Challenges of assessing the clinical efficacy of asexual blood-stagePlasmodium falciparummalaria vaccines

Taking a Bite out of Malaria: Controlled Human Malaria Infection by Needle and Syringe

(2013) Judith E. Epstein   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Comparison of Modeling Methods to Determine Liver-to-blood Inocula and Parasite Multiplication Rates During Controlled Human Malaria Infection

(2013) Alexander D. Douglas et al.   JOURNAL OF INFECTIOUS DISEASES

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity

(2013) E. M. Bijker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled Human Blood Stage Malaria Infection: Current Status and Potential Applications

(2012) Christopher J. A. Duncan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Real-Time Quantitative Reverse Transcription PCR for Monitoring of Blood-Stage Plasmodium falciparum Infections in Malaria Human Challenge Trials

(2012) Sean C. Murphy et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Controlled Human Malaria Infections by Intradermal Injection of Cryopreserved Plasmodium falciparum Sporozoites

(2012) Meta Roestenberg et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Identification of a Potent Combination of Key Plasmodium falciparum Merozoite Antigens That Elicit Strain-Transcending Parasite-Neutralizing Antibodies

(2012) Alok K. Pandey et al.   INFECTION AND IMMUNITY

Recombinant Viral-Vectored Vaccines Expressing Plasmodium chabaudi AS Apical Membrane Antigen 1: Mechanisms of Vaccine-Induced Blood-Stage Protection

(2012) S. Biswas et al.   JOURNAL OF IMMUNOLOGY

Efficacy of Preerythrocytic and Blood-Stage Malaria Vaccines Can Be Assessed in Small Sporozoite Challenge Trials in Human Volunteers

(2012) M. Roestenberg et al.   JOURNAL OF INFECTIOUS DISEASES

Global malaria mortality between 1980 and 2010: a systematic analysis

(2012) Christopher JL Murray et al.   LANCET

Human microbial challenge: the ultimate animal model

(2012) Andrew J Pollard et al.   LANCET INFECTIOUS DISEASES

ChAd63-MVA–vectored Blood-stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy Against Mosquito Bite Challenge in Humans

(2012) Susanne H Sheehy et al.   MOLECULAR THERAPY

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

(2012) Magnus Manske et al.   NATURE

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of Clinical and Parasitological Data from Controlled Human Malaria Infection Trials

(2012) Meta Roestenberg et al.   PLoS One

Efficient Measurement of Opsonising Antibodies to Plasmodium falciparum Merozoites

(2012) Danika L. Hill et al.   PLoS One

Experimentally induced blood stage malaria infection as a tool for clinical research

(2012) Christian R. Engwerda et al.   TRENDS IN PARASITOLOGY

A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines

(2012) Matthew B. Laurens et al.   VACCINE

Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy?

(2012) Christopher J.A. Duncan et al.   Human Vaccines & Immunotherapeutics

Induction of Strain-Transcending Antibodies Against Group A PfEMP1 Surface Antigens from Virulent Malaria Parasites

(2012) Ashfaq Ghumra et al.   PLoS Pathogens

The Role of Animal Models for Research on Severe Malaria

(2012) Alister G. Craig et al.   PLoS Pathogens

Blood stage vaccines forPlasmodium falciparum

(2011) Ruth D. Ellis et al.   Human vaccines & immunotherapeutics

Substantially Reduced Pre-patent Parasite Multiplication Rates Are Associated With Naturally Acquired Immunity to Plasmodium falciparum

(2011) A. D. Douglas et al.   JOURNAL OF INFECTIOUS DISEASES

Defying malaria: Arming T cells to halt malaria

(2011) Michael F Good et al.   NATURE MEDICINE

Protection against Malaria by MSP3 Candidate Vaccine

(2011) Sodiomon B. Sirima et al.   NEW ENGLAND JOURNAL OF MEDICINE

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

A Field Trial to Assess a Blood-Stage Malaria Vaccine

(2011) Mahamadou A. Thera et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccination with Plasmodium knowlesi AMA1 Formulated in the Novel Adjuvant Co-Vaccine HT™ Protects against Blood-Stage Challenge in Rhesus Macaques

(2011) Muzamil Mahdi Abdel Hamid et al.   PLoS One

Virosome-Formulated Plasmodium falciparum AMA-1 & CSP Derived Peptides as Malaria Vaccine: Randomized Phase 1b Trial in Semi-Immune Adults & Children

(2011) Patrick Georges Cech et al.   PLoS One

Impact on Malaria Parasite Multiplication Rates in Infected Volunteers of the Protein-in-Adjuvant Vaccine AMA1-C1/Alhydrogel+CPG 7909

(2011) Christopher J. A. Duncan et al.   PLoS One

Evidence for erythrocyte-binding antigen 175 as a component of a ligand-blocking blood-stage malaria vaccine

