The Lung Immune Response to NontypeableHaemophilus influenzae(Lung Immunity to NTHi)

A Brief Review of Chronic Obstructive Pulmonary Disease

(2016) James C Hogg   Canadian Respiratory Journal

Nontypeable Haemophilus influenzae Induces Sustained Lung Oxidative Stress and Protease Expression

(2015) Paul T. King et al.   PLoS One

T-Regulatory Cells and Programmed Death 1+T Cells Contribute to Effector T-Cell Dysfunction in Patients with Chronic Obstructive Pulmonary Disease

(2014) Suresh Gopi Kalathil et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Role of Bacteria in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis

(2014) Phillip L. Molyneaux et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages

(2014) H. J. Metcalfe et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Impacts of peroxisome proliferator-activated receptor-  activation on cigarette smoke-induced exacerbated response to bacteria

(2014) M. C. Morissette et al.   EUROPEAN RESPIRATORY JOURNAL

Cigarette Smoke Exposure Exacerbates Lung Inflammation and Compromises Immunity to Bacterial Infection

(2014) A. A. Lugade et al.   JOURNAL OF IMMUNOLOGY

Non-typeable Haemophilus influenzae, an under-recognised pathogen

(2014) Johan Van Eldere et al.   LANCET INFECTIOUS DISEASES

Children with Chronic Suppurative Lung Disease Have a Reduced Capacity to Synthesize Interferon-Gamma In Vitro in Response to Non-Typeable Haemophilus influenzae

(2014) Susan J. Pizzutto et al.   PLoS One

Impaired innate immune alveolar macrophage response and the predilection for COPD exacerbations

(2014) Charles S Berenson et al.   THORAX

Dectin-1 Is Expressed in Human Lung and Mediates the Proinflammatory Immune Response to Nontypeable Haemophilus influenzae

(2014) K. A. Heyl et al.   mBio

Cellular interaction of nontypeableHaemophilus influenzaetriggers cytotoxicity of infected type II alveolar cells via apoptosis

(2014) Manu Goyal et al.   Pathogens and Disease

Outgrowth of the Bacterial Airway Microbiome after Rhinovirus Exacerbation of Chronic Obstructive Pulmonary Disease

(2013) Philip L. Molyneaux et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Internalization and Trafficking of Nontypeable Haemophilus influenzae in Human Respiratory Epithelial Cells and Roles of IgA1 Proteases for Optimal Invasion and Persistence

(2013) Cara F. Clementi et al.   INFECTION AND IMMUNITY

Outer Membrane Protein P5 Is Required for Resistance of Nontypeable Haemophilus influenzae to Both the Classical and Alternative Complement Pathways

(2013) Charles V. Rosadini et al.   INFECTION AND IMMUNITY

Effect of Long-term, Low-Dose Erythromycin on Pulmonary Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis

(2013) David J. Serisier et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

IL-1 Receptor Regulates microRNA-135b Expression in a Negative Feedback Mechanism during Cigarette Smoke-Induced Inflammation

(2013) S. Halappanavar et al.   JOURNAL OF IMMUNOLOGY

Safety and Immunological Outcomes Following Human Inoculation With Nontypeable Haemophilus influenzae

(2013) Patricia L. Winokur et al.   JOURNAL OF INFECTIOUS DISEASES

Phagocytic Dysfunction of Human Alveolar Macrophages and Severity of Chronic Obstructive Pulmonary Disease

(2013) Charles S. Berenson et al.   JOURNAL OF INFECTIOUS DISEASES

Effect of pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) on outpatient antimicrobial purchases: a double-blind, cluster randomised phase 3–4 trial

(2013) Arto A Palmu et al.   LANCET INFECTIOUS DISEASES

Haemophilus influenzaeacquires vitronectin via the ubiquitous Protein F to subvert host innate immunity

(2013) Yu-Ching Su et al.   MOLECULAR MICROBIOLOGY

New anti-inflammatory targets for chronic obstructive pulmonary disease

(2013) Peter J. Barnes   NATURE REVIEWS DRUG DISCOVERY

Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1β — A Possible Pathway of Exacerbations in COPD

(2013) Johannes Rotta detto Loria et al.   PLoS One

Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis: a prospective study

(2013) James D Chalmers et al.   Lancet Respiratory Medicine

Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease

(2012) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Synergistic and feedback signaling mechanisms in the regulation of inflammation in respiratory infections

(2012) Wenzhuo Y Wang et al.   Cellular & Molecular Immunology

Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease

(2012) Paul T. King et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biological Roles of Nontypeable Haemophilus influenzae Type IV Pilus Proteins Encoded by the pil and com Operons

(2012) M. D. Carruthers et al.   JOURNAL OF BACTERIOLOGY

Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial

(2012) Conroy Wong et al.   LANCET

Non-typeable Haemophilus influenzae decreases cilia beating via protein kinase C epsilon

(2012) Kristina L Bailey et al.   RESPIRATORY RESEARCH

CombinedHaemophilus influenzaerespiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma

(2012) Ama-Tawiah Essilfie et al.   THORAX

Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality

(2012) Samy Suissa et al.   THORAX

Rhinovirus Attenuates Non-typeable Hemophilus influenzae-stimulated IL-8 Responses via TLR2-dependent Degradation of IRAK-1

(2012) Benjamin L. Unger et al.   PLoS Pathogens

Haemophilus influenzae and smoking-related obstructive airways disease

(2012) Cripps et al.   International Journal of Chronic Obstructive Pulmonary Disease

HIV-related bronchiectasis in children: an emerging spectre in high tuberculosis burden areas

(2011) R. Masekela et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Haemophilus influenzae Infections in the H. influenzae Type b Conjugate Vaccine Era

(2011) Aarti Agrawal et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Lifetime risk of developing chronic obstructive pulmonary disease: a longitudinal population study

(2011) Andrea S Gershon et al.   LANCET

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

Azithromycin for Prevention of Exacerbations of COPD

(2011) Richard K. Albert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD

(2011) John R. Erb-Downward et al.   PLoS One

Activation of Epidermal Growth Factor Receptor Is Required for NTHi-Induced NF-κB-Dependent Inflammation

(2011) Xiangbin Xu et al.   PLoS One

Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model

(2011) C. J. Harvey et al.   Science Translational Medicine

Haemophilus influenzae Infection Drives IL-17-Mediated Neutrophilic Allergic Airways Disease

(2011) Ama-Tawiah Essilfie et al.   PLoS Pathogens

Molecular Basis of Increased Serum Resistance among Pulmonary Isolates of Non-typeable Haemophilus influenzae

(2011) Shigeki Nakamura et al.   PLoS Pathogens

Non-Typeable Haemophilus influenzae Invasion and Persistence in the Human Respiratory Tract

(2011) Cara F. Clementi et al.   Frontiers in Cellular and Infection Microbiology

The T-Helper Cell Type 1 Immune Response to Gram-Negative Bacterial Infections Is Impaired in COPD

(2010) Jürgen Knobloch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cytotoxic T lymphocyte and natural killer cell responses to non-typeable Haemophilus influenzae

(2010) P. T. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

NontypeableHaemophilus influenzaeInitiates Formation of Neutrophil Extracellular Traps

(2010) Richard A. Juneau et al.   INFECTION AND IMMUNITY

Residual NADPH Oxidase and Survival in Chronic Granulomatous Disease

(2010) Douglas B. Kuhns et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disordered Microbial Communities in Asthmatic Airways

(2010) Markus Hilty et al.   PLoS One

Haemophilus influenzae and the complement system

(2010) Teresia Hallström et al.   TRENDS IN MICROBIOLOGY

Abrogation of nontypeable Haemophilus influenzae Protein D function reduces phosphorylcholine decoration, adherence to airway epithelial cells, and fitness in a chinchilla model of otitis media

(2010) Ryan W. Johnson et al.   VACCINE

Bacteria Challenge in Smoke-exposed Mice Exacerbates Inflammation and Skews the Inflammatory Profile

(2009) Gordon J. Gaschler et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of interferon gamma and CD40 ligation on intracellular monocyte survival of nontypeableHaemophilus influenzae 

(2009) PAUL KING et al.   APMIS

Prevalence, Incidence, and Lifetime Risk for the Development of COPD in the Elderly

(2009) Yannick M.T.A. van Durme et al.   CHEST

Oral Immunotherapy With Inactivated Nontypeable Haemophilus influenzae Reduces Severity of Acute Exacerbations in Severe COPD

(2009) Maharaj Kishore Tandon et al.   CHEST

Defective macrophage phagocytosis of bacteria in COPD

(2009) A. E. Taylor et al.   EUROPEAN RESPIRATORY JOURNAL

Nontypeable Haemophilus influenzae Clearance by Alveolar Macrophages Is Impaired by Exposure to Cigarette Smoke

(2009) P. Marti-Lliteras et al.   INFECTION AND IMMUNITY

Rhinovirus Disrupts the Barrier Function of Polarized Airway Epithelial Cells

(2008) Umadevi Sajjan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Streptococcus pneumoniae synergizes with nontypeable Haemophilus influenzae to induce inflammation via upregulating TLR2

(2008) Jae Lim et al.   BMC IMMUNOLOGY

Structural and Functional Lung Disease in Primary Ciliary Dyskinesia

(2008) Francesca Santamaria et al.   CHEST

Systemic humoral immunity to non-typeableHaemophilus influenzae

(2008) P. T. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

Mucosal immunization of mice with recombinant OMP P2 induces antibodies that bind to surface epitopes of multiple strains of nontypeable Haemophilus influenzae

(2008) K L Ostberg et al.   Mucosal Immunology

Haemophilus influenzae Lysate Induces Aspects of the Chronic Obstructive Pulmonary Disease Phenotype

(2007) Seyed Javad Moghaddam et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY