Possible FDA-approved drugs to treat Ebola virus infection

Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1

(2014) Wei Xu et al.   Cell Host & Microbe

Disseminated intravascular coagulation: Testing and diagnosis

(2014) Hideo Wada et al.   CLINICA CHIMICA ACTA

The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

(2014) Gerrit Gehring et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Elucidation of the Ebola Virus VP24 Cellular Interactome and Disruption of Virus Biology through Targeted Inhibition of Host-Cell Protein Function

(2014) Isabel García-Dorival et al.   JOURNAL OF PROTEOME RESEARCH

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

(2014) Travis K. Warren et al.   NATURE

Comprehensive Functional Analysis of N-Linked Glycans on Ebola Virus GP1

(2014) N. J. Lennemann et al.   mBio

Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus

(2014) Kang Lai et al.   Infectious Diseases of Poverty

Antiviral therapies targeting host ER alpha-glucosidases: Current status and future directions

(2013) Jinhong Chang et al.   ANTIVIRAL RESEARCH

Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses

(2013) Jinhong Chang et al.   ANTIVIRAL RESEARCH

Miglustat: A Review of Its Use in Niemann-Pick Disease Type C

(2013) Katherine A. Lyseng-Williamson   DRUGS

Multiple Cationic Amphiphiles Induce a Niemann-Pick C Phenotype and Inhibit Ebola Virus Entry and Infection

(2013) Charles J. Shoemaker et al.   PLoS One

Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail

(2013) J. Pettitt et al.   Science Translational Medicine

FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection

(2013) L. M. Johansen et al.   Science Translational Medicine

Drugs to cure avian influenza infection – multiple ways to prevent cell death

(2013) S Yuan   Cell Death & Disease

The Secret Life of Viral Entry Glycoproteins: Moonlighting in Immune Evasion

(2013) Jonathan D. Cook et al.   PLoS Pathogens

TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine

(2013) Stephanie Jemielity et al.   PLoS Pathogens

Pathogenesis of the Viral Hemorrhagic Fevers

(2012) Slobodan Paessler et al.   Annual Review of Pathology-Mechanisms of Disease

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Antioxidant Therapy: Current Status and Future Prospects

(2012) O. Firuzi et al.   CURRENT MEDICINAL CHEMISTRY

Filoviruses Require Endosomal Cysteine Proteases for Entry but Exhibit Distinct Protease Preferences

(2012) J. Misasi et al.   JOURNAL OF VIROLOGY

Productive Replication of Ebola Virus Is Regulated by the c-Abl1 Tyrosine Kinase

(2012) M. Garcia et al.   Science Translational Medicine

Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression

(2012) Kerstin Gnirß et al.   VIROLOGY

Cathepsin B & L Are Not Required for Ebola Virus Replication

(2012) Andrea Marzi et al.   PLoS Neglected Tropical Diseases

Antigenic Subversion: A Novel Mechanism of Host Immune Evasion by Ebola Virus

(2012) Gopi S. Mohan et al.   PLoS Pathogens

Ebola haemorrhagic fever outbreak in Masindi District, Uganda: outbreak description and lessons learned

(2011) Matthias Borchert et al.   BMC INFECTIOUS DISEASES

Population pharmacokinetic and exposure-response analysis of nilotinib in patients with newly diagnosed Ph+ chronic myeloid leukemia in chronic phase

(2011) Richard A. Larson et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Antibody-Dependent Enhancement of Marburg Virus Infection

(2011) Eri Nakayama et al.   JOURNAL OF INFECTIOUS DISEASES

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

(2011) A. S. Kondratowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diagnosis and treatment of disseminated intravascular coagulation: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)

(2011) Marcello Di Nisio et al.   THROMBOSIS RESEARCH

The role of high-dose imatinib in the management of patients with gastrointestinal stromal tumor

(2010) Alessandro Gronchi et al.   CANCER

Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches

(2010) Anton I. Rosenbaum et al.   JOURNAL OF NEUROCHEMISTRY

The Tyro3 Receptor Kinase Axl Enhances Macropinocytosis of Zaire Ebolavirus

(2010) C. L. Hunt et al.   JOURNAL OF VIROLOGY

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

(2010) Thomas W Geisbert et al.   LANCET

Advanced antisense therapies for postexposure protection against lethal filovirus infections

(2010) Travis K Warren et al.   NATURE MEDICINE

Human Fatal Zaire Ebola Virus Infection Is Associated with an Aberrant Innate Immunity and with Massive Lymphocyte Apoptosis

(2010) Nadia Wauquier et al.   PLoS Neglected Tropical Diseases

Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes

(2010) Mohammad F. Saeed et al.   PLoS Pathogens

Haptoglobin: Basic and Clinical Aspects

(2009) Andrew P. Levy et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

(2008) Jeffrey E. Lee et al.   NATURE