Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 110, Issue -, Pages 174-184Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2013.07.003
Keywords
GABA; Anxiety; Addiction; Depression; Neurodegenerative disorders; CNS disorders
Funding
- ISF College of Pharmacy, Moga (Punjab)
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Glutamate and gamma-aminobutyric acid (GABA) are the major excitatory and inhibitory neurotransmitter systems, respectively in the central nervous system (CNS). Dysregulation, in any of these or both, has been implicated in various CNS disorders. GABA acts via ionotropic (GABA(A) and GABA(C) receptor) and metabotropic (GABA(B)) receptor. Dysregulation of GABAergic signaling and alteration in GABA(B) receptor expression has been implicated in various CNS disorders. Clinically, baclofen-a GABA(B) receptor agonist is available for the treatment of spasticity, dystonia etc., associated with various neurological disorders. Moreover, GABA(B) receptor ligands has also been suggested to be beneficial in various neuropsychiatric and neurodegenerafive disorders. The present review is aimed to discuss the role of GABA(B) receptors and the possible outcomes of GABA(B) receptor modulation in CNS disorders. (C) 2013 Elsevier Inc. All rights reserved.
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