Review
Plant Sciences
Sun Hee Hyun, Kiran D. Bhilare, Gyo In, Chae-Kyu Park, Jong-Hoon Kim
Summary: Asian ginseng or Korean ginseng, Panax ginseng, has been traditionally used in Korea and China for the treatment of various diseases. Its main active component, ginsenoside, is known for its pharmacological effects such as antioxidant, anti-inflammatory, and anti-diabetic properties, which can prevent cardiovascular diseases and oxidative stress-related damage.
JOURNAL OF GINSENG RESEARCH
(2022)
Review
Physiology
Marta Martinez-Casales, Raquel Hernanz, Maria J. Alonso
Summary: Hypertension is considered an inflammatory disease with elevated cytokine levels and oxidative stress. In hypertension, the polarization of macrophages to the M1 phenotype plays a key role in producing inflammatory cytokines and oxidative stress.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Teresa Bayo Jimenez, Katie Frenis, Swenja Kroller-Schon, Marin Kuntic, Paul Stamm, Miroslava Kvandova, Matthias Oelze, Huige Li, Sebastian Steven, Thomas Munzel, Andreas Daiber
Summary: This study investigated the protective effects of HO-1 inducer and NRF2 activator on mice exposed to aircraft noise, showing that these treatments can mitigate the adverse effects of noise on vascular function by normalizing arterial hypertension and vascular dysfunction, as well as reducing oxidative stress and inflammation levels triggered by noise exposure. The study identifies new potential targets for mitigating the health effects of environmental noise exposure, suggesting that natural dietary constituents with HO-1 and NRF2 induction properties could be promising for preventive measures.
Article
Biochemistry & Molecular Biology
Valeria Sorrenti, Agata Grazia D'Amico, Ignazio Barbagallo, Valeria Consoli, Salvo Grosso, Luca Vanella
Summary: The overexpression of HO-1 in NSCLC cells and the inhibitory effect of SnMP on cell proliferation and migration, as well as the increase in oxidative stress, suggest that HO activity inhibition may be a potential target for selective chemotherapy in lung cancer subtypes.
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Plant Sciences
Xiaojuan Peng, Mingqian Hao, Yingchun Zhao, Yuan Cai, Xueyan Chen, Huiying Chen, Yue Zhang, Ling Dong, Xinglong Liu, Chuanbo Ding, Wencong Liu, Min Yang, Yunqing Luo
Summary: The study found that red ginseng (RG) is more effective in delaying D-Gal-induced aging process compared to Panax ginseng (PG), possibly due to the presence of higher levels of total polyphenols, rare ginsenosides, and non-starch polysaccharides in RG.
Article
Immunology
Mirrin J. Dorresteijn, Douwe Dekker, Jelle Zwaag, Suzanne Heemskerk, Hennie M. J. Roelofs, Paul Smits, Johannes G. van der Hoeven, Frank A. D. T. G. Wagener, Peter Pickkers
Summary: Inflammation-induced free radical release is important in the pathogenesis of several diseases. This study investigated the impact of atazanavir-induced hyperbilirubinemia on antioxidant capacity, inflammation, and vascular dysfunction in human experimental endotoxemia. The results showed that hyperbilirubinemia increased antioxidant capacity, attenuated interleukin-10 release, and prevented vascular hyporesponsiveness during systemic inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Article
Psychiatry
Thomas Bertrand, Ayda Tavitian, Julia M. Galindez, Vimal Kothari, Shrisha Mohit, Carmela Galindez, Adrienne Liberman, Judy Glass, Ana M. Velly, Mervyn Gornitsky, Karl Looper, Soham Rej, Hyman M. Schipper
Summary: This study found that higher levels of salivary HO-1 expression were detected in patients experiencing an acute psychotic episode compared to control participants, and this overexpression was positively associated with psychiatric symptom severity and disability. The results suggest that overexpression of HO-1 in saliva may serve as a potential biomarker for psychosis and should be explored further in larger clinical trials.
PSYCHIATRY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Lihe Lu, Yining Li, Qian Dong, Jiansong Fang, An Chen, Zirong Lan, Yuanzhi Ye, Jianyun Yan, Qingchun Liang
Summary: This study combined systems pharmacology-based strategy and experiments to identify the therapeutic potential of Wogonin for vascular calcification via upregulating heme oxygenase-1 (HMOX-1) and reducing oxidative stress.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Yunlong Li, Kuai Ma, Zhongyu Han, Mingxuan Chi, Xiyalatu Sai, Ping Zhu, Zhaolun Ding, Linjiang Song, Chi Liu
Summary: The increasing incidence of kidney diseases poses a significant burden on the healthcare system, with complex pathophysiological processes involved. Heme oxygenase-1 (HO-1) has gained attention for its cytoprotective properties and role in regulating oxidative stress. Strategies targeting HO-1 have shown promise in animal models, suggesting its potential as a therapeutic target for kidney diseases.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Eun-Nam Kim, Oryon Kaygusuz, Hyun-Su Lee, Gil-Saeng Jeong
Summary: The study quantitatively analyzed the contents of ginsenosides isolated from Panax ginseng fruit extract and evaluated their anti-inflammatory effects in human periodontal ligament cells. The major ginsenosides Re, Ra8, and Rf in ginseng fruit showed potential in inhibiting periodontitis and alveolar bone loss through various pathways, providing important data for future studies and suggesting them as potential treatment options for the condition.
