Article
Cardiac & Cardiovascular Systems
Arlana G. Taylor, Andrew I. Ignaszewski, Shannon S. D. Bredin, John S. Hill, Erin M. Shellington, Darren E. R. Warburton
Summary: This study aimed to evaluate the acute inflammatory response in patients with chronic heart failure (CHF) following steady state (SS) or high intensity interval training (HIIT). The results showed that a single bout of HIIT or SS did not result in excessive inflammatory activation in CHF patients, and both types of exercise had similar effects on inflammatory markers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ambarish Pandey, Matthew W. Segar, Sumitabh Singh, Gordon Reeves, Christopher O'Connor, Ileana Pina, David Whellan, William Kraus, Robert Mentz, Dalane Kitzman
Summary: This study investigates the impact of baseline frailty on the efficacy of aerobic exercise training in patients with heart failure. The results show that aerobic exercise training significantly reduces the risk of all-cause hospitalization in frail patients, but the effect is not significant for non-frail patients.
Article
Medicine, General & Internal
Maurizio Volterrani, Giuseppe Caminiti, Marco Alfonso Perrone, Anna Cerrito, Alessio Franchini, Vincenzo Manzi, Ferdinando Iellamo
Summary: The effectiveness of concurrent exercise training program in patients with chronic heart failure was evaluated. The study showed that concurrent training resulted in significant improvements in functional capacity and muscular strength, compared to single-mode aerobic training, without major side effects.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Vandana Sachdev, Kavita Sharma, Steven J. Keteyian, Charina F. Alcain, Patrice Desvigne-Nickens, Jerome L. Fleg, Viorel G. Florea, Barry A. Franklin, Maya Guglin, Martin Halle, Eric S. Leifer, Gurusher Panjrath, Emily A. Tinsley, Renee P. Wong, Dalane W. Kitzman
Summary: HFpEF is a common form of heart failure with increasing prevalence and worsening outcomes. Pharmacological interventions have shown limited efficacy, while exercise-based interventions consistently improve symptoms and quality of life. This may be attributed to the pleiotropic effects of exercise, which positively influence the various abnormalities contributing to exercise intolerance in HFpEF. This article critically examines the effects of exercise-based therapies, compares them with other cardiovascular conditions, and highlights gaps in implementation for future research.
Article
Medicine, Research & Experimental
Giuseppe Potrick Stefani, Lucas Capalonga, Lucas Ribeiro da Silva, Thiago Gomes Heck, Matias Nunes Frizzo, Lucas Machado Sulzbacher, Maicon Machado Sulzbacher, Diovana de Batista, Samlai Vedovatto, Ana Paula Santin Bertoni, Marcia Rosangela Wink, Pedro Dal Lago
Summary: The study found that combined exercise training (CET) with 13-alanine and L-histidine supplementation in rats with heart failure (HF) can improve functional capacity and biochemical variables, reduce oxidative stress and inflammation, and affect mRNA expression of calcium transporters in the skeletal muscle.
Article
Medicine, Research & Experimental
Chih-Chin Hsu, Jong-Shyan Wang, Yu-Chiau Shyu, Tieh-Cheng Fu, Yu-Hsiang Juan, Shin-Sheng Yuan, Chao-Hung Wang, Chi-Hsiao Yeh, Po-Cheng Liao, Hsin-Yi Wu, Pang-Hung Hsu
Summary: This translational research examined the implications of DNA methylation associated with high-intensity interval training (HIIT) on cardiac fibrosis in patients with heart failure (HF). The study found that HIIT can reduce cardiac fibrosis and improve cardiorespiratory fitness. This was confirmed through a variety of tests on HF patients, including cardiovascular magnetic resonance imaging and cardiopulmonary exercise tests, as well as cell experiments and proteomics analysis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Vandana Sachdev, Kavita Sharma, Steven J. Keteyian, Charina F. Alcain, Patrice Desvigne-Nickens, Jerome L. Fleg, Viorel G. Florea, Barry A. Franklin, Maya Guglin, Martin Halle, Eric S. Leifer, Gurusher Panjrath, Emily A. Tinsley, Renee P. Wong, Dalane W. Kitzman
Summary: HFpEF is a common form of heart failure with increasing prevalence and worsening outcomes. Exercise-based interventions have shown significant improvements in symptoms, exercise capacity, and quality of life. The pleiotropic effects of exercise may contribute to these improvements by addressing the various abnormalities that contribute to exercise intolerance in HFpEF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Peter H. Brubaker, Barbara J. Nicklas, Denise K. Houston, W. Gregory Hundley, Haiying Chen, Anthony J. A. Molina, W. Mary Lyles, Benjamin Nelson, Bharathi Upadhya, Russell Newland, Dalane W. Kitzman
Summary: This study aimed to investigate whether adding resistance training (RT) to combined caloric restriction (CR) and aerobic exercise training (AT) can reduce skeletal muscle loss and further improve outcomes in older obese heart failure patients. The results showed that adding RT to CR+AT increased leg muscle strength and quality, but did not reduce skeletal muscle and weight loss, or further increase VO2peak or quality-of-life.
