(2011) Christian Franck et al.   PLoS One

Cell-ECM traction force modulates endogenous tension at cell-cell contacts

(2011) V. Maruthamuthu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration

(2011) J. Huynh et al.   Science Translational Medicine

The Bacterial Fimbrial Tip Acts as a Mechanical Force Sensor

(2011) Pavel Aprikian et al.   PLOS BIOLOGY

Biohybrid thin films for measuring contractility in engineered cardiovascular muscle

(2010) Patrick W. Alford et al.   BIOMATERIALS

The mechanics of development: Models and methods for tissue morphogenesis

(2010) Nikolce Gjorevski et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting

(2010) Isolde Le Trong et al.   CELL

Unconventional Processive Mechanics of Non-muscle Myosin IIB

(2010) Melanie F. Norstrom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

Robust Mechanosensing and Tension Generation by Myosin VI

(2010) Peiying Chuan et al.   JOURNAL OF MOLECULAR BIOLOGY

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

4D Traction Force Microscopy Reveals Asymmetric Cortical Forces in MigratingDictyosteliumCells

(2010) H. Delanoë-Ayari et al.   PHYSICAL REVIEW LETTERS

Full distance-resolved folding energy landscape of one single protein molecule

(2010) J. C. M. Gebhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Branch formation during organ development

(2010) Nikolce Gjorevski et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Transient Opening of Fibronectin Type III (FNIII) Domains: The Interaction of the Third FNIII Domain of FN with Anastellin

(2009) Tomoo Ohashi et al.   BIOCHEMISTRY

The Role of FilGAP-Filamin A Interactions in Mechanoprotection

(2009) Yulia Shifrin et al.   MOLECULAR BIOLOGY OF THE CELL

Transmission of allostery through the lectin domain in selectin-mediated cell adhesion

(2009) T. T. Waldron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for selectin mechanochemistry

(2009) T. A. Springer   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying cellular traction forces in three dimensions

(2009) Stacey A. Maskarinec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites

(2009) E. Klotzsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis

(2009) H. P. Makarenkova et al.   Science Signaling

Biophysics of Catch Bonds

(2008) Wendy E. Thomas et al.   Annual Review of Biophysics

Integrin connections to the cytoskeleton through talin and vinculin

(2008) Wolfgang H. Ziegler et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin αIIbβ3

(2008) Timothy A. Springer et al.   JOURNAL OF CELL BIOLOGY

Mechanotransduction - a field pulling together?

(2008) C. S. Chen   JOURNAL OF CELL SCIENCE

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microsystems for Biomechanical Measurements

(2008) James J Norman et al.   PEDIATRIC RESEARCH

Myosin I Can Act As a Molecular Force Sensor

(2008) J. M. Laakso et al.   SCIENCE