Article
Multidisciplinary Sciences
Rina Kim, Ayumi Hashimoto, Nune Markosyan, Vladimir A. Tyurin, Yulia Y. Tyurina, Gozde Kar, Shuyu Fu, Mohit Sehgal, Laura Garcia-Gerique, Andrew Kossenkov, Bereket A. Gebregziabher, John W. Tobias, Kristin Hicks, Rebecca A. Halpin, Nevena Cvetesic, Hui Deng, Laxminarasimha Donthireddy, Andrew Greenberg, Brian Nam, Robert H. Vonderheide, Yulia Nefedova, Valerian E. Kagan, Dmitry Gabrilovich
Summary: Ferroptosis is a unique and targetable immunosuppressive mechanism in the tumor microenvironment, which can be pharmacologically modulated to limit tumor progression. It induces spontaneous death of PMN-MDSCs in the tumor microenvironment and limits the activity of human and mouse T cells.
Article
Agriculture, Dairy & Animal Science
Qingtao Gao, Feng Zhao, Ya Wang, Hu Zhang, Jiangtao Zhao, Lixiang Gao, Xuelan Liu, Yuming Wang
Summary: The objective of this study was to predict the apparent total tract digestibility (ATTD) of energy in cereals and byproducts for growing pigs using an in vitro digestion procedure. It was found that the in vitro digestible energy (IVDE) determined with the computer-controlled simulated digestion system (CCSDS) can accurately predict the digestible energy (DE) and metabolizable energy (ME) of cereals and byproducts. Additionally, excluding certain ingredients improved the accuracy of the prediction model when considering the leverage effect.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Zhongyuan Du, Yuming Wang, Mingqiang Song, Shuli Zeng, Lixiang Gao, Jiangtao Zhao, Feng Zhao
Summary: The objective of this experiment was to develop a new computer-controlled simulated digestion system to predict the digestible energy and metabolizable energy of unconventional plant protein meals. The results showed that in vitro digestible energy had a good prediction effect on digestible energy but a poor prediction effect on metabolizable energy.
Article
Biochemistry & Molecular Biology
Pedro F. Almaida-Pagan, Alejandro Lucas-Sanchez, Antonio Martinez-Nicolas, Eva Terzibasi, Maria Angeles Rol de Lama, Alessandro Cellerino, Pilar Mendiola, Jorge de Costa
Summary: This study investigated the lipid composition of cell membranes in two species of the Amphiprion genus and one species of damselfish to test the Longevity-Homeoviscous Adaptation (LHA) theory of ageing, revealing a negative correlation between membrane peroxidation index and maximum lifespan in the Amphiprion species. However, when compared to the shorter-lived damselfish, contradictory data were obtained, indicating that the differences in membrane lipid composition alone cannot explain the diversity in longevity found among fishes.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Chemistry, Applied
Qian Liu, Junying Zhao, Yan Liu, Weicang Qiao, Tiemin Jiang, Yan Liu, Xiaowen Yu, Lijun Chen
Summary: The differences in composition and distribution of fatty acids make human milk lipids distinct from those of other mammals. Understanding the concentrations, compositions, and distribution characteristics of milk lipids requires analysis and detection technology. The characteristics and mimicking of human milk lipids have been extensively studied to reduce the gap between human milk and infant formulae.
Article
Chemistry, Applied
Shiyi Lu, Jie Li, Jingyun Ji, Yangyang Wen, Hongyan Li, Jing Wang, Baoguo Sun
Summary: This study investigates the effects of endogenous proteins and lipids on starch digestibility in quinoa flour and explores the physicochemical and textural properties related to the digestion process. Cooked whole quinoa flours have the highest starch digestibility, while pure quinoa starch has the lowest digestibility. Gel network is identified as a primary factor affecting the digestion process of starch in different quinoa flours.
