Article
Biochemistry & Molecular Biology
Zhigang Hu, Xiaolin Liu
Summary: This study compared and analyzed the transcriptomes and metabolomes of Pekin duck breast muscle during the embryonic stage, revealing the important roles of metabolic pathways and candidate genes in muscle development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Shangtao Cao, Huijian Feng, Hongyan Yi, Mengjie Pan, Lihui Lin, Yao Santo Zhang, Ziyu Feng, Weifang Liang, Baomei Cai, Qi Li, Zhi Xiong, Qingmei Shen, Minjing Ke, Xing Zhao, Huilin Chen, Qina He, Mingwei Min, Quanyou Cai, He Liu, Jie Wang, Duanqing Pei, Jiekai Chen, Yanlin Ma
Summary: In this study, the early development of human lung in embryos at weeks 4-8 post fertilization was investigated using single-cell RNA sequencing, and a transcriptomic atlas of 169,686 cells was obtained. Gene expression patterns of proximal and distal epithelia were observed at week 4, and novel transcriptional regulators of proximal and distal patterning, as well as a spatially specific niche, were identified. The study also revealed the cell fate bifurcation and maturation of airway and vascular smooth muscle progenitor cells at the early stage of lung development.
Article
Biochemistry & Molecular Biology
Ram Wagle, Young-Han Song
Summary: By conducting radiation experiments on Drosophila embryos, it was found that neural stem cells in the embryos exhibit strong resistance to high doses of radiation, while other cells are more susceptible to apoptosis. After low-dose irradiation, the number of neural stem cells decreased, and the locomotor ability of surviving adults was also affected.
MOLECULAR & CELLULAR TOXICOLOGY
(2022)
Article
Cell Biology
Anna C. Koegler, Yacine Kherdjemil, Katharina Bender, Adam Rabinowitz, Raquel Marco-Ferreres, Eileen E. M. Furlong
Summary: Many developmental regulators have complex and context-specific roles in different tissues and stages, making the dissection of their function extremely challenging. The improved light-inducible nuclear export system (iLEXY) enables rapid, efficient, and reversible nuclear protein depletion in embryos, and is generalizable to proteins of diverse sizes and functions, highlighting its power in dissecting the function of pleiotropic factors during embryogenesis with unprecedented temporal precision.
DEVELOPMENTAL CELL
(2021)
Article
Pediatrics
Mitsuyuki Nakata, Hiroaki Honda, Atsushi Iwama, Keita Terui, Shugo Komatsu, Ryohei Shibata, Tomoro Hishiki
Summary: This study aimed to investigate the role of Wnt5a in anorectal development and its contribution to the development of the striated muscle complex (SMC). Using a conditional knockout mouse model, the researchers found that Wnt5a plays a critical role in anal opening and SMC formation at a very early stage of embryonic development.
PEDIATRIC SURGERY INTERNATIONAL
(2022)
Article
Biology
Monika Zmojdzian, Binoj Dhanarajan, Krzysztof Jagla, Rajaguru Aradhya
Summary: Studying the behavior of adult muscle stem cells in repairing injured tissues is crucial for understanding their mechanisms. Model organisms like Drosophila provide valuable information on the signals that regulate muscle stem cells and their interactions. With its genetic tools and similarities to vertebrates, Drosophila is widely used for stem cell research.
Article
Biochemical Research Methods
Abibatou Mbodj, E. Hilary Gustafson, Lucia Ciglar, Guillaume Junion, Aitor Gonzalez, Charles Girardot, Laurent Perrin, Eileen E. M. Furlong, Denis Thieffry
PLOS COMPUTATIONAL BIOLOGY
(2016)
Review
Cell Biology
Krzysztof Jagla, Benoit Kalman, Thomas Boudou, Sylvie Henon, Sabrina Batonnet-Pichon
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Jadwiga Jablonska, Magda Dubinska-Magiera, Teresa Jagla, Krzysztof Jagla, Malgorzata Daczewska
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)
Article
Cell Biology
Lucie Picchio, Vincent Legagneux, Stephane Deschamps, Yoan Renaud, Sabine Chauveau, Luc Paillard, Krzysztof Jagla
DISEASE MODELS & MECHANISMS
(2018)
Review
Biochemistry & Molecular Biology
Anissa Souidi, Monika Zmojdzian, Krzysztof Jagla
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Review
Biochemistry & Molecular Biology
Teresa Jagla, Magda Dubinska-Magiera, Preethi Poovathumkadavil, Malgorzata Daczewska, Krzysztof Jagla
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biology
Lilia Laddada, Krzysztof Jagla, Cedric Soler
Article
Developmental Biology
Guillaume Lavergne, Monika Zmojdzian, Jean Philippe Da Ponte, Guillaume Junion, Krzysztof Jagla
Article
Biology
Emilie Auxerre-Plantie, Masayuki Nakamori, Yoan Renaud, Aline Huguet, Caroline Choquet, Cristiana Dondi, Lucile Miquerol, Masanori P. Takahashi, Genevieve Gourdon, Guillaume Junion, Teresa Jagla, Monika Zmojdzian, Krzysztof Jagla
Article
Developmental Biology
Cristiana Dondi, Benjamin Bertin, Jean-Philippe Da Ponte, Inga Wojtowicz, Krzysztof Jagla, Guillaume Junion
Summary: The formation of the cardiac tube involves complex morphogenetic processes, including the collective migration of cardiac cells. CAP and MSP300 have been identified as novel actors in this process, playing a crucial role in the correct alignment of cardioblasts for coordinated migration. Their involvement in linking focal adhesion sites to nuclei via the actin cytoskeleton maintains post-mitotic state and correct alignment of cardioblasts.
Article
Biochemistry & Molecular Biology
Junaid Akhtar, Yoan Renaud, Steffen Albrecht, Yad Ghavi-Helm, Jean-Yves Roignant, Marion Silies, Guillaume Junion
Summary: m(6)A RNA modification regulates RNAP II pausing in Drosophila cells, affecting pause release, Ser2P occupancy, and nascent RNA transcription. The m(6)A-mediated gene regulation adds another layer to the control of gene expression.
Article
Multidisciplinary Sciences
Benjamin Bertin, Yoan Renaud, Teresa Jagla, Guillaume Lavergne, Cristiana Dondi, Jean-Philippe Da Ponte, Guillaume Junion, Krzysztof Jagla
Summary: The study identified Gelsolin and dCryAB as important factors in the development of Drosophila LT muscles, affecting muscle size and preventing muscle splitting. These findings offer initial insights into the still unknown mechanisms of pathological muscle splitting commonly detected in human dystrophic muscles.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Guillaume Junion, Krzysztof Jagla
Summary: Drosophila embryonic somatic muscles provide a simple model system to study the gene regulatory networks that control cell type diversification. The expression of specific transcription factor codes and downstream effector genes progressively define the properties of muscle fibers, such as fusion program, attachment, and innervation.
EXPERIMENTAL CELL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Junaid Akhtar, Margot Lugoboni, Guillaume Junion
Summary: RNA modifications, particularly m(6)A modification, play a critical role in regulating gene expression post-transcriptionally. They are crucial for normal development and physiology, affecting mRNA stability, translation, and other processes. Recent insights also suggest a bidirectional impact between m(6)A machinery and transcription/chromatin signature.
TRANSCRIPTION-AUSTIN
(2021)
Article
Developmental Biology
Monika Zmojdzian, Svetlana de Joussineau, Jean Philippe Da Ponte, Krzysztof Jagla