Article
Biology
Xiaoxue Yuan, Hongping Lu, Yu Zhang, Ming Han, Kai Han, Pu Liang, Shunai Liu, Jun Cheng
Summary: HCBP6 is an important enhancer that activates brown fat to produce heat. It increases the activity of brown fat by upregulating UCP1 expression and increasing the number of mitochondria. In addition, the loss of HCBP6 leads to metabolic pathway disorder and reduction in brown adipocyte development genes.
JOURNAL OF THERMAL BIOLOGY
(2022)
Review
Nutrition & Dietetics
Lloyd Noriega, Cheng-Ying Yang, Chih-Hao Wang
Summary: Brown and beige adipocytes have the ability to generate heat and can be activated by various methods. Understanding the molecular mechanisms of their differentiation and function is crucial for developing clinical therapies. Drugs and nutritional interventions can activate these adipocytes while minimizing potential side effects.
Article
Multidisciplinary Sciences
Jong Han Lee, Ligen Lin, Xiangcang Ye, Christian Wolfrum, Yingjie Chen, Shaodong Guo, Yuxiang Sun
Summary: The study reveals that GHS-R has a cell-autonomous effect in brown adipocytes and regulates BAT thermogenic activity in a temperature- and metabolic state-dependent manner. The thermogenic effect of GHS-R in BAT is more pronounced in a cold environment and differentially variable based on metabolic state. Overall, GHS-R in BAT acts as a metabolic thermostat that differentially regulates thermogenesis in response to different metabolic and thermal stimuli.
Editorial Material
Endocrinology & Metabolism
Imke L. Lemmer, Alexander Bartelt
Summary: An elegant quantitative analysis of brown fat and skeletal muscle metabolite flux reveals that brown fat predominantly uses glucose and lactate and acts as a nitrogen scavenger during thermogenesis.
Article
Multidisciplinary Sciences
Rebecca Oelkrug, Lisbeth Harder, Mehdi Pedaran, Anne Hoffmann, Beke Kolms, Julica Inderhees, Sogol Gachkar, Julia Resch, Kornelia Johann, Olaf Joehren, Kerstin Krause, Jens Mittag
Summary: Maternal hyperthyroidism during pregnancy can program the offspring's glucose sensitivity and response to cold via activation of maternal thyroid hormone receptor beta in a sex-dependent manner.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Felicitas Lopez-Vicchi, Catalina De Winne, Ana Maria Ornstein, Eleonora Sorianello, Judith Toneatto, Damasia Becu-Villalobos
Summary: High serum prolactin levels have detrimental effects on brown adipose tissue, reducing thermogenic markers and causing tissue whitening. Additionally, it alters lipogenic markers in subcutaneous white adipose tissue and exacerbates glucose intolerance and Cidea decrease induced by high fat diets.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Chad C. Doucette, Davide Barteselli, Daniel C. Nguyen, Sophia Blanchard, Mason Pelletier, Devesh Kesharwani, Ed Jachimowicz, Su Su, Michele Karolak, Aaron C. Brown
Summary: In this study, an optogenetic approach was used to activate UCP1-dependent thermogenesis in brown adipocytes. This system allows for precise, chemical free, temporal control of UCP1-dependent thermogenesis, which can contribute to our understanding of brown adipocyte biology and the development of therapies for obesity-related disorders.
Article
Endocrinology & Metabolism
Alana Deutsch, Kosaku Shinoda
Summary: Studies have shown that prolonged exposure to cold can increase the thermogenic capacity of brown adipose tissue through the recruitment of new brown adipocytes. Shamsi et al. and Angueira et al. have identified novel cellular origins of cold-induced brown adipocytes and elucidated the molecular mechanism regulating the expansion of brown adipose tissue.
Article
Biochemistry & Molecular Biology
Tingting Jiang, Duo Su, Xin Liu, Yan Wang, Linjie Wang
Summary: This study found that FGF11 is enriched in brown adipose tissue of goats and promotes differentiation and thermogenesis in brown adipocytes by promoting UCP1 gene expression through EBF2 binding to the UCP1 promoter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Shanshan Chen, Minglu Xu, Min Zhou, Yingxin He, Yongchun Li, Hui Lang, Xuliang Wei, Lijie Yan, Hongde Xu
Summary: The study found that Hibiscus manihot may reduce obesity in mice by changing the composition of the gut microbiota and activating UCP1 to increase thermogenesis of brown fat, making it a potential drug for treating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Medicinal
Lucia Recinella, Barbara De Filippis, Maria Loreta Libero, Alessandra Ammazzalorso, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Letizia Giampietro, Serena Veschi, Alessandro Cama, Federica Mannino, Irene Gasparo, Alessandra Bitto, Rosa Amoroso, Luigi Brunetti, Sheila Leone
Summary: The effects of four new PPAR ligands on inflammation and oxidative stress were investigated, and one of them showed potential as a valuable pharmacological tool.