CIRCULATION-HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Mattia Lunardi, Sijing Wu, Patrick W. Serruys, Yoshinobu Onuma, Osama Soliman, William Wijns, Wilfried Mullens, Faisal Sharif
Summary: More than half of heart failure patients also have pulmonary hypertension, which affects symptoms and prognosis. The role of exercise in this patient population is still unclear due to a lack of clear understanding of the relationship between exercise and changes in pulmonary artery pressure and symptoms. The limited evidence on this topic is contradictory and difficult to compare due to different exercise programs and assessment techniques. The different classes of heart failure further complicate the assessment of exercise effects on outcomes. Future studies using advanced technologies may provide more insights into the effects of exercise training in heart failure patients with pulmonary hypertension.
Review
Cardiac & Cardiovascular Systems
Heather L. Wheat, Savitri Fedson, Biykem Bozkurt, Richard A. Josephson
Summary: Exercise intolerance is common in heart failure patients, and cardiac rehabilitation has shown significant benefits in improving mortality and quality of life. However, the benefits of exercise therapy may vary depending on the underlying disease phenotype.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Review
Cardiac & Cardiovascular Systems
Ray W. Squires, Amanda R. Bonikowske
Summary: Heart transplantation is the preferred treatment for end-stage chronic heart failure. Although many patients experience improved functional ability after transplantation, they still face the challenges of acute rejection and other comorbidities. Exercise training, recommended before and after transplantation, can improve exercise capacity and skeletal muscle strength without altering immunosuppression.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Patricia F. Trevizan, Ligia M. Antunes-Correa, Denise M. L. Lobo, Patricia A. Oliveira, Dirceu R. de Almeida, Maria Cristina D. Abduch, Wilson Mathias Junior, Ludhmila Abrahao Hajjar, Roberto Kalil Filho, Carlos Eduardo Negrao
Summary: The study found that combined inspiratory muscle training and aerobic exercise training did not have more pronounced effects on neurovascular control in patients with heart failure with reduced ejection fraction compared to aerobic exercise training alone.
Article
Cardiac & Cardiovascular Systems
Ampadu O. Jackson, Jun Meng, Huifang Tang, Kai Yin
Summary: The prevalence of heart failure (HF) has significantly increased worldwide, with high-density lipoprotein (HDL) playing an important role in cardiac repair during HF. HDL may exert its effects in the progression of HF through multiple pathways such as regulation of excitation-contraction coupling, energy homeostasis, and inflammation.
HEART FAILURE REVIEWS
(2021)
Review
Medicine, General & Internal
Ran Guo, Yi Wen, Ying Xu, Ruikun Jia, Song Zou, Sijie Lu, Guobin Liu, Kaijun Cui
Summary: This study systematically reviewed the effects of exercise training in chronic heart failure patients with cardiac resynchronization therapy. The results indicated that in the short term, non-high intensity training could improve exercise capacity, cardiac function, and quality of life, with no significant statistical difference found in high intensity training.
Article
Cardiac & Cardiovascular Systems
Ioannis D. Laoutaris, Ewa Piotrowicz, Manolis S. Kallistratos, Athanasios Dritsas, Niki Dimaki, Dimitris Miliopoulos, Maria Andriopoulou, Athanasios J. Manolis, Maurizio Volterrani, Massimo F. Piepoli, Andrew J. S. Coats, Stamatis Adamopoulos
Summary: The ARISTOS-HF trial showed that exercise training for 180 min/week, particularly the ARIS training regime, is recommended for heart failure patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
T. Scott Bowen, Natale P. L. Rolim, Tina Fischer, Fredrik H. Baekkerud, Alessandra Medeiros, Sarah Werner, Eivind Bronstad, Oivind Rognmo, Norman Mangner, Axel Linke, Gerhard Schuler, Gustavo J. J. Silva, Ulrik Wisloff, Volker Adams
EUROPEAN JOURNAL OF HEART FAILURE
(2015)
Article
Physiology
T. Scott Bowen, Norman Mangner, Sarah Werner, Stefanie Glaser, Yvonne Kullnick, Andrea Schrepper, Torsten Doenst, Andreas Oberbach, Axel Linke, Leif Steil, Gerhard Schuler, Volker Adams
JOURNAL OF APPLIED PHYSIOLOGY
(2015)
Article
Physiology
Volker Adams, Marcia Alves, Tina Fischer, Natale Rolim, Sarah Werner, Nicole Schuett, T. Scott Bowen, Axel Linke, Gerhard Schuler, Ulrik Wisloff
JOURNAL OF APPLIED PHYSIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Martin Seiler, T. Scott Bowen, Natale Rolim, Maja-Theresa Dieterlen, Sarah Werner, Tomoya Hoshi, Tina Fischer, Norman Mangner, Axel Linke, Gerhard Schuler, Martin Halle, Ulrik Wisloff, Volker Adams
CIRCULATION-HEART FAILURE
(2016)
Editorial Material
Cardiac & Cardiovascular Systems
T. Scott Bowen, Sophia Eisenkolb, Sarah Werner, Michael Schwarzer, Gerhard Schuler, Volker Adams
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2016)
Article
Sport Sciences
Norman Mangner, T. Scott Bowen, Sarah Werner, Tina Fischer, Yvonne Kullnick, Andreas Oberbach, Axel Linke, Leif Steil, Gerhard Schuler, Volker Adams
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2016)
Article
Biochemistry & Molecular Biology
T. Scott Bowen, Sophia Eisenkolb, Juliane Drobner, Tina Fischer, Sarah Werner, Axel Linke, Norman Mangner, Gerhard Schuler, Volker Adams
Article
Geriatrics & Gerontology
Thomas Scott Bowen, Volker Adams, Sarah Werner, Tina Fischer, Paulien Vinke, Maria Noel Brogger, Norman Mangner, Axel Linke, Peter Sehr, Joe Lewis, Dittmar Labeit, Alexander Gasch, Siegfried Labeit
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2017)
Letter
Cardiac & Cardiovascular Systems
Petra Buettner, Sarah Werner, Philipp Sommer, Ralph Burkhardt, Samira Zeynalova, Ronny Baber, Andreas Bollmann, Daniela Husser-Bollmann, Joachim Thiery, Gerhard Hindricks, Holger Thiele, Jelena Kornej
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2019)
Article
Geriatrics & Gerontology
Volker Adams, T. Scott Bowen, Sarah Werner, Peggy Barthel, Christina Amberger, Anne Konzer, Johannes Graumann, Peter Sehr, Joe Lewis, Jan Provaznik, Vladimir Benes, Petra Buettner, Alexander Gasch, Norman Mangner, Christian C. Witt, Dittmar Labeit, Axel Linke, Siegfried Labeit
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2019)
Article
Biochemistry & Molecular Biology
Svetlana Baskal, Petra Buettner, Sarah Werner, Christian Besler, Philipp Lurz, Holger Thiele, Dimitrios Tsikas
Summary: HFpEF is associated with high mortality and limited therapeutic options, making it essential to explore underlying mechanisms and identify specific biomarkers. Obese ZSF1 rats serve as a valuable animal model for studying HFpEF progression. This study aimed to characterize the status of free amino acids and their metabolites in lean and obese ZSF1 rats to investigate the effects of glucose on amino acid excretion.
Article
Multidisciplinary Sciences
Petra Buttner, Sarah Werner, Svetlana Baskal, Dimitrios Tsikas, Volker Adams, Philipp Lurz, Christian Besler, Sarah Knauth, Martin Bahls, Edzard Schwedhelm, Holger Thiele
Summary: Obese ZSF1 rats with HFpEF showed significantly lower levels of lysine, arginine, homoarginine, and nitrite in serum, while ornithine and citrulline levels were higher. Expression of arginine-consuming enzymes in the liver and kidney remained unchanged, but arginase 1 expression from granulocyte origin in serum was significantly higher, along with increased cardiac macrophage invasion. These findings suggest that inflammatory cells in blood and heart consume arginine and homoarginine, potentially reducing arginine bioavailability to endothelial NO synthase.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Lisa Schulz, Sarah Werner, Julia Boettner, Volker Adams, Philipp Lurz, Christian Besler, Holger Thiele, Petra Buettner
Summary: Diastolic dysfunction in HFpEF is associated with alterations in the cardiac microtubule network, including increased concentration and detyrosination levels of alpha-tubulin. The decreased tyrosination/alpha-tubulin ratio suggests potential contributions to diastolic dysfunction in HFpEF and highlights MT homeostasis as a new target for pharmacological interventions.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Petra Buettner, Volker Adams, Sarah Werner, Susann Ossmann, Christian Besler, Edzard Schwedhelm, Holger Thiele
Summary: The study found that decreased hArg levels in patients with HFpEF are associated with alterations in left ventricular and skeletal muscle function and structure. However, hArg supplementation may be beneficial for right ventricular function in HFpEF patients.
Article
Biology
Julia Boettner, Sarah Werner, Volker Adams, Sarah Knauth, Angela Kricke, Holger Thiele, Petra Buettner
Summary: This study used a TAC mouse model to investigate the effects of exercise training on cardiac remodeling and peripheral cachexia. The results showed that peripheral cachexia was not significant in the TAC model, but exercise training exacerbated HF symptoms, indicating that the severe TAC model is not suitable for studying the beneficial effects of moderate exercise on HF.
BIOLOGICAL RESEARCH
(2021)