Journal
FEBS LETTERS
Volume 587, Issue 10, Pages 1489-1495Publisher
WILEY
DOI: 10.1016/j.febslet.2013.03.013
Keywords
Histone acetyltransferase; Atac2; Intestinal stem cell; Drosophila
Funding
- VDRC
- NIG-Fly
- Bloomington Drosophila Stock Center and University of Iowa Developmental Studies Hybridoma Bank for flies and reagents
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