Article
Endocrinology & Metabolism
Frederike Sass, Christian Schlein, Michelle Y. Jaeckstein, Paul Pertzborn, Michaela Schweizer, Thorsten Schinke, Andrea Ballabio, Ludger Scheja, Joerg Heeren, Alexander W. Fischer
Summary: TFEB is identified as a driver of BAT whitening, mediating mitochondrial degradation through the autophagosomal and lysosomal machinery. This study demonstrates that interfering with the mitochondrial degradation machinery can increase mitochondrial mass in classical BAT under human-relevant conditions, but interfering with autophagy may result in accumulation of nonfunctional mitochondria.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Josef Oeckl, Petra Janovska, Katerina Adamcova, Kristina Bardova, Sarah Brunner, Sebastian Dieckmann, Josef Ecker, Tobias Fromme, Jiri Funda, Thomas Gantert, Piero Giansanti, Maria Soledad Hidrobo, Ondrej Kuda, Bernhard Kuster, Yongguo Li, Radek Pohl, Sabine Schmitt, Sabine Schweizer, Hans Zischka, Petr Zouhar, Jan Kopecky, Martin Klingenspor
Summary: We explore different potential sources of UCP1-independent thermogenesis and identify a futile ATP-consuming triglyceride/fatty acid cycle as the main contributor to cellular heat production in brown adipocytes lacking UCP1. We uncover the mechanism on a molecular level and pinpoint the key enzymes involved using pharmacological and genetic interference.
MOLECULAR METABOLISM
(2022)
Article
Geriatrics & Gerontology
Shinsuke Nirengi, Kristin Stanford
Summary: Aging is a significant risk factor for type 2 diabetes and cardiovascular disease, while regular physical activity can help delay, prevent, or manage the onset and development of various chronic diseases in older adults. Brown adipose tissue (BAT) is thermogenic and protects against age-related diseases, but its activity decreases with age. This review discusses how aging impairs BAT function by inducing whitening and altering signaling pathways, gene expression, and mitochondrial function, as well as potential mechanisms for exercise to counteract these effects.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Avi Lerner, Drashti Kewada, Ayan Ahmed, Kate Hardy, Mark Christian, Stephen Franks
Summary: Polycystic ovary syndrome (PCOS) is associated with reduced postprandial thermogenesis and abnormalities in adipose tissue function, with excess androgen inhibiting brown adipogenesis, attenuating thermogenic activation, and reducing mitochondrial respiration in brown adipose tissue (BAT). These findings may contribute to the reduced postprandial thermogenesis and increased tendency to obesity observed in women with PCOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Alexander W. Fischer, Barbara Cannon, Jan Nedergaard
Article
Medicine, General & Internal
S. Cederstrom, P. Lundman, L. Folkersen, G. Paulsson-Berne, G. Karadimou, P. Eriksson, K. Caidahl, A. Gabrielsen, T. Jernberg, J. Persson, P. Tornvall
JOURNAL OF INTERNAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Marie S. Isidor, Sally Winther, Lasse K. Markussen, Astrid L. Basse, Bjorn Quistorff, Jan Nedergaard, Brice Emanuelli, Jacob B. Hansen
Article
Physiology
Barbara Cannon, Jasper M. A. de Jong, Alexander W. Fischer, Jan Nedergaard, Natasa Petrovic
EXPERIMENTAL PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Larissa Peck, Kennedy Borle, Lasse Folkersen, Jehannine Austin
Summary: The study found that the majority of individuals undergo genetic testing out of curiosity, but only a small number correctly understood and interpreted polygenic risk scores. Over half of the participants experienced negative psychological reactions after receiving their results.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Medicine, General & Internal
John Tengbom, Sofia Cederstrom, Dinos Verouhis, Felix Bohm, Per Eriksson, Lasse Folkersen, Anders Gabrielsen, Tomas Jernberg, Pia Lundman, Jonas Persson, Nawzad Saleh, Magnus Settergren, Peder Sorensson, Yahor Tratsiakovich, Per Tornvall, Christian Jung, John Pernow
Summary: The study found that the gene and protein expression of arginase 1 was significantly elevated in patients with STEMI, indicating a role of arginase 1 in the development of STEMI.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jiangming Sun, Yunpeng Wang, Lasse Folkersen, Yan Borne, Inge Amlien, Alfonso Buil, Marju Orho-Melander, Anders D. Borglum, David M. Hougaard, Olle Melander, Gunnar Engstrom, Thomas Werge, Kasper Lage, Luca Andrea Lotta, Marcus Jones, Aris Baras
Summary: The study introduces a machine learning method, Mondrian Cross-Conformal Prediction (MCCP), that can report disease status conditional probability value at the individual level, providing a potential for personalized genetic risk predictions.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Oliver Pain, Alexandra C. Gillett, Jehannine C. Austin, Lasse Folkersen, Cathryn M. Lewis
