Epigenetic regulation in adult stem cells and cancers

Asymmetric distribution of histones during Drosophila male germline stem cell asymmetric divisions

(2013) Vuong Tran et al.   CHROMOSOME RESEARCH

Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche

(2013) L. Tarayrah et al.   DEVELOPMENT

Identification of a histone acetyltransferase as a novel regulator ofDrosophilaintestinal stem cells

(2013) Yansen Ma et al.   FEBS LETTERS

HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis

(2013) M. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TET1 plays an essential oncogenic role in MLL-rearranged leukemia

(2013) H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

(2012) Christine Guo Lian et al.   CELL

Asymmetric Stem Cell Division: Precision for Robustness

(2012) Mayu Inaba et al.   Cell Stem Cell

Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia

(2012) Shannon J. Gallagher et al.   DEVELOPMENTAL BIOLOGY

Phf7 Controls Male Sex Determination in the Drosophila Germline

(2012) Shu Yuan Yang et al.   DEVELOPMENTAL CELL

Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains

(2012) J. J. Trowbridge et al.   GENES & DEVELOPMENT

The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells

(2012) Oleksandra Karpiuk et al.   MOLECULAR CELL

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

(2012) Abed AlFatah Mansour et al.   NATURE

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

(2012) H Yang et al.   ONCOGENE

Asymmetric Division of Drosophila Male Germline Stem Cell Shows Asymmetric Histone Distribution

(2012) V. Tran et al.   SCIENCE

TET1 Suppresses Cancer Invasion by Activating the Tissue Inhibitors of Metalloproteinases

(2012) Chih-Hung Hsu et al.   Cell Reports

CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia

(2011) H. Makishima et al.   BLOOD

EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling

(2011) Chun-Ju Chang et al.   CANCER CELL

Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties

(2011) J. Wang et al.   CANCER RESEARCH

Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor microRNAs and Attenuating EZH2 Expression

(2011) B. Bao et al.   CANCER RESEARCH

Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

(2011) Piul Rabbani et al.   CELL

Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential

(2011) J M Heddleston et al.   CELL DEATH AND DIFFERENTIATION

Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

(2011) Wen-Hui Lien et al.   Cell Stem Cell

Regulation of Intestinal Stem Cell Proliferation by Human Methyl-CpG-binding Protein-2 in Drosophila

(2011) Shin-Hae Lee et al.   CELL STRUCTURE AND FUNCTION

piRNA Production Requires Heterochromatin Formation in Drosophila

(2011) Prashanth Rangan et al.   CURRENT BIOLOGY

Jarid2 regulates mouse epidermal stem cell activation and differentiation

(2011) Stefania Mejetta et al.   EMBO JOURNAL

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

(2011) E. Ezhkova et al.   GENES & DEVELOPMENT

Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer

(2011) Francesco Crea et al.   Molecular Cancer

Ovarian Cancer Stem Cell-Like Side Populations Are Enriched Following Chemotherapy and Overexpress EZH2

(2011) S. Rizzo et al.   MOLECULAR CANCER THERAPEUTICS

Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary

(2011) S. Eliazer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation

(2011) Xiaoxi Wang et al.   PLoS Genetics

A Role for Set1/MLL-Related Components in Epigenetic Regulation of the Caenorhabditis elegans Germ Line

(2011) Tengguo Li et al.   PLoS Genetics

Sertoli Cells Dictate Spermatogonial Stem Cell Niches in the Mouse Testis

(2010) M. J. Oatley et al.   BIOLOGY OF REPRODUCTION

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

(2010) Sascha Seidel et al.   BRAIN

The ATAC Acetyltransferase Complex Coordinates MAP Kinases to Regulate JNK Target Genes

(2010) Tamaki Suganuma et al.   CELL

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq

(2010) Qiang Gan et al.   CELL RESEARCH

Epigenetic Regulation of Stem Cell Maintenance in the Drosophila Testis via the Nucleosome-Remodeling Factor NURF

(2010) Christopher M. Cherry et al.   Cell Stem Cell

Key Roles for Transforming Growth Factor β in Melanocyte Stem Cell Maintenance

(2010) Emi K. Nishimura et al.   Cell Stem Cell

Epigenetic regulation of germ cell differentiation

(2010) Suk Ho Eun et al.   CURRENT OPINION IN CELL BIOLOGY

Jarid2 and PRC2, partners in regulating gene expression

(2010) G. Li et al.   GENES & DEVELOPMENT

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

(2010) Myunggon Ko et al.   NATURE

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

(2010) Eric L. Greer et al.   NATURE

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

(2010) Diego Pasini et al.   NATURE

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Active DNA demethylation: many roads lead to Rome

(2010) Susan C. Wu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sin3a Is Required by Sertoli Cells to Establish a Niche for Undifferentiated Spermatogonia, Germ Cell Tumors, and Spermatid Elongation

(2010) Christopher J. Payne et al.   STEM CELLS

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration

(2009) Valentina Greco et al.   Cell Stem Cell

DrosophilaG9a is implicated in germ cell development

(2009) K.-S. Lee et al.   INSECT MOLECULAR BIOLOGY

Regulation of intestinal stem cells in mammals andDrosophila

(2009) Ping Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

(2008) Sean J. Morrison et al.   CELL

Germ Cells Are Forever

(2008) Ryan M. Cinalli et al.   CELL

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

(2008) X. Li et al.   JNCI-Journal of the National Cancer Institute

The cancer stem cell hypothesis: in search of definitions, markers and relevance

(2008) Michail Shipitsin et al.   LABORATORY INVESTIGATION

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

(2008) Liqin Zhu et al.   NATURE

Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells

(2008) Guonan Lin et al.   NATURE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding

(2008) Tamaki Suganuma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

Drosophila Stem Cells Share a Common Requirement for the Histone H2B Ubiquitin Protease Scrawny

(2008) M. Buszczak et al.   SCIENCE

Epigenetic Regulation of Mammalian Stem Cells

(2008) Xuekun Li et al.   STEM CELLS AND DEVELOPMENT