Article
Urology & Nephrology
Gregory J. Nason, Khaled Ajib, Guan Hee Tan, Dixon T. S. Woon, George T. Christakis, Robert K. Nam
Summary: This study evaluated the perioperative morbidity and long-term oncological outcomes of radical nephrectomy with resection of vena cava thrombus using a combined surgical approach. The surgery showed some morbidity and mortality, but remains a safe and effective strategy for advanced RCC patients who would otherwise require palliative management.
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Weidong Yan, Sizhe Gao, Qiaoni Zhang, Jiachen Qi, Gang Liu, Yuan Teng, Jian Wang, Shujie Yan, Bingyang Ji
Summary: This study found that administration of AdipoRon, a small-molecule adiponectin receptor agonist, could inhibit neuroinflammation following DHCA by improving vital signs, attenuating proinflammatory cytokines, inhibiting microglial activation, and promoting their transition to an anti-inflammatory state through the AMPK/NF-kappa B pathway.
Article
Cardiac & Cardiovascular Systems
Mahmoud Alhussaini, Matheus P. Falasa, Eric I. Jeng, Tomas Martin, Torben K. Becker, George J. Arnaoutakis, Amber Fillion, Dan Neal, Thomas M. Beaver
Summary: DHCA can be used for combined repair of aortic arch and descending thoracic aortic aneurysm via left thoracotomy without significant increase in major adverse outcomes compared to non-DHCA group.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Multidisciplinary Sciences
Muhammed Shariff, Aksharkumar Dobariya, Obada Albaghdadi, Jacob Awkal, Hadi Moussa, Gabriel Reyes, Mansur Syed, Robert Hart, Cameron Longfellow, Debra Douglass, Tarek Y. El Ahmadieh, Levi B. Good, Vikram Jakkamsetti, Gauri Kathote, Gus Angulo, Qian Ma, Ronnie Brown, Misha Dunbar, John M. Shelton, Bret M. Evers, Sourav Patnaik, Ulrike Hoffmann, Amy E. Hackmann, Bruce Mickey, Matthias Peltz, Michael E. Jessen, Juan M. Pascual
Summary: Selective vascular access to the brain allows for the study of neural activity independent of somatic influences, and this research provides a method for fully regulating cerebral hemodynamics for the manipulation and study of brain activity.
SCIENTIFIC REPORTS
(2023)
Review
Anesthesiology
Samit Ghia, Andre Savadjian, Dawi Shin, Gabriele Diluozzo, Menachem M. Weiner, Himani Bhatt
Summary: Diseases affecting the aortic arch often require surgical intervention. Hypothermic circulatory arrest (HCA) is a safe approach for open aortic arch surgeries, providing neuroprotection by reducing cerebral metabolism and oxygen requirements. However, HCA comes with significant risks, such as neurologic dysfunction, stroke, and coagulopathy, requiring the cardiac anesthesiologist to have a complete understanding of surgical techniques, possible complications, and management strategies.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Review
Medicine, General & Internal
Lars J. Bjertnaes, Kristian Hindberg, Torvind O. Naesheim, Evgeny V. Suborov, Eirik Reierth, Mikhail Y. Kirov, Konstantin M. Lebedinskii, Torkjel Tveita
Summary: This systematic review and meta-analysis compared outcomes of rewarming after accidental hypothermic cardiac arrest with CPB or/and ECMO, finding that survival rate was significantly higher with ECMO than CPB, and for witnessed compared to unwitnessed cases, with avalanche victims having the lowest survival probability. Male sex, high initial body temperature, low pH, and high s-K+ levels were associated with lower chances of surviving.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Qiang Chen, Yu-Qing Lei, Jian-Feng Liu, Zeng-Chun Wang, Hua Cao
Summary: This study found that TPL improved neurobehavioral functions, reduced neuroinflammation and oxidative stress, and inhibited microglial activation and cell death in DHCA rats. Additionally, TPL activated the Nrf2 pathway and suppressed NF-kappa B activity, suggesting potential mechanisms for its neuroprotective effects.
Article
Cardiac & Cardiovascular Systems
Christian V. Ghincea, Devon A. Anderson, Yuki Ikeno, Gavriel F. Roda, Mohamed Eldeiry, Michael R. Bronsert, Kelly Aunkst, David A. Fullerton, T. Brett Reece, Muhammad Aftab
Summary: The study evaluated the utility of neurophysiologic intraoperative monitoring (NIOM) for early detection of stroke in aortic arch surgery, showing that NIOM has high sensitivity and specificity for early stroke detection but low positive predictive value, requiring careful interpretation of abnormal findings.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Kevin Pilarczyk, Bernd Panholzer, Katharina Huenges, Mohamed Salem, Toni Jacob, Jochen Cremer, Assad Haneya
Summary: This study investigates the role of new biomarkers in predicting acute kidney injury (AKI) after thoracic aortic surgery (TAS) with moderate hypothermic circulatory arrest (MHCA). The results show that Cystatin C is a highly sensitive and specific biomarker for predicting AKI even before surgery, while the predictive capacity of [TIMP-2]*[IGFBP7] is only moderate and inferior to that of serum creatinine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Katherine Giuliano, Eric Etchill, Xun Zhou, Cecillia Lui, Alejandro Suarez-Pierre, Rishi Sharma, Mary Ann Wilson, Mary E. Blue, Juan C. Troncoso, Sujatha Kannan, Michael Johnston, Anjali Sharma, Rangaramanujam M. Kannan, Willian A. Baumgartner, Jennifer Lawton
Summary: In a canine model, the N-methyl-D-aspartate receptor antagonist MK801 and its conjugate to dendrimer nanoparticles d-MK801 were found to provide neuroprotection after HCA, improving neurobehavioral and histopathology scores.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Masaki Kajimoto, Muhammad Nuri, Justin R. Sleasman, Kevin A. Charette, Branden R. Nelson, Michael A. Portman
Summary: This study demonstrated that inhaled NO (iNO) can reduce neuronal degeneration in the hippocampus and decrease microglial activation after deep hypothermic circulatory arrest (DHCA), potentially serving as a practical mode of neuroprotection for infants undergoing DHCA.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Ryumon Matsumoto, Toshiki Fujiyoshi, Kentaro Kamiya, Jun Matsubayashi, Shoji Fukuda, Toshiya Nishibe, Hitoshi Ogino
Summary: This report describes a patient who underwent two surgeries for primary and metastatic liposarcomas. The tumor located at the cavoatrial junction was successfully resected using cardiopulmonary bypass with hypothermic circulatory arrest. Despite the poor prognosis, the patient has survived for 8 years.
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Critical Care Medicine
Yael Levy, Alice Hutin, Fanny Lidouren, Nicolas Polge, Rocio Fernandez, Matthias Kohlhauer, Pierre-Louis Leger, Guillaume Debaty, Keith Lurie, Lionel Lamhaut, Bijan Ghaleh, Renaud Tissier
Summary: This study found that during early E-CPR, a MAP target above 80 mmHg is associated with higher carotid blood flow and improved cerebral autoregulation. However, this pattern is reversed after ROSC with a better hemodynamic status seen with standard MAP targets.
Article
Biology
Li Lei, Guan Xinliang, Gong Ming, Wang Xiaolong, Liu Yuyong, Liu Yang, Wu Zining, Lan Feng, Li Haiyang, Zhang Hongjia
Summary: The study investigated the impact of different types of hypothermic circulatory arrest on the coagulation system in a pig model. Results showed that deep hypothermic circulatory arrest led to more severe systemic activation of the coagulation system compared to moderate hypothermic circulatory arrest. It was concluded that moderate hypothermic circulatory arrest is more suitable for patients with coagulation dysfunction and extrinsic coagulation factor supplementation is more effective after deep hypothermic circulatory arrest.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Neurosciences
Ming-Huan Yu, Qin Yang, You-Peng Zhang, Jia-Hui Wang, Ren-Jian-Zhi Zhang, Zhi-Gang Liu, Xiao-Cheng Liu
Summary: This study investigated the effect of the cannabinoid agonist WIN55, 212-2 on brain injury in a rat model of deep hypothermic circulatory arrest (DHCA) in cardiac surgery. The results showed that WIN55, 212-2 attenuated histopathological injury of the hippocampus, reduced levels of proinflammatory cytokines, and increased levels of superoxide dismutase (SOD). WIN55, 212-2 also regulated the expression of apoptotic-related protein caspase-3 and cannabinoid receptor CB1R in the hippocampus. Therefore, WIN55, 212-2 administration alleviates DHCA-induced hippocampal injury through a CB1R-dependent mechanism.
