Fast vaccine design and development based on correlates of protection (COPs): Influenza as a trendsetter

An altered relationship of influenza vaccine-specific IgG responses with T cell immunity occurs with aging in humans

(2013) Ki Soo Kang et al.   CLINICAL IMMUNOLOGY

Immunological assessment of influenza vaccines and immune correlates of protection

(2013) Adrian Reber et al.   Expert Review of Vaccines

Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines

(2013) Gerlinde Obermoser et al.   IMMUNITY

Antibody Correlates and Predictors of Immunity to Naturally Occurring Influenza in Humans and the Importance of Antibody to the Neuraminidase

(2013) Robert B. Couch et al.   JOURNAL OF INFECTIOUS DISEASES

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

Safety and immunogenicity of an oral, replicating adenovirus serotype 4 vector vaccine for H5N1 influenza: a randomised, double-blind, placebo-controlled, phase 1 study

(2013) Marc Gurwith et al.   LANCET INFECTIOUS DISEASES

Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens

(2013) Richard D Antrobus et al.   MOLECULAR THERAPY

Receptor binding by an H7N9 influenza virus from humans

(2013) Xiaoli Xiong et al.   NATURE

Cellular immune correlates of protection against symptomatic pandemic influenza

(2013) Saranya Sridhar et al.   NATURE MEDICINE

Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus

(2013) Abdullah Assiri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccine-Induced Anti-HA2 Antibodies Promote Virus Fusion and Enhance Influenza Virus Respiratory Disease

(2013) S. Khurana et al.   Science Translational Medicine

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

(2013) S.-E. Bentebibel et al.   Science Translational Medicine

Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-γ T cell responses in humans

(2013) Wendy Peters et al.   VACCINE

H5N1 pathogenesis studies in mammalian models

(2013) Jessica A. Belser et al.   VIRUS RESEARCH

Role of T cell immunity in recovery from influenza virus infection

(2013) Jie Sun et al.   Current Opinion in Virology

Clearance of influenza virus infections by T cells: risk of collateral damage?

(2013) MLB Hillaire et al.   Current Opinion in Virology

Head-to-head comparison of an intradermal and a virosome influenza vaccine in patients over the age of 60

(2013) Filippo Ansaldi et al.   Human Vaccines & Immunotherapeutics

Intranasal vaccination with an inactivated whole influenza virus vaccine induces strong antibody responses in serum and nasal mucus of healthy adults

(2013) Akira Ainai et al.   Human Vaccines & Immunotherapeutics

Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity

(2013) Brian J. Laidlaw et al.   PLoS Pathogens

Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in Humans

(2012) Patrick J. Lillie et al.   CLINICAL INFECTIOUS DISEASES

Universal influenza vaccine: the holy grail?

(2012) Alan R Shaw   Expert Review of Vaccines

Reproducibility of assays for influenza vaccine immunogenicity determination: progress towards consistency

(2012) Ralf Wagner et al.   Expert Review of Vaccines

Mucosal immunity and nasal influenza vaccination

(2012) Markus A Rose et al.   Expert Review of Vaccines

Understanding the immune response to seasonal influenza vaccination in older adults: a systems biology approach

(2012) Nathaniel D Lambert et al.   Expert Review of Vaccines

The design and proof of concept for a CD8+ T cell-based vaccine inducing cross-subtype protection against influenza A virus

(2012) Amabel C L Tan et al.   IMMUNOLOGY AND CELL BIOLOGY

Advances in the development of universal influenza vaccines

(2012) Sarah C. Gilbert   Influenza and Other Respiratory Viruses

The consortium for the standardization of influenza seroepidemiology (CONSISE): a global partnership to standardize influenza seroepidemiology and develop influenza investigation protocols to inform public health policy

(2012) Maria D. Van Kerkhove et al.   Influenza and Other Respiratory Viruses

Safety and Immunogenicity of Multimeric-001—a Novel Universal Influenza Vaccine

(2012) Jacob Atsmon et al.   JOURNAL OF CLINICAL IMMUNOLOGY

T-Helper 1 Cells Elicited by H5N1 Vaccination Predict Seroprotection

(2012) Gabriel K. Pedersen et al.   JOURNAL OF INFECTIOUS DISEASES

Localized Mucosal Response to Intranasal Live Attenuated Influenza Vaccine in Adults

(2012) Maria Ines Barría et al.   JOURNAL OF INFECTIOUS DISEASES

Initial infectious dose dictates the innate, adaptive, and memory responses to influenza in the respiratory tract

(2012) Isabelle Marois et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Design of Escherichia coli-Expressed Stalk Domain Immunogens of H1N1 Hemagglutinin That Protect Mice from Lethal Challenge

(2012) G. Bommakanti et al.   JOURNAL OF VIROLOGY

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Sublingual Immunization with a Live Attenuated Influenza A Virus Lacking the Nonstructural Protein 1 Induces Broad Protective Immunity in Mice

(2012) Hae-Jung Park et al.   PLoS One

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

New technologies for new influenza vaccines

(2012) Alan Shaw   VACCINE

Randomized comparative study of the serum antihemagglutinin and antineuraminidase antibody responses to six licensed trivalent influenza vaccines

