Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Mohadeseh Fathi, Tianyue Zhai, Mohammad Taheri, Peixin Dong
Summary: Pancreatic cancer is a deadly neoplasm with poor prognosis, and recent research has highlighted the impact of lncRNAs on its progression. Some lncRNAs are oncogenic while others act as tumor suppressors in pancreatic cancer. Dysregulated expression of specific lncRNAs may serve as prognostic markers in patients with this aggressive cancer.
Review
Medicine, Research & Experimental
Bowen Huang, Haoran Huang, Shuting Zhang, Dingyue Zhang, Qingya Shi, Jianzhou Liu, Junchao Guo
Summary: Pancreatic cancer is a deadly disease, and early diagnosis and treatment are crucial. Artificial intelligence technology can be used for early screening, predicting prognosis, and developing diagnostic systems for pancreatic cancer. It also has wide applications in health records and imaging parameters estimation.
Review
Medicine, General & Internal
Qunli Xiong, Zhiwei Zhang, Yongfeng Xu, Qing Zhu
Summary: This review provides an overview of the histogenesis, genetic features, diagnosis, treatment, and prognosis of pancreatic adenosquamous carcinoma (PASC), a rare pathological subtype of pancreatic cancer, as well as pancreatic squamous cell carcinoma (PSCC). The information presented here clarifies our understanding of PASC and offers useful avenues for further research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jihao Tu, Zhehao Huang, Yin Wang, Meijing Wang, Zukun Yin, Xianglin Mei, Meiying Li, Lisha Li
Summary: This study analyzed transcriptome data and constructed co-expression networks to reveal gradually activated gene networks during the progression of pancreatic diseases. The number of differentially expressed genes increases as the pancreatic disease worsens, with upregulation of gene networks involving T cells and interferon.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Shi Dong, Wancheng Li, Xin Li, Zhengfeng Wang, Zhou Chen, Huaqing Shi, Ru He, Chen Chen, Wence Zhou
Summary: Metabolic reprogramming and the relationship between glucose metabolism and tumor microenvironment play a crucial role in pancreatic cancer. This study sheds light on the development of new therapies targeting the metabolism of cancer cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
David Digomann, Johannes Strack, Max Heiduk, Ioana Plesca, Luise Rupp, Charlotte Reiche, Simone Nicolaus, Carolin Beer, Ulrich Sommer, Marc Schmitz, Marius Distler, Juergen Weitz, Adrian M. Seifert, Lena Seifert
Summary: This study found that increased expression of VISTA in pancreatic tumor cells is associated with decreased overall survival. Immune cells also express VISTA, and interaction with tumor cells further enhances their VISTA expression. Recombinant VISTA inhibits proinflammatory T-cell function and cytokine production. VISTA blockade results in decreased tumor weights in an orthotopic PDAC mouse model.
Article
Oncology
Mira Lanki, Hanna Seppanen, Harri Mustonen, Aino Salmiheimo, Ulf-Hakan Stenman, Marko Salmi, Sirpa Jalkanen, Caj Haglund
Summary: In this study, hs-CRP and seven cytokines were identified as potential prognostic factors for survival prediction in pancreatic ductal adenocarcinoma patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Yuji Shimizu, Teiichi Sugiura, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Katsuhiko Uesaka
Summary: The study suggests that DUPAN-2 may serve as a complementary biomarker to CA19-9 in pancreatic cancer. The combination of these two markers can help predict the prognosis of patients before surgery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Jinfeng Zhu, Hong Teng, Xiaojian Zhu, Jingxuan Yuan, Qiong Zhang, Yeqing Zou
Summary: KLF3, a key transcriptional repressor, plays significant roles in various biological functions and is particularly important in pancreatic cancer. Abnormal expression of KLF3 is found in multiple tumors and silencing KLF3 expression inhibits pancreatic cancer progression. It is involved in immune-related pathways and tumor progression-related pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Jieqiong Wang, Yajie Chen, Canhua Huang, Qian Hao, Shelya X. Zeng, Sara Omari, Yu Zhang, Xiang Zhou, Hua Lu
Summary: Valosin-containing protein (VCP) has been identified as a novel regulator of p53-R273H stability, stabilizing p53-R273H through binding to MDM2 and disrupting its association with mutant p53, while inhibition of VCP leads to ubiquitination and degradation of p53-R273H, promoting cell death. VCP may serve as a potential target for the development of pancreatic cancer therapy.
Article
Biochemistry & Molecular Biology
Ran Wei, Huihui Zhang, Jianzhong Cao, Dailei Qin, Shengping Li, Wuguo Deng
Summary: In this study, the researchers used a gene interaction network to explore the subtypes of pancreatic cancer and found that these subtypes exhibit significant heterogeneity in clinical features, genetic mutations, immune cell infiltration, and treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Xinglong Geng, Hongze Chen, Liang Zhao, Jisheng Hu, Wenbo Yang, Guanqun Li, Chundong Cheng, Zhongjie Zhao, Tao Zhang, Le Li, Bei Sun
Summary: The roles of CAFs in PDAC are diverse, with different subtypes supporting or inhibiting cancer cell proliferation. As research progresses, CAFs may be a key factor in the treatment of pancreatic cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Weiyu Ge, Jingyu Ma, Tiebo Mao, Haiyan Xu, Xiaofei Zhang, Shumin Li, Yongchao Wang, Jiayu Yao, Ming Yue, Feng Jiao, Yu Wang, Meng Zhuo, Ting Han, Jiong Hu, Xiao Zhang, Jiujie Cui, Liwei Wang
Summary: This study provides insights into the gene patterns, immune and mutational landscape characteristics, and their relationships in different locations of pancreatic adenocarcinoma (PDAC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Gangping Tu, Wenzhe Gao, Ying Li, Yating Dian, Bingyang Xue, Li Niu, Xiao Yu, Hongwei Zhu
Summary: S100A16, highly expressed in pancreatic cancer tissues, might be associated with poor prognosis. By analyzing gene expression differences, clinical characteristics, and establishing a risk score system, the study successfully predicted the survival time of patients with PDAC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jing Sun, Shuai Zhu
Summary: Through coexpression analysis and the LncTarD database, a set of hypoxia-related long noncoding RNAs (lncRNAs) were identified, and a prognostic model was constructed. This model showed excellent performance in predicting the prognosis of pancreatic cancer patients. Overexpression of TSPOAP1-AS1, a hypoxia-related lncRNA, attenuated the proliferation and invasion of pancreatic cancer cells. HIF-1a bound to the promoter of TSPOAP1-AS1 and impaired its transcription under hypoxia. In conclusion, the hypoxia-related lncRNA assessment model could be a potential strategy for prognostic prediction in pancreatic cancer. The fourteen lncRNAs contained in the model could be helpful for uncovering the mechanisms of pancreatic tumorigenesis.
Article
Polymer Science
Dezhen Wu, Lenning Shen, Dong Zhang, Tao Zhu, Jie Zheng, Xiong Gong
Summary: The power conversion efficiency (PCE) of polymer solar cells (PSCs) with a bulk heterojunction (BHJ) structure can be enhanced by incorporating Fe3O4 magnetic nanoparticles (MNPs) and an external magnetic field (EMF). The coercive electric field within the Fe3O4 MNPs generated by the EMF facilitates charge generation and accelerates charge carrier transport, leading to an improvement in PCE.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Letter
Clinical Neurology
Yuhang Diao, Hongtao Rong, Tao Zhu
ACTA NEUROLOGICA BELGICA
(2023)
Article
Energy & Fuels
Feifei Yin, Baisheng Nie, Jie Wu, Yu Yang, Yueying Wei, Tao Zhu
Summary: Recycling methane from ventilation air can effectively reduce greenhouse gas emissions, improve gas utilization efficiency, and develop green mines. The regenerative oxidation properties of ventilation air methane (VAM) blending with dimethyl ether (DME) in a thermal reverse flow reactor were investigated. The addition of DME greatly enhanced methane conversion by shortening the ignition delay time and lowering the ignition temperature.