Article
Cardiac & Cardiovascular Systems
Fernando Scudiero, Iacopo Muraca, Angela Migliorini, Rossella Marcucci, Matteo Pennesi, Lapo Mazzolai, Nazario Carrabba, Niccolo Marchionni, Pierluigi Stefano, Renato Valenti
Summary: This study compared the clinical outcomes of contemporary percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in the treatment of unprotected left main coronary artery disease (ULMCAD) in a real-world population and found that both methods showed similar long-term clinical outcomes.
JOURNAL OF INTERVENTIONAL CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Nazario Carrabba, Francesco Buonamici, Rocco Furferi, Monica Carfagni, Matteo Vannini, Renato Valenti, Alfredo Giuseppe Cerillo, Niccolo Marchionni, Pierluigi Stefano
Summary: This case study demonstrates the utilization of a 3D print model in the surgical management of apical LVA, resulting in optimal agreement between predicted and surgical residual LV volumes, leading to improved clinical symptoms and outcomes for the patient.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Infectious Diseases
Valentina Scheggi, Silvia Menale, Barbara Tonietti, Costanza Bigiarini, Jacopo Giovacchini, Stefano Del Pace, Nicola Zoppetti, Bruno Alterini, Pier Luigi Stefano, Niccolo Marchionni
Summary: This study aimed to identify predictors of cerebral septic embolism in patients with infective endocarditis and evaluate the role of surgery. Results showed that patients with large vegetations, mitral valve infection, and Staphylococcus aureus infection were more likely to have cerebral embolism. Vegetation length was found to be an independent predictor of cerebral embolism. Patients with neurologic complications were often excluded from surgery despite indications.
BMC INFECTIOUS DISEASES
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
V Balducci, M. Gencarelli, A. Laurino, V Spinelli, P. Stefano, E. Cerbai, L. Sartiani
CARDIOVASCULAR RESEARCH
(2022)
Article
Geriatrics & Gerontology
Samuele Baldasseroni, Mauro Di Bari, Pierluigi Stefano, Alessandra Pratesi, Enrico Mossello, Andrea Ungar, Stefano Del Pace, Francesco Orso, Andrea Herbst, Giulia Lucarelli, Carlo Fumagalli, Giuseppe Olivo, Niccolo Marchionni
Summary: This study aimed to investigate the predictors of in-hospital stay after elective cardiac surgery. Through preoperative evaluation of patients aged 75 years and older, it was found that assessment of physical performance has independent predictive ability for length of hospital stay.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sergio Bevilacqua, Carlo Pratesi, Michele F. Ostuni, Andrea Pecchioni, Elena Giacomelli, Alfredo G. Cerillo, Pierluigi Stefano
Summary: This study investigated the outcome of patients undergoing synchronous carotid endarterectomy and coronary and/or other cardiac surgery. The study found that synchronous surgery had an acceptable mortality and complication rate, even when combined with surgeries other than isolated coronary surgery. Cooperative patient general anesthesia during carotid endarterectomy was comparable to general anesthesia in this setting.
JOURNAL OF CARDIOVASCULAR SURGERY
(2022)
Article
Gastroenterology & Hepatology
Matteo Risaliti, Ilenia Bartolini, Claudia Campani, Umberto Arena, Carlotta Xodo, Valentina Adotti, Martina Rosi, Antonio Taddei, Paolo Muiesan, Amedeo Amedei, Giacomo Batignani, Fabio Marra
Summary: In a small cohort of patients with multifocal HCC, liver resection (LR) confers longer disease-free survival (DFS) compared with Trans-Arterial ChemoEmbolization (TACE), with similar overall survival (OS) and post-procedural morbidity.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Pierluigi Stefano, Alessia Argiro, Beatrice Bacchi, Luisa Iannone, Alenya Bertini, Mattia Zampieri, Alfredo Cerillo, Iacopo Olivotto
Summary: This article reviews the history of surgical treatment for obstructive hypertrophic cardiomyopathy (oHCM) over the past 60 years, taking into account the advancing knowledge of the pathophysiology of obstruction. The contribution of different surgical approaches to the field is assessed based on personal experience in Florence. Septal myectomy is the preferred treatment for patients with obstructive hypertrophic cardiomyopathy who remain symptomatic despite optimal medical treatment.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Nicoletta D'Ettore, Giorgio Iacopo Baldereschi, Chiara Di Filippo, Niccolo Marchionni, Pierluigi Stefano, Emanuele Cecchi
CARDIOVASCULAR INTERVENTION AND THERAPEUTICS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Carlo Fumagalli, Giulia Nardi, Francesca Bonanni, Giacomo Credi, Pierluigi Demola, Nazario Carrabba, Renato Valenti, Francesco Meucci, Pierluigi Stefano, Valentina Scheggi, Carlo Di Mario, Andrea Ungar, Samuele Baldasseroni, Niccolo Marchionni
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Article
Cell Biology
Lavinia Curini, Brunilda Alushi, Mary Roxana Christopher, Simone Baldi, Leandro Di Gloria, Pierluigi Stefano, Anna Lagana, Luisa Iannone, Herko Grubitzsch, Ulf Landmesser, Matteo Ramazzotti, Elena Niccolai, Alexander Lauten, Amedeo Amedei
Summary: This study aimed to investigate and characterize the presence of a valve microbiota and associated immune response in human calcific aortic valve disease (CAVD) for the first time. Calcified aortic valve (CAV) samples from twenty patients were used to assess infiltrating T cells and characterize the valve microbiota. The results showed the presence of infiltrating T lymphocytes, especially the T helper subset, in CAV samples. In addition, a tissue-associated microbiota was found in the CAV samples, which differed significantly between Italian and German patients, suggesting a potential correlation with cardiovascular risk factors.
Article
Medicine, General & Internal
Carlo Rostagno, Camilla Tozzetti, Enrico Carone, Pierluigi Stefano
Summary: This study aimed to evaluate the effects of radiofrequency ablation associated with mitral valve surgery on the recovery and long-term maintenance of sinus rhythm in elderly patients with atrial fibrillation (AF). The results showed that elderly patients had a similar rate of stable sinus rhythm maintenance compared to younger patients after the procedure. However, elderly patients required more frequent permanent pacing and had higher rates of hospitalizations and post-procedural atrial tachyarrhythmias.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
Alfredo Giuseppe Cerillo, Giulio Pellegrini, Pierluigi Stefano
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Bart Meuris, Jean-Christian Roussel, Michael A. Borger, Matthias Siepe, Pierluigi Stefano, Guenther Laufer, Thierry Langanay, Alexis Theron, Martin Grabenwoeger, Konrad Binder, Philippe Demers, Renzo Pessotto, Wouter van Leeuwen, Thierry Bourguignon, Sergio Canovas, Giovanni Mariscalco, Enrico Coscioni, Francois Dagenais, Olaf Wendler, Gianluca Polvani, Matthias Eden, Beate Botta, Peter Bramlage, Ruggero De Paulis
Summary: This study reports the 1-year safety and clinical outcomes of patients under 60 years old who underwent bioprosthetic surgical aortic valve intervention. The results showed good safety, excellent haemodynamic performance, and improved quality of life after the surgery.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
V. Scheggi, S. Menale, B. Tonietti, J. Giovacchini, C. Bigiarini, S. Del Pace, N. Zoppetti, B. Alterini, P. L. Stefano, N. Marchionni
EUROPEAN HEART JOURNAL
(2022)