Summary: There is a growing interest in the clinical use of polygenic scores, and this study presents a method for converting polygenic scores to the absolute scale for binary and normally distributed phenotypes. The method uses summary statistics and has been validated using data from the UK Biobank sample. This study provides a useful tool for accurately interpreting polygenic scores using only summary statistics.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Miguel Carracedo, Sven-Christian Pawelzik, Gonzalo Artiach, Marianne G. Pouwer, Oscar Plunde, Peter Saliba-Gustafsson, Ewa Ehrenborg, Per Eriksson, Elsbet Pieterman, Leif Stenke, Hans M. G. Princen, Anders Franco-Cereceda, Magnus Back
Summary: This study found that nilotinib can promote aortic valve thickening and valvular interstitial cell calcification, while imatinib does not have this effect. The study also found differential tyrosine kinase expression between healthy and calcified valve tissue. These findings may have important implications for cardiovascular surveillance and personalized medicine in chronic myeloid leukaemia patients.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kiara Lowes, Kennedy Borle, Lasse Folkersen, Jehannine Austin
Summary: The number of people accessing their own polygenic risk scores (PRSs) online is increasing rapidly. However, little is known about the motivations behind this behavior, the emotional reactions to the information, and the subsequent actions taken. Through qualitative interviews with users of Impute.me, researchers found that dissatisfaction with healthcare was a key motivator for seeking PRS information. Participants described being dismissed by healthcare providers and having medical distrust, leading them to advocate for their own health and seek PRSs. These scores were often empowering, but could also cause distress if they didn't align with participants' expectations or family histories. Behavioral changes made in response to PRS results included dietary modifications, changes in supplementation, and talk-based therapy.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Surgery
A. Frisell, O. Bergman, A. Khan, A. Gistera, R. M. Fisher, J. Lagergren, J. de Boniface, M. Halle
Summary: We conducted a comparative study of gene expression patterns in capsular tissue from breast cancer patients who had received radiation therapy after implant-based immediate breast reconstruction. The results revealed that there were inflammatory responses in capsular biopsies regardless of radiotherapy, but radiation specifically increased B-cell-associated inflammatory responses.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Review
Biology
Jan Nedergaard, Gabriella von Essen, Barbara Cannon
Summary: This article discusses whether a decrease in UCP1 activity could cause obesity in humans. Studies in mice suggest that the absence of UCP1 leads to obesity. It is still unknown if similar mechanisms exist in humans.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Gabriella von Essen, Erik Lindsund, Elaina M. Maldonado, Petr Zouhar, Barbara Cannon, Jan Nedergaard
Summary: This study examines the possibility of countering obesity by activating brown or beige adipose tissue and UCP1. The findings show that although UCP1 protein may increase, it is not necessarily utilized for diet-induced thermogenesis. Constant activation of UCP1 is required to effectively ameliorate obesity development.
MOLECULAR METABOLISM
(2023)
Article
Cell Biology
Edyta Biskup, Brian Daniel Larsen, Leonor Rib, Lasse Folkersen, Omid Niazi, Maria R. Kamstrup, Claus Storgaard Sorensen
Article
Endocrinology & Metabolism
Lasse Folkersen, Stefan Gustafsson, Qin Wang, Daniel Hvidberg Hansen, Asa K. Hedman, Andrew Schork, Karen Page, Daria V. Zhernakova, Yang Wu, James Peters, Niclas Eriksson, Sarah E. Bergen, Thibaud S. Boutin, Andrew D. Bretherick, Stefan Enroth, Anette Kalnapenkis, Jesper R. Gadin, Bianca E. Suur, Yan Chen, Ljubica Matic, Jeremy D. Gale, Julie Lee, Weidong Zhang, Amira Quazi, Mika Ala-Korpela, Seung Hoan Choi, Annique Claringbould, John Danesh, George Davey Smith, Federico de Masi, Solve Elmstahl, Gunnar Engstrom, Eric Fauman, Celine Fernandez, Lude Franke, Paul W. Franks, Vilmantas Giedraitis, Chris Haley, Anders Hamsten, Andres Ingason, Asa Johansson, Peter K. Joshi, Lars Lind, Cecilia M. Lindgren, Steven Lubitz, Tom Palmer, Erin Macdonald-Dunlop, Martin Magnusson, Olle Melander, Karl Michaelsson, Andrew P. Morris, Reedik Magi, Michael W. Nagle, Peter M. Nilsson, Jan Nilsson, Marju Orho-Melander, Ozren Polasek, Bram Prins, Erik Palsson, Ting Qi, Marketa Sjogren, Johan Sundstrom, Praveen Surendran, Urmo Vosa, Thomas Werge, Rasmus Wernersson, Harm-Jan Westra, Jian Yang, Alexandra Zhernakova, Johan Arnlov, Jingyuan Fu, J. Gustav Smith, Tonu Esko, Caroline Hayward, Ulf Gyllensten, Mikael Landen, Agneta Siegbahn, James F. Wilson, Lars Wallentin, Adam S. Butterworth, Michael V. Holmes, Erik Ingelsson, Anders Malarstig