FOOD HYDROCOLLOIDS
(2023)
Article
Engineering, Environmental
Yuanyuan Ren, Chen Wang, Ziang He, Yemei Li, Yu Qin, Yu-You Li
Summary: High-solid anaerobic co-digestion of lipids and food waste at different lipid/TS ratios was studied under thermophilic and mesophilic conditions with a HRT of 30 days. The results showed that the organic loading rate of lipids achieved 2.33 g/L/d and 1.67 g/L/d, and the degradation efficiency of lipids reached 87% and 85% in the thermophilic and mesophilic systems, respectively. The methane content in the biogas increased significantly as the lipid/TS ratio increased, and the average methane yield was 288 mL-CH4/g-COD and 275 mL-CH4/g-COD for thermophilic and mesophilic co-digestion, respectively. The energy surplus of mesophilic co-digestion was 9% higher than that of thermophilic co-digestion when the lipid/TS ratio was below 50%.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Food Science & Technology
Alba Tamargo, Dolores Gonzalez de Llano, Carolina Cueva, Joaquin Navarro del Hierro, Diana Martin, Natalia Molinero, Begona Bartolome, M. Victoria Moreno-Arribas
Summary: This study investigates the interactions between lipids and red wine polyphenols in the gastrointestinal tract. The results show that co-digestion with lipids slightly affects the phenolic profile of red wine polyphenols. The co-digestion tends to increase the bioaccessible monoglycerides and reduce cholesterol bioaccessibility.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Yihong Chen, Hazel Rooney, Cathal Dold, Simona Bavaro, John Tobin, Michael J. Callanan, Andre Brodkorb, Peadar G. Lawlor, Linda Giblin
Summary: Membrane filtration can produce infant milk formula that is more similar to breast milk. Compared to traditionally heat-treated formula, membrane-filtered formula has a higher content of native whey protein. In vivo evidence shows that membrane-filtered formula influences protein digestion but has minimal effects on overall growth parameters.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Yi Shen, Wanxin Gong, Yu Li, Jiaming Deng, Xiaoli Shu, Dianxing Wu, Nicoletta Pellegrini, Ning Zhang
Summary: The study found that accelerated ageing treatment significantly reduced NSL and gamma-oryzanol in ALK3 and RS4 mutants, as well as decreased the pH of cooking solution and the Tp of the second endothermic peak in DSC, indicating lipid hydrolysis and damage to the amylose-lipids complex. Additionally, all varieties had lower proportion of unsaturated fatty acids in lipids and lower breakdown, suggesting inferior lipid quality and rice eating and cooking quality after ageing treatment. However, high-lipid mutants showed better nutritional quality with higher gamma-oryzanol content and lower initial digestion rate even after storage.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Environmental
Nur Hazimah Mohamed Nor, Zhiyue Niu, Marie Hennebelle, Albert A. Koelmans
Summary: Using an in vitro gut fluid digestive model, researchers assessed the effect of digestive processes on chemical exchange kinetics on microplastics. Results showed that the digestive processes can increase chemical concentration on microplastics by a factor of 10-20, thereby reducing overall chemical bioavailability. These findings are important for assessing the risks of microplastics to human health and biomagnification in aquatic food webs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Agricultural Engineering
Haiquan Dong, Liangchen Yue, Jun Cheng, Rongxin Xia, Junhu Zhou
Summary: Microbial electro-chemical degradation was proposed to enhance methane production from lipids in anaerobic digestion. Applying a voltage strengthened the beta-oxidation of lipids, promoting electron transfer and methane yield. The overall energy conversion efficiency in methane production increased due to microbial electrochemical degradation of lipids.
BIORESOURCE TECHNOLOGY
(2022)
Article
Chemistry, Applied
B. Miralles, J. Sanchon, L. Sanchez-Rivera, D. Martinez-Maqueda, Y. Le Gouar, D. Dupont, L. Amigo, I. Recio
Summary: Correlation and validation between simulated and in vivo gastrointestinal digestion of food compounds is crucial. This study monitored the digestion of milk micellar casein in the porcine upper intestinal tract and found clear similarities between in vitro and in vivo generated peptide profiles, with the in vitro digestion model providing a similar peptide profile to that found in the porcine duodenum.
Article
Multidisciplinary Sciences
Katalin Nagy, Hedvig Febel, George Bazar, Gyorgy Grosz, Robert Gaspar, Kalman Ferenc Szucs, Tamas Toth
Summary: The study adapted SMEMG methodology from laboratory rats to pigs to investigate the effects of feedstuffs with different fiber contents on gastrointestinal tract motility. The results showed a significant increase in PsDmax values of the small intestine with the EXP diet, while no significant changes were observed in the stomach and large intestine. SMEMG is a suitable direct and non-invasive method for rapid evaluation of the effects of diets with different fiber contents on the GIT of non-anaesthetised, free-moving pigs.
Article
Environmental Sciences
Adi Kusmayadi, Po-Han Lu, Chi-Yu Huang, Yoong Kit Leong, Hong-Wei Yen, Jo-Shu Chang
Summary: This study demonstrated the use of different strategies for treating dairy wastewaters with varying COD levels, showing that microalgal cultivation can achieve high biomass concentration and efficient removal of COD while recovering nutrients.
Review
Infectious Diseases
Gerald C. Shurson, Pedro E. Urriola, Jennifer L. G. van de Ligt
Summary: Prions and pathogens pose significant threats to food safety, but risk can be reduced through thermal processing and quality control. Global outbreaks of swine viruses highlight the urgent need for rigorous biosecurity measures in feed ingredients to minimize safety and sustainability risks.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Infectious Diseases
Gerald C. Shurson, Amanda Palowski, Jennifer L. G. van de Ligt, Declan C. Schroeder, Cecilia Balestreri, Pedro E. Urriola, Fernando Sampedro
Summary: There is no published evidence of African swine fever virus in feed ingredients or complete feed, likely due to limitations in detection technology, data availability, and challenges. Some feed matrices were found to support virus survival longer than others in experiments, but the reasons are still unknown.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Agronomy
Senait D. Senay, Gerald C. Shurson, Carol Cardona, Kevin A. T. Silverstein
Summary: One of the major challenges in global food security is the ever-changing biotic risks affecting food supply systems. Strategies to minimize these risks depend heavily on research on plant and animal diseases, with epidemiological models becoming more accurate with high-resolution data. However, challenges such as data privacy concerns limit researchers' access to comprehensive data on pathogens and their environments.
Article
Infectious Diseases
Rachel A. Schambow, Fernando Sampedro, Pedro E. Urriola, Jennifer L. G. van de Ligt, Andres Perez, Gerald C. Shurson
Summary: A quantitative risk assessment model was developed to estimate the probability of ASFV-contaminated corn or soybean meal ocean vessels being imported into the United States annually. The model considered different likelihood conditions and found that recontamination had a significant impact on the risk of ASFV-contaminated soybean meal vessels entering the United States.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Multidisciplinary Sciences
Zhengxia Dou, John D. Toth, Dipti W. Pitta, Joseph S. Bender, Meagan L. Hennessy, Bonnie Vecchiarelli, Nagaraju Indugu, Ting Chen, Yunyun Li, Rachel Sherman, Jonathan Deutsch, Bo Hu, Gerald C. Shurson, Brianna Parsons, Linda D. Baker
Summary: This study aims to develop novel feeds for cattle from crop-based biomass through ensiling processes. The findings show that the (co-)ensiled products have comparable nutritional parameters to good quality forages commonly used on dairy farms, and can substitute certain conventional feeds while maintaining digestibility. This pilot study provides a proof of principle for generating quality novel feeds for cattle by co-ensiling food discards and low-value crop residues.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Tai Hung, Yajian Song, Qiong Hu, Richard J. Faris, Juanjuan Guo, Yiwei Ma, Milena Saqui-Salces, Pedro E. Urriola, Gerald C. Shurson, Chi Chen
Summary: Feeding high-fiber coproducts to grow-finish pigs can compromise their growth performance, while the inclusion of antibiotic growth promoters may improve it. The metabolic interactions between fiber and antibiotics in the digestive tract of pigs and their detectability in feces have not been well-examined. In this study, metabolomic analysis showed comprehensive metabolic changes in pigs fed with high-fiber coproducts, while selective metabolic changes were observed with the inclusion of antibiotics. Limited metabolic interactions were found between fiber and antibiotics treatment. Fecal metabolome can be used as a source of biomarkers to monitor and predict the metabolic performance of grow-finish pigs.
Article
Biochemistry & Molecular Biology
Yue Guo, Lei Wang, Andrea Hanson, Pedro E. Urriola, Gerald C. Shurson, Chi Chen
Summary: Feeding pigs oxidized lipids has negative effects on growth and health, but the impact on amino acid metabolism has not been well studied. This research found that feeding oxidized corn oil to nursery pigs caused changes in amino acid homeostasis and metabolic pathways. These changes, including increased antioxidant responses, suggest that pigs are capable of adapting to the consumption of oxidized lipids by adjusting amino acid metabolism.
Article
Agriculture, Dairy & Animal Science
Jinlong Zhu, Gerald C. Shurson, Lynsey Whitacre, Ignacio R. Ipharraguerre, Pedro E. Urriola
Summary: The objective of this study was to determine the effects of Aspergillus oryzae prebiotic (AOP) on nutrient digestibility in growing pigs fed high-fiber diets. The results showed that supplementation of AOP increased the nutrient and energy digestibility value in high-fiber diets containing DDGS, RB, or WM.
TRANSLATIONAL ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Zhaohui Yang, Pedro E. Urriola, Lee J. Johnston, Gerald C. Shurson
Summary: Traditionally, swine diets focused on meeting nutrient requirements at the lowest cost, without considering the environmental impact. This study aimed to compare the effects of four different grower-finisher feeding programs on growth performance, carcass composition, nitrogen utilization efficiency, and environmental impacts. The results showed that feeding diets containing corn and soybean meal (CSBM) led to better growth performance, carcass composition, and reduced environmental impacts compared to diets with lower protein content or distillers dried grains with solubles (DDGS) supplementation.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Michaela Trudeau, Wes Mosher, Huyen Tran, Brenda C. de Rodas, Theodore H. Karnezos, Pedro H. Urriola, Andres H. Gomez, Milena Saqui-Salces, Chi Chen, Gerald Shurson
Summary: The objective of this study was to analyze the changes in the intestinal metabolome and microbiome of weaned pigs fed subtherapeutic concentrations of antibiotics. Three experiments with the same antibiotic treatments were conducted on a research farm, revealing that facility had a greater effect on growth performance, metabolome, and microbiome responses than feeding diets containing antibiotics. Serum metabolome and ileal and cecal microbiome beta diversity differed between experiments, but there were no differences in microbiome alpha diversity.
Article
Agriculture, Dairy & Animal Science
Anna S. Clarke, Chris Faulk, Gerald C. Shurson, Daniel D. Gallaher, Lee J. Johnston
Summary: This study aimed to evaluate the effectiveness of feeding beta-hydroxy-beta-methylbutyrate (HMB) to pregnant mice in improving birth weight uniformity and growth performance of offspring. The results showed that dietary HMB supplementation in pregnant mice did not affect birth weight, variations in birth weight, or growth performance of offspring.
Review
Agriculture, Dairy & Animal Science
Gerald C. Shurson, Pedro E. Urriola, Declan C. Schroeder
Summary: Global trade of feed ingredients contaminated with swine viruses raises concerns about disease transmission. Biosecurity protocols and measures are needed to prevent virus contamination, along with the development of accurate analytical methods for detecting viable virus concentrations. Effective decontamination strategies and the use of antiviral ingredients are also important. Current lack of standardized procedures and systems for measuring virus contamination in feed supply chains contributes to high uncertainty.
Article
Biochemistry & Molecular Biology
Junwei Zhang, Pedro E. Urriola, Seth L. Naeve, Gerald C. Shurson, Chi Chen
Summary: This study examined the protein oxidation of solvent extracted soybean meal (SSBM) and mechanically extracted soybean meal (MSBM) from different sources and found that extraction methods and non-protein components can affect the degree of protein oxidation. Positive correlations were observed between protein carbonyl content and lipid parameters, while negative correlations were found with certain antioxidants. These findings provide reference values for evaluating the protein quality of soybean meal from different sources.
Article
Agriculture, Dairy & Animal Science
Vinicius Ricardo Cambito de Paula, Natalia Cristina Milani, Candida Pollyanna Francisco Azevedo, Anderson Aparecido Sedano, Leury Jesus de Souza, Gerald Carlyle Shurson, Urbano dos Santos Ruiz
Summary: The objective of this study was to determine and compare the chemical composition, oxidation indicators, ether extract digestibility, and energy content of distillers corn oil (DCO) from Brazil and the United States, along with refined and degummed soybean oil from Brazil, offered to pigs. The results showed that DCO produced in Brazil is an excellent energy source for pigs, with similar energy characteristics to DCO from the US and soybean oils.
REVISTA BRASILEIRA DE ZOOTECNIA-BRAZILIAN JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Brigit M. Lozinski, Brent Frederick, Yuzhi Li, Milena Saqui-Salces, Gerald C. Shurson, Pedro E. Urriola, Melissa L. Wilson, Lee J. Johnston
Summary: An experiment was conducted to determine the effects of providing drinking water of differing qualities on growth performance and health of nursery pigs. The results showed that different qualities of water did not have a significant impact on the growth and health of nursery pigs.
TRANSLATIONAL ANIMAL SCIENCE
(2022)