Article
Chemistry, Multidisciplinary
Hao Li, Yali Yang, Shiqing Deng, Hui Liu, Tianyu Li, Yuzhu Song, He Bai, Tao Zhu, Jiaou Wang, Huanhua Wang, Er-Jia Guo, Xianran Xing, Hongjun Xiang, Jun Chen
Summary: Regulating the magnetic properties of multiferroics enables their potential application in spintronic devices. By utilizing oxygen defect engineering, we significantly enhanced the room temperature ferromagnetism of a representative ferrite, EuFeO3. Our findings suggest that the decrease in Fe-O-Fe bond angles caused by oxygen vacancies strengthens magnetic interactions and tilts Fe spins, leading to an approximately five-fold increase in saturation magnetization. Furthermore, we established the internal relationship between magnetism and oxygen vacancies by illustrating how magnetic structure and magnitude change with varying vacancy configuration and concentration. This strategy for regulating magnetic properties has broad applicability to various functional oxide materials.
Article
Multidisciplinary Sciences
Yu Long, Qiang Wu, Zhenghu Chang, Ai Liu, Yuanjie Yu, Shiyun Dai, Peng Cai, Ligang Huang, Lei Gao, Tao Zhu
Summary: In this study, the internal evolution of dissipative solitons in polarization space is experimentally observed using the division-of-amplitude method combined with dispersive Fourier transform techniques. The hidden asymmetry in polarization space is revealed, which is important for theoretical modeling and applications in polarization spectroscopy.
Article
Immunology
Jinping Wang, Yaoxin Yang, Jin Liu, Jingxuan Qiu, Donghang Zhang, Mengchan Ou, Yi Kang, Tao Zhu, Cheng Zhou
Summary: The expression and function of NALCN in the DG were reduced in LPS-treated mice, and only inactivation of NALCN in the ventral DG produced depressive-like behaviors. These results suggest that the expression of NALCN in ventral DG glutamatergic neurons regulates depressive-like behaviors and susceptibility. Therefore, NALCN in glutamatergic neurons of the ventral DG may serve as a molecular target for rapid antidepressant drugs.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Medicine, General & Internal
Jing Sun, Zhilan Yang, Tao Zhu, Zhihong Jiang, Xiuli Zheng, Chunlian Li, Xiaoxia Cao
Summary: This study aimed to evaluate the impact of organizational justice on psychological distress and discuss the findings in collectivist culture. The results showed that interpersonal injustice and distributive injustice have an important influence on psychological distress in Chinese culture. Nursing managers should pay attention to the recognition and respect for subordinates by nurses, and be aware of the potential negative relationship between leaders and nurses that could harm their mental health.
Review
Anatomy & Morphology
Keyu Xie, Xu Cheng, Tao Zhu, Donghang Zhang
Summary: The somatosensory neurons in the dorsal root ganglion (DRG) detect peripheral stimuli and transmit them into the central nervous system. Recent advances in single-cell sequencing have provided insights into the composition and heterogeneity of DRG neurons in humans and rodents. This review summarizes the current literature on single-cell transcriptomic profiling of DRG to understand its molecular transcriptomes, cell types, and functional annotations.
FRONTIERS IN NEUROANATOMY
(2023)
Review
Cell Biology
Yong Qiu, Chunheng Mo, Shiyu Xu, Lu Chen, Wanlin Ye, Yi Kang, Guo Chen, Tao Zhu
Summary: The blood-brain barrier (BBB) is a crucial barrier that separates the central nervous system from the periphery, consisting of endothelial cells, pericytes, astrocytes, synapses, and tight junction proteins. During the perioperative period, anesthesia and surgical procedures pose stress on the body, leading to potential blood-brain barrier damage and brain metabolism dysfunction. The destruction of the blood-brain barrier during the perioperative period is closely associated with cognitive impairment and increased risk of postoperative mortality, hindering the enhancement of recovery after surgery. The specific pathophysiological processes and mechanisms underlying blood-brain barrier damage during the perioperative period have not been fully elucidated, but changes in blood-brain barrier permeability, inflammation and neuroinflammation, oxidative stress, ferroptosis, and intestinal dysbiosis may be involved. This review aims to summarize the research progress on perioperative blood-brain barrier damage, its potential adverse effects, and molecular mechanisms to provide insights for the study of brain function homeostasis and precision anesthesia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Physics, Applied
Weide Kang, Qiang Wu, Yulong Cao, Xinger Wang, Kaixiang Cao, Lei Gao, Tao Zhu
Summary: The optical field distributions of CFBGs are investigated using the finite element method and experimentally verified. It is found that the reflective locations of the evanescent field and the internal field distributions move linearly along the fiber grating region as the incident wavelength increases. The exploration of the field distributions of CFBGs provides more information for subsequent analysis and fabrication.
APPLIED PHYSICS LETTERS
(2023)
Article
Behavioral Sciences
Tao Zhu, Bingran Chen, Han Han, Xu Lu, Zhuo Chen, Ting Ye, Hui Zhao, Meng Zheng, Chao Huang
Summary: Recent studies have shown that compounds stimulating microglia could be potential drugs for depression treatment due to their ability to reverse depression-like behaviors. This study investigated the therapeutic effect of zymosan A, a Saccharomyces cerevisiae cell wall preparation, on depression in mice. The results demonstrated that a single injection of zymosan A before behavioral tests could reverse chronic stress-induced depression-like behaviors, with the effect becoming significant at 5 and 8 hours and lasting for at least 7 days.
BEHAVIOURAL PHARMACOLOGY
(2023)
Article
Agronomy
Weiping Lou, Yanxia Zhao, Xueliu Huang, Tao Zhu, Ming Yang, Shengrong Deng, Zhuding Zhou, Yi Zhang, Qing Sun, Sining Chen
Summary: This research quantified the frost risk in China's largest green tea production area and developed a new frost risk index, finding that elevation is the main factor associated with frost risk. In plain areas, the risk and percentage of all frost-damaged tea buds did not significantly change with elevation, while in hilly areas, the risk significantly increased with elevation, but the percentage of frost-damaged tea buds significantly decreased. This trend is beneficial for tea production in hilly areas.
EUROPEAN JOURNAL OF AGRONOMY
(2023)
Article
Chemistry, Physical
Xinxin Dong, Tao Zhu, Guoqing Liu, Jinxuan Chen, Hongfei Li, Jun Sun, Xiaoyu Gu, Sheng Zhang
Summary: Coating commercial polypropylene separators with three brominated flame retardants greatly improves the flame retardancy of lithium-sulfur batteries and reduces the self-extinguishing time of the electrolyte through radical elimination mechanism. Oxygen-containing flame retardants exhibit a stronger adsorption capacity and are more advantageous in mitigating the shuttle effect and enhancing the cycle and rate performance of the batteries. This simple coating strategy offers a competitive option for large-scale production of high-safety lithium-sulfur batteries.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Xueying Zhang, Rui Gao, Changteng Zhang, Yi Teng, Hai Chen, Qi Li, Changliang Liu, Jiahui Wu, Liuxing Wei, Liyun Deng, Lining Wu, Shixin Ye-Lehmann, Xiaobo Mao, Jin Liu, Tao Zhu, Chan Chen
Summary: Chronic pain is often associated with cognitive decline, and Toll-like receptor 3 (TLR3) plays a crucial role in memory and learning. This study found that TLR3 levels increased in hippocampal neurons of mice with chronic pain. Furthermore, TLR3 knockout and TLR3-specific neuronal knockdown mice showed improved cognitive function and reduced inflammation and apoptosis. The presence of double-stranded RNAs (dsRNAs), specifically in the sciatic nerve, serum, and hippocampus, activated TLR3, leading to impaired synaptic plasticity and cognitive impairment.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Optics
Ligang Huang, Shunli Liu, Bowen Zheng, Yanxiang Zhao, Laiyang Dang, Lei Gao, Wei Huang, Guolu Yin, Tao Zhu
Summary: A narrowband fast tunable acousto-optic add-drop filter is proposed and demonstrated, which is based on the acoustically induced birefringence of dispersion compensating fiber and covers wavelengths from 1510 nm to 1590 nm. Single-wavelength filtering is achieved with a bandwidth of around 5 nm by peak fusion of the nearly degenerated coupling of the vector mode group with an acousto-optic interaction length of smaller than 5 cm. The constructed filter has reconfigurable band-pass and band-rejection filtering characteristics, and offers advantages such as narrow band, fast tuning speed, single wavelength, compact size, simple fabrication, and zero frequency shift. It has potential applications in the fields of tunable lasers, wavelength division multiplexing optical communication, and optical signal processing.
OPTICS AND LASER TECHNOLOGY
(2023)