Review
Biochemistry & Molecular Biology
Jia-Jing Lu, Ayitila Abudukeyoumu, Xing Zhang, Li-Bing Liu, Ming-Qing Li, Feng Xie
Summary: This review summarizes the different effects of HO-1 under normal and diseased conditions, with implications on the diagnosis and treatment of gynecological cancers, suggesting its potential role in cell proliferation, metastasis, immune regulation, and angiogenesis as an oncogene.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Liping Zou, Guiping Cheng, Chengcheng Xu, Heyu Liu, Yingying Wang, Nianyu Li, Xiaorong Fan, Changhong Zhu, Wei Xia
Summary: CuNPs induce oxidative stress in human ovarian granulosa cells, possibly through the MAPK14-Nrf2 signaling pathway to induce HO-1 expression, but HO-1 can protect cells from oxidative stress induced by CuNPs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Akihiro Yachie
Summary: HO-1 is crucial in protecting tissues and organs from oxidative stress and excessive inflammatory reactions. Deficiency in HO-1 leads to dysfunction in monocytes, macrophages, and endothelial cells, resulting in systemic inflammatory response syndrome. Therapeutic induction of HO-1 production through pharmacological intervention shows promise in controlling inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Seung Eun Lee, Hye Rim Park, Hyemi Kim, Yeoum Choi, Young-Ho Jin, Cheung-Seog Park, Hyun-Jong Ahn, Jeong-Je Cho, Yong Seek Park
MOLECULAR & CELLULAR TOXICOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Seung Eun Lee, Hye Rim Park, Hong Duck Yun, Hyemi Kim, Young-Ho Jin, Cheung-Seog Park, Hyun-Jong Ahn, Jeong-Je Cho, Yong Seek Park
MOLECULAR & CELLULAR TOXICOLOGY
(2017)
Review
Biochemistry & Molecular Biology
Seung Eun Lee, Yong Seek Park
MOLECULAR & CELLULAR TOXICOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Hye Rim Park, Seung Eun Lee, Gun Woo Son, Hong Duck Yun, Cheung-Seog Park, Hyun-Jong Ahn, Jeong-Je Cho, Jongsung Lee, Yong Seek Park
MOLECULAR & CELLULAR TOXICOLOGY
(2017)
Article
Biochemical Research Methods
Hye Rim Park, Seung Eun Lee, Hyemi Kim, Jongsung Lee, Yong Seek Park
Article
Dermatology
Y. Kim, J. Y. Cho, S. W. Oh, M. Kang, S. E. Lee, E. Jung, Y. S. Park, J. Lee
BRITISH JOURNAL OF DERMATOLOGY
(2018)
Article
Pharmacology & Pharmacy
Goeun Lee, Eunhee Yang, Sojin Kim, Cheung-Seog Park, Yong Seek Park, Young-Ho Jin
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2018)
Article
Biochemistry & Molecular Biology
Hye Rim Park, Seung Eun Lee, Hyemi Kim, Seeun Jeon, Dongkyo Han, Young-Ho Jin, Jeong-Je Cho, Hyun-Jong Ahn, Cheung-Seog Park, Jongsung Lee, Yong Seek Park
MOLECULAR & CELLULAR TOXICOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Seung Eun Lee, Hye Rim Park, Cheung-Seog Park, Hyun-Jong Ahn, Jeong-Je Cho, Jongsung Lee, Yong Seek Park
Article
Chemistry, Applied
Yong Kwan Noh, Avelino Dos Santos Da Costa, Yong Seek Park, Ping Du, Ik-Hwan Kim, Kwideok Park
CARBOHYDRATE POLYMERS
(2019)
Review
Biology
Seung Eun Lee, Yong Seek Park
Summary: Vascular diseases, such as diabetes, atherosclerosis, and COPD, are major causes of death globally. Research into the effects of dietary phytochemicals on antioxidant enzymes in vascular diseases has shown promising outcomes in preventing pathologies associated with vascular diseases.
Article
Biochemistry & Molecular Biology
Hye Rim Park, Seung Eun Lee, Yoojung Yi, Sangji Moon, Hyunkyung Yoon, Chae Won Kang, Jaetaek Kim, Yong Seek Park
Summary: The study confirmed the impact of KRG on the expression of miRNAs and mRNAs in renal cells of diabetic mice, with 46 miRNAs and 827 mRNAs showing altered expression levels. Furthermore, it was found that mRNA expression was inversely correlated with miRNA expression, and their biological processes and signaling pathways were validated through GO analysis.
MOLECULAR & CELLULAR TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Seung Eun Lee, Yoojung Yi, Sangji Moon, Hyunkyung Yoon, Yong Seek Park
Summary: Mitochondria, dynamic organelles, play crucial roles in respiration, energy production, metabolism, and cell fate decisions. Damage and dysfunction of mitochondria can lead to the development of various diseases such as cancer, diabetes, and neurodegenerative and cardiovascular disorders. The association between mitochondrial damage caused by environmental contaminants, including micro- and nanoplastics, and disease pathogenesis has been reported. This review discusses the impact of micro- and nanoplastics on mitochondria and provides an overview of current research in this field.
Article
Biochemistry & Molecular Biology
Eunjeong Kang, Yufei Li, Bora Kim, Ki Young Huh, Miyeun Han, Jung-Hyuck Ahn, Hye Youn Sung, Yong Seek Park, Seung Eun Lee, Sangjun Lee, Sue K. Park, Joo-Youn Cho, Kook-Hwan Oh
Summary: In this study, metabolomics was used to discover novel biomarkers for predicting the risk of deterioration in patients with different causes of chronic kidney disease (CKD). The models constructed with selected metabolites and clinical parameters showed better ability to predict CKD progression compared to clinical parameters only.
Article
Nutrition & Dietetics
Sanggon Lee, Hyun-Jong Ahn, Yong Seek Park, Ji-Hyun Kim, Yoon-Seong Kim, Jeong-Je Cho, Cheung-Seog Park
Summary: The study found that NXP081 has anti-inflammatory effects on AD and can improve its symptoms, indicating its potential therapeutic value.