(2012) Robert B. Couch et al.   VACCINE

Development of VAX128, a recombinant hemagglutinin (HA) influenza-flagellin fusion vaccine with improved safety and immune response

(2012) David N. Taylor et al.   VACCINE

Synthetic Influenza vaccine (FLU-v) stimulates cell mediated immunity in a double-blind, randomised, placebo-controlled Phase I trial

(2012) Olga Pleguezuelos et al.   VACCINE

Influenza A vaccines using linear expression cassettes delivered via electroporation afford full protection against challenge in a mouse model

(2012) Xuefei Shen et al.   VACCINE

Advances and Future Challenges in Recombinant Adenoviral Vectored H5N1 Influenza Vaccines

(2012) Jianfeng Zhang   Viruses-Basel

Correlates of vaccine protection from influenza and its complications

(2012) Jonathan A. McCullers et al.   Human Vaccines & Immunotherapeutics

New technologies for influenza vaccines

(2012) Philip Dormitzer et al.   Human Vaccines & Immunotherapeutics

Pathogenesis of Influenza A/H5N1 Virus Infection in Ferrets Differs between Intranasal and Intratracheal Routes of Inoculation

(2011) Rogier Bodewes et al.   AMERICAN JOURNAL OF PATHOLOGY

Proteosome-adjuvanted intranasal influenza vaccines: advantages, progress and future considerations

(2011) David Burt et al.   Expert Review of Vaccines

A universal influenza vaccine: Where are we in the pursuit of this “Holy Grail”?

(2011) Wayne Rudolph et al.   Human vaccines & immunotherapeutics

Matrix-M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model

(2011) Gabriel Pedersen et al.   Influenza and Other Respiratory Viruses

Immune correlates of protection against influenza: challenges for licensure of seasonal and pandemic influenza vaccines, Miami, FL, USA, March 1-3, 2010

(2011) Lars R. Haaheim et al.   Influenza and Other Respiratory Viruses

Induction of Virus-Specific Cytotoxic T Lymphocytes as a Basis for the Development of Broadly Protective Influenza Vaccines

(2011) Marine L. B. Hillaire et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Cross-protective immunity against influenza pH1N1 2009 viruses induced by seasonal influenza A (H3N2) virus is mediated by virus-specific T-cells

(2011) M. L. B. Hillaire et al.   JOURNAL OF GENERAL VIROLOGY

Development and evaluation of an M2-293FT cell-based flow cytometric assay for quantification of antibody response to native form of matrix protein 2 of influenza A viruses

(2011) Weimin Zhong et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Live and Inactivated Influenza Vaccines Induce Similar Humoral Responses, but Only Live Vaccines Induce Diverse T-Cell Responses in Young Children

(2011) Daniel F. Hoft et al.   JOURNAL OF INFECTIOUS DISEASES

Influenza virus-like particles as a new tool for vaccine immunogenicity testing: Validation of a neuraminidase neutralizing antibody assay

(2011) Victor Gavrilov et al.   JOURNAL OF VIROLOGICAL METHODS

DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials

(2011) Julie E Ledgerwood et al.   LANCET INFECTIOUS DISEASES

Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis

(2011) Michael T Osterholm et al.   LANCET INFECTIOUS DISEASES

Systems biology of vaccination for seasonal influenza in humans

(2011) Helder I Nakaya et al.   NATURE IMMUNOLOGY

Oil-in-Water Emulsion Adjuvant with Influenza Vaccine in Young Children

(2011) Timo Vesikari et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hemagglutination Inhibition Antibody Titers as a Correlate of Protection for Inactivated Influenza Vaccines in Children

(2011) Steven Black et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Sublingual Immunization with M2-Based Vaccine Induces Broad Protective Immunity against Influenza

(2011) Byoung-Shik Shim et al.   PLoS One

Targeting B cell responses in universal influenza vaccine design

(2011) Kaval Kaur et al.   TRENDS IN IMMUNOLOGY

Registration of influenza vaccines for children in Europe

(2011) Marta Granström et al.   VACCINE

Cellular immune response in the presence of protective antibody levels correlates with protection against 1918 influenza in ferrets

(2011) Stéphane Pillet et al.   VACCINE

Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza–flagellin fusion vaccine (VAX125, STF2.HA1 SI)

(2011) David N. Taylor et al.   VACCINE

Safety and immunogenicity of a recombinant M2e–flagellin influenza vaccine (STF2.4xM2e) in healthy adults

(2011) Christine B. Turley et al.   VACCINE

Protective efficacy of a trivalent recombinant hemagglutinin protein vaccine (FluBlok®) against influenza in healthy adults: A randomized, placebo-controlled trial

(2011) John J. Treanor et al.   VACCINE

Immune responses to influenza virus infection

(2011) J.H.C.M. Kreijtz et al.   VIRUS RESEARCH

Intranasal Delivery of Influenza Subunit Vaccine Formulated with GEM Particles as an Adjuvant

(2010) Vinay Saluja et al.   AAPS Journal

Influenza vaccine responses in older adults

(2010) Janet E. McElhaney   AGEING RESEARCH REVIEWS

Potent CD8+ T-Cell Immunogenicity in Humans of a Novel Heterosubtypic Influenza A Vaccine, MVA-NP+M1

(2010) T. K. Berthoud et al.   CLINICAL INFECTIOUS DISEASES

Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine

(2010) Davide Corti et al.   JOURNAL OF CLINICAL INVESTIGATION

Universal Vaccine Based on Ectodomain of Matrix Protein 2 of Influenza A: Fc Receptors and Alveolar Macrophages Mediate Protection

(2010) K. El Bakkouri et al.   JOURNAL OF IMMUNOLOGY

Needle-free influenza vaccination

(2010) Jean-Pierre Amorij et al.   LANCET INFECTIOUS DISEASES

Influenza Vaccines for the Future

(2010) Linda C. Lambert et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Efficacy of Live Attenuated and Inactivated Influenza Vaccines in Children as a Function of Time Postvaccination

(2010) Christopher S. Ambrose et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

Clinical and immunologic predictors of influenza illness among vaccinated older adults

(2010) Zainab Shahid et al.   VACCINE

Qualitative and quantitative analyses of virtually all subtypes of influenza A and B viral neuraminidases using antibodies targeting the universally conserved sequences

(2010) Caroline Gravel et al.   VACCINE

Standardization and validation of assays determining cellular immune responses against influenza

(2010) Karlijn Gijzen et al.   VACCINE

Recombinant H1N1 virus-like particle vaccine elicits protective immunity in ferrets against the 2009 pandemic H1N1 influenza virus

(2010) Peter Pushko et al.   VACCINE

Phase 1 clinical trials of the safety and immunogenicity of adjuvanted plasmid DNA vaccines encoding influenza A virus H5 hemagglutinin

(2010) Larry R. Smith et al.   VACCINE

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Seasonal influenza vaccines: evolutions and future trends

(2009) Arnold S Monto et al.   Expert Review of Vaccines

Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments

(2009) Michael Schotsaert et al.   Expert Review of Vaccines

Prevention of infectious diseases in older adults through immunization: the challenge of the senescent immune response

(2009) Janet E McElhaney   Expert Review of Vaccines

Animal models for the preclinical evaluation of candidate influenza vaccines

(2009) Rogier Bodewes et al.   Expert Review of Vaccines

Climate change and infectious diseases in Europe

(2009) Jan C Semenza et al.   LANCET INFECTIOUS DISEASES

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population

(2009) J. A. Greenbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels

(2009) G. Galli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults

(2009) Janet E. McElhaney et al.   VACCINE

Comparative immunogenicity evaluations of influenza A virus M2 peptide as recombinant virus like particle or conjugate vaccines in mice and monkeys

(2009) Tong-Ming Fu et al.   VACCINE

DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial

(2009) Suzanne Jones et al.   VACCINE

A practical influenza neutralization assay to simultaneously quantify hemagglutinin and neuraminidase-inhibiting antibody responses

(2009) Arash Hassantoufighi et al.   VACCINE

A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects

(2009) Thomas R. Cate et al.   VACCINE

Characterization of antibodies against ferret immunoglobulins, cytokines and CD markers

(2009) Cyril Jean-Marie Martel et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Pathology, Molecular Biology, and Pathogenesis of Avian Influenza A (H5N1) Infection in Humans

(2008) Christine Korteweg et al.   AMERICAN JOURNAL OF PATHOLOGY

Climate and Vectorborne Diseases

(2008) Kenneth L. Gage et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Correlation of Cellular Immune Responses with Protection against Culture-Confirmed Influenza Virus in Young Children

(2008) B. D. Forrest et al.   Clinical and Vaccine Immunology

Vaccines: Correlates of Vaccine‐Induced Immunity

(2008) Stanley A. Plotkin   CLINICAL INFECTIOUS DISEASES

Cloning, expression and immunoassay detection of ferret IFN-γ

(2008) Atsuo Ochi et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Animal models in influenza vaccine testing

(2008) Jan Willem van der Laan et al.   Expert Review of Vaccines

Screening monoclonal antibodies for cross-reactivity in the ferret model of influenza infection

(2008) John A. Rutigliano et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY

Update on Avian Influenza A (H5N1) Virus Infection in Humans

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

Sublingual vaccination with influenza virus protects mice against lethal viral infection

(2008) J.-H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FDA/NIH/WHO public workshop on immune correlates of protection against influenza A viruses in support of pandemic vaccine development, Bethesda, Maryland, US, December 10–11, 2007

(2008) Maryna Eichelberger et al.   VACCINE

Correlates of protection: Novel generations of influenza vaccines

(2008) Guus F. Rimmelzwaan et al.   VACCINE

Efficacy of live attenuated influenza vaccine in children: A meta-analysis of nine randomized clinical trials

(2008) Janelle Rhorer et al.   VACCINE

Efficient induction of mucosal and systemic immune responses by virus-like particles administered intranasally: implications for vaccine design

(2007) Juliana Bessa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY