Molecularly and clinically related drugs and diseases are enriched in phenotypically similar drug-disease pairs

Treatment of Psychosis and Dementia in Parkinson’s Disease

(2014) Jennifer G. Goldman et al.   Current Treatment Options in Neurology

Suspect Drug Research Blamed for Massive Death Toll

(2014) G. Vogel   SCIENCE

Mouse model phenotypes provide information about human drug targets

(2013) Robert Hoehndorf et al.   BIOINFORMATICS

A Nondegenerate Code of Deleterious Variants in Mendelian Loci Contributes to Complex Disease Risk

(2013) David R. Blair et al.   CELL

How to treat Parkinson's disease in 2013

(2013) P. F. Worth   CLINICAL MEDICINE

Second Generation Antipsychotic-Induced Type 2 Diabetes: A Role for the Muscarinic M3 Receptor

(2013) Katrina Weston-Green et al.   CNS DRUGS

Rational drug repositioning by medical genetics

(2013) Zhong-Yi Wang et al.   NATURE BIOTECHNOLOGY

Therapeutic potential of GABAB receptor ligands in drug addiction, anxiety, depression and other CNS disorders

(2013) Kushal Kumar et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Global Analysis of the Human Pathophenotypic Similarity Gene Network Merges Disease Module Components

(2013) Armando Reyes-Palomares et al.   PLoS One

Metabolic Side-Effects of the Novel Second-Generation Antipsychotic Drugs Asenapine and Iloperidone: A Comparison with Olanzapine

(2013) Heidi N. Boyda et al.   PLoS One

Parkinson's disease in the nuclear age of neuroinflammation

(2013) Yvonne M. Nolan et al.   TRENDS IN MOLECULAR MEDICINE

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Purines, Purinergic Receptors, and Cancer

(2012) F. Di Virgilio   CANCER RESEARCH

Prefrontal dopaminergic receptor abnormalities and executive functions in Parkinson's disease

(2012) Ji Hyun Ko et al.   HUMAN BRAIN MAPPING

Exploiting drug-disease relationships for computational drug repositioning

(2011) J. T. Dudley et al.   BRIEFINGS IN BIOINFORMATICS

Stress, anxiety and depression: Toward new treatment strategies

(2011) Athina Markou et al.   NEUROPHARMACOLOGY

STITCH 3: zooming in on protein-chemical interactions

(2011) M. Kuhn et al.   NUCLEIC ACIDS RESEARCH

A Gene-Phenotype Network for the Laboratory Mouse and Its Implications for Systematic Phenotyping

(2011) Octavio Espinosa et al.   PLoS One

Gene-Disease Network Analysis Reveals Functional Modules in Mendelian, Complex and Environmental Diseases

(2011) Anna Bauer-Mehren et al.   PLoS One

Network Neighbors of Drug Targets Contribute to Drug Side-Effect Similarity

(2011) Lucas Brouwers et al.   PLoS One

Thyroid hormone metabolism in skeletal development and adult bone maintenance

(2011) Julian A. Waung et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Prasugrel as a Potential Cancer Promoter: Review of the Unpublished Data

(2010) James S. Floyd   ARCHIVES OF INTERNAL MEDICINE

DisGeNET: a Cytoscape plugin to visualize, integrate, search and analyze gene–disease networks

(2010) Anna Bauer-Mehren et al.   BIOINFORMATICS

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Second-Generation Antipsychotic Drugs and Extrapyramidal Side Effects: A Systematic Review and Meta-analysis of Head-to-Head Comparisons

(2010) Christine Rummel-Kluge et al.   SCHIZOPHRENIA BULLETIN

Integrating phenotype ontologies across multiple species

(2010) Christopher J Mungall et al.   GENOME BIOLOGY

A Gut Feeling about GABA: Focus on GABAB Receptors

(2010) Niall P. Hyland et al.   Frontiers in Pharmacology

Rewriting and suppressing UMLS terms for improved biomedical term identification

(2010) Kristina M Hettne et al.   Journal of Biomedical Semantics

Quetiapine in the treatment of psychosis in Parkinson’s disease

(2010) Paul Shotbolt et al.   Therapeutic Advances in Neurological Disorders

The Expanded Biology of Serotonin

(2009) Miles Berger et al.   Annual Review of Medicine

Drug-induced parkinsonism

(2009) Frandy Susatia et al.   Current Treatment Options in Neurology

STITCH 2: an interaction network database for small molecules and proteins

(2009) Michael Kuhn et al.   NUCLEIC ACIDS RESEARCH

Linking Human Diseases to Animal Models Using Ontology-Based Phenotype Annotation

(2009) Nicole L. Washington et al.   PLOS BIOLOGY

Semantic Similarity in Biomedical Ontologies

(2009) Catia Pesquita et al.   PLoS Computational Biology

A Dynamic Network Approach for the Study of Human Phenotypes

(2009) César A. Hidalgo et al.   PLoS Computational Biology

Family based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3)

(2008) Eric Mick et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Fibrinolysis: The Key to New Pathogenetic Mechanisms

(2008) Esther Zorio et al.   CURRENT MEDICINAL CHEMISTRY

Fast unfolding of communities in large networks

(2008) Vincent D Blondel et al.   JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT

Dasatinib-induced lupus

(2008) Delphine Rea et al.   LANCET

The genetics of bipolar disorder: genome ‘hot regions,’ genes, new potential candidates and future directions

(2008) A Serretti et al.   MOLECULAR PSYCHIATRY

Data completeness—the Achilles heel of drug-target networks

(2008) Jordi Mestres et al.   NATURE BIOTECHNOLOGY

Differential Effects of Various Typical and Atypical Antipsychotics on Plasma Glucose and Insulin Levels in the Mouse: Evidence for the Involvement of Sympathetic Regulation

(2008) Y. E. Savoy et al.   SCHIZOPHRENIA BULLETIN

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE

Response to methylphenidate in adults with ADHD is associated with a polymorphism inSLC6A3 (DAT1)

(2007) J. Sandra Kooij et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS