Article
Biochemistry & Molecular Biology
Xuejun Li, Li Dong, Ang Li, Jianxun Yi, Marco Brotto, Jingsong Zhou
Summary: Mitochondrial defects in motor neurons are pathological hallmarks of ALS. This study shows that butyrate treatment improves mitochondrial function in ALS mice and identifies the activation of the PGC1 alpha signaling axis as a potential molecular mechanism underlying the beneficial effects of butyrate.
Article
Chemistry, Multidisciplinary
Mingle Li, Kalayou Hiluf Gebremedhin, Dandan Ma, Zhongji Pu, Tao Xiong, Yunjie Xu, Jong Seung Kim, Xiaojun Peng
Summary: The article introduces a conditionally activatable photoredox catalysis method, which achieves more effective tumor treatment through site-specific photoredox. This approach enables control of photoresponsivity while ensuring biocompatibility and safety.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Multidisciplinary Sciences
Elisa B. Randi, Karim Zuhra, Laszlo Pecze, Theodora Panagaki, Csaba Szabo
Summary: In mammalian cells, cyanide exhibits a biphasic effect on mitochondrial Complex IV activity, stimulating it at low concentrations and inhibiting it at higher concentrations. Low levels of cyanide lead to increased cell proliferation and ATP production, while higher levels result in inhibition of cellular bioenergetics. The presence of cyanide-producing enzymes in mammalian cells suggests a regulatory role for endogenous cyanide.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Jaylyn Waddell, Rehana Khatoon, Tibor Kristian
Summary: The dynamic properties and symbiotic nature of mitochondrion make it unique among other organelles, resulting in an active exchange of metabolites and cofactors. The energy metabolism of mitochondria heavily relies on the cofactor nicotinamide adenine dinucleotide (NAD), which is essential for respiratory and TCA cycle enzymes. This review explores NAD synthesis pathways, degradation enzymes, subcellular localization, and transport mechanisms, with a focus on mitochondria. The impact of pathologic depletion of mitochondrial NAD pools on post-translational modifications of mitochondrial proteins and its role in neurodegeneration is also discussed. Understanding the physiological constraints and mechanisms of NAD maintenance and exchange between subcellular compartments is essential due to NAD's broad effects and roles in health and disease.
Review
Biochemistry & Molecular Biology
Shuting Guan, Li Zhao, Ruiyun Peng
Summary: Mitochondrial supercomplexes, consisting of enzyme complexes and electron carriers, play a crucial role in improving the efficiency of mitochondrial respiratory chain and maintaining cellular metabolism homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anna Weiser, Aurelle Hermant, Flavien Bermont, Federico Sizzano, Sonia Karaz, Pilar Alvarez-Illera, Jaime Santo-Domingo, Vincenzo Sorrentino, Jerome N. Feige, Umberto De Marchi
Summary: Regulation of mitochondrial redox balance is crucial for cell signaling, but the connection between the redox state and cell conditions is not well understood. The study found that activation of the MCU protein modulates mitochondrial redox state, leading to mitochondrial reduction and improved respiratory capacity and mobility. By bypassing MCU, similar benefits can be achieved by directly reducing mitochondrial proteins. This research demonstrates the importance of MCU in regulating mitochondrial redox balance and its effects on respiratory and mobility functions.
Article
Plant Sciences
Aprajita Kumari, Vemula Chandra Kaladhar, Nidhi Yadav, Pooja Singh, Kishorekumar Reddy, Kapuganti Jagadis Gupta
Summary: The location of NO production in mitochondrial cytochrome c oxidase and its role in mitochondrial biogenesis were investigated in Arabidopsis seedlings under osmotic stress and recovery. Osmotic stress reduced growth and mitochondrial number while increasing NO production. Nitrite application stimulated NO production and mitochondrial number in a NO-deficient mutant. COX6b(-)3 and COA6-L subunits were induced during osmotic stress and mutants impaired in these subunits showed reduced NO production and mitochondrial biogenesis. The COX6b-3 and COA6-L subunits interacted with a VQ27 motif-containing protein in the presence of NO, and a vq27 mutant displayed impaired mitochondrial biogenesis.
PLANT CELL AND ENVIRONMENT
(2023)
Review
Cell Biology
Md Yousuf Ali, Claudia R. Oliva, Susanne Flor, Corinne E. Griguer
Summary: Iron is crucial for cellular processes, but maintaining iron homeostasis is essential for balanced cellular signaling and disease prevention. Mitoferrins, as the principal iron importers in human cell mitochondria, play a critical role in maintaining cytosolic and mitochondrial iron homeostasis.
Review
Biochemistry & Molecular Biology
Florian Beignon, Naig Gueguen, Helene Tricoire-Leignel, Cesar Mattei, Guy Lenaers
Summary: Understanding temperature production and regulation in endotherm organisms is a crucial challenge. Mitochondria can act as cellular radiators, controlling heat production and cell temperature. Considering these new thermic paradigms, we discuss conventional wisdom linking mitochondrial functions to cellular thermogenesis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Bo Zou, Qianqian Yu, Lele Shao, Yingying Sun, Xingmin Li, Ruitong Dai
Summary: Lipid molecules play a crucial role in mitochondria-mediated apoptosis. This study reveals that the levels of mitochondrial lipids increase during early postmortem, accelerating apoptosis in beef muscle. The psoas major muscle has a higher degree of apoptosis and more severe muscle oxidation and antioxidant system damage compared to the longissimus lumborum muscle.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Saurabh Mishra, Nicole Welch, Manikandan Karthikeyan, Annette Bellar, Ryan Musich, Shashi Shekhar Singh, Dongmei Zhang, Jinendiran Sekar, Amy H. Attaway, Aruna Chelluboyina, Shuhui Wang Lorkowski, Sanjoy Roychowdhary, Ling Li, Belinda Willard, Jonathan D. Smith, Charles L. Hoppel, Vidula Vachharajani, Avinash Kumar, Srinivasan Dasarathy
Summary: Perturbed metabolism of ammonia causes mitochondrial dysfunction and senescence. Sirtuins delay senescence and their pathways are enriched during hyperammonemia. Hyperammonemia leads to decreased Sirt3 expression, increased protein acetylation, and lower redox status.
Article
Biochemistry & Molecular Biology
Anna Shteinfer-Kuzmine, Shirel Argueti-Ostrovsky, Marcel F. Leyton-Jaimes, Uttpal Anand, Salah Abu-Hamad, Ran Zalk, Varda Shoshan-Barmatz, Adrian Israelson
Summary: This study suggests that the interaction between VDAC1 and SOD1 is involved in the pathogenesis of ALS. By inhibiting VDAC1 oligomerization, it is possible to reduce cell apoptosis and related processes caused by mutant SOD1, thus improving muscle function in ALS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Valentina Loconte, Kate L. White
Summary: This review highlights the use of soft X-ray tomography (SXT) as a high-throughput approach to quantify mitochondrial structure and function under various cellular conditions. SXT allows unbiased, label-free imaging of intact whole cells and provides unique information about organelles.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Anna Fernandez Bernal, Natalia Mota, Reinald Pamplona, Estela Area-Gomez, Manuel Portero-Otin
Summary: Amyotrophic lateral sclerosis (ALS) is characterized by the death of motor neurons (MNs), and dysfunction in mitochondrial-associated membranes (MAMs) may play a crucial role in the cellular disarrangements in ALS, including dysregulations in lipid metabolism and calcium homeostasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Mary Adebayo, Seema Singh, Ajay Pratap Singh, Santanu Dasgupta
Summary: Mitochondria are dynamic organelles inherited maternally, fulfilling cellular energy demand and playing roles in cell signaling, metabolism, and apoptosis. Maintenance of mitochondrial integrity and homeostasis through fusion and fission is crucial, and imbalance can lead to various diseases.
Article
Veterinary Sciences
Jo A. Crum, Daniel G. Mead, Mark W. Jackwood, Jamie E. Phillips, David E. Stallknecht
JOURNAL OF WILDLIFE DISEASES
(2019)
Article
Ecology
Lucas M. Ferreri, Lucia Ortiz, Ginger Geiger, Gonzalo P. Barriga, Rebecca Poulson, Ana Silvia Gonzalez-Reiche, Jo Anne Crum, David Stallknecht, David Moran, Celia Cordon-Rosales, Daniela Rajao, Daniel R. Perez
ECOLOGY AND EVOLUTION
(2019)
Article
Veterinary Sciences
Charlie S. Bahnson, Rebecca L. Poulson, Laura P. Hollander, Jo A. Crum Bradley, David E. Stallknecht
JOURNAL OF WILDLIFE DISEASES
(2020)
Article
Veterinary Sciences
David E. Stallknecht, Alinde Fojtik, Deborah L. Carter, Jo Anne Crum-Bradley, Daniel R. Perez, Rebecca L. Poulson
Summary: This study investigated the prevalence of immune response to influenza A virus (IAV) in migrating mallards in Northwest Minnesota. The results showed a high level of previous infection with IAV early in the fall migration season and a broadening of the antibody response with age. The findings suggest the importance of population immunity in waterfowl populations and the potential for the establishment of introduced IAV.
VETERINARY SCIENCES
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Jo Anne Crum, Victoria Del Gaizo Moore