(2011) L. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenicity of the Tuberculosis Vaccine MVA85A Is Reduced by Coadministration with EPI Vaccines in a Randomized Controlled Trial in Gambian Infants

(2011) M. O. C. Ota et al.   Science Translational Medicine

Harnessing immune responses against Plasmodium for rational vaccine design

(2011) Bruno Douradinha et al.   TRENDS IN PARASITOLOGY

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

(2011) Alexander D. Douglas et al.   Nature Communications

Blood-stage malaria vaccines — recent progress and future challenges

(2010) A. L. Goodman et al.   ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY

An adaptable two-color flow cytometric assay to quantitate the invasion of erythrocytes by Plasmodium falciparum parasites

(2010) Michel Theron et al.   CYTOMETRY PART A

Whole parasite blood stage malaria vaccines: A convergence of evidence

(2010) James S McCarthy et al.   Human vaccines & immunotherapeutics

Reticulocyte and Erythrocyte Binding-Like Proteins Function Cooperatively in Invasion of Human Erythrocytes by Malaria Parasites

(2010) Sash Lopaticki et al.   INFECTION AND IMMUNITY

Advances and challenges in malaria vaccine development

(2010) Peter D. Crompton et al.   JOURNAL OF CLINICAL INVESTIGATION

Malaria elimination: worthy, challenging, and just possible

(2010) Pam Das et al.   LANCET

Clinical Protection from Falciparum Malaria Correlates with Neutrophil Respiratory Bursts Induced by Merozoites Opsonized with Human Serum Antibodies

(2010) Charlotte Joos et al.   PLoS One

Age-Patterns of Malaria Vary with Severity, Transmission Intensity and Seasonality in Sub-Saharan Africa: A Systematic Review and Pooled Analysis

(2010) Ilona Carneiro et al.   PLoS One

The Relationship between Anti-merozoite Antibodies and Incidence of Plasmodium falciparum Malaria: A Systematic Review and Meta-analysis

(2010) Freya J. I. Fowkes et al.   PLOS MEDICINE

Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1 Induce Antibody- and T Cell-Mediated Multistage Protection against Malaria

(2009) Simon J. Draper et al.   Cell Host & Microbe

Anti-Apical-Membrane-Antigen-1 Antibody Is More Effective than Anti-42-Kilodalton-Merozoite-Surface-Protein-1 Antibody in Inhibiting Plasmodium falciparum Growth, as Determined by the In Vitro Growth Inhibition Assay

(2009) K. Miura et al.   Clinical and Vaccine Immunology

The Potential Role of Vaccines in the Elimination of Falciparum Malaria and the Eventual Eradication of Malaria

(2009) Christopher V. Plowe et al.   JOURNAL OF INFECTIOUS DISEASES

Randomized, Double‐Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria‐Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

(2009) Kent E. Kester et al.   JOURNAL OF INFECTIOUS DISEASES

Adjuvants for malaria vaccines

(2009) R. N. COLER et al.   PARASITE IMMUNOLOGY

Do we still need a malaria vaccine?

(2009) B. GREENWOOD et al.   PARASITE IMMUNOLOGY

Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A

(2009) Michele D. Spring et al.   PLoS One

High Antibody Titer against Apical Membrane Antigen-1 Is Required to Protect against Malaria in the Aotus Model

(2009) Sheetij Dutta et al.   PLoS One

Extreme Polymorphism in a Vaccine Antigen and Risk of Clinical Malaria: Implications for Vaccine Development

(2009) S. L. Takala et al.   Science Translational Medicine

Vaccinating with the genome: a Sisyphean task?

(2009) Ross L. Coppel   TRENDS IN PARASITOLOGY

Report of a Consultation on the Optimization of Clinical Challenge Trials for Evaluation of Candidate Blood Stage Malaria Vaccines, 18–19 March 2009, Bethesda, MD, USA

(2009) V.S. Moorthy et al.   VACCINE

Malaria vaccines: the case for a whole-organism approach

(2008) Alberto Pinzon-Charry et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies

(2008) Kristina E.M. Persson et al.   JOURNAL OF CLINICAL INVESTIGATION

Changes in malaria indices between 1999 and 2007 in The Gambia: a retrospective analysis

(2008) Serign J Ceesay et al.   LANCET

Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya

(2008) Wendy P O'Meara et al.   LANCET

Immunity to malaria: more questions than answers

(2008) Jean Langhorne et al.   NATURE IMMUNOLOGY

Evidence of Blood Stage Efficacy with a Virosomal Malaria Vaccine in a Phase IIa Clinical Trial

(2008) Fiona M. Thompson et al.   PLoS One

Protection Induced by Plasmodium falciparum MSP142 Is Strain-Specific, Antigen and Adjuvant Dependent, and Correlates with Antibody Responses

(2008) Jeffrey A. Lyon et al.   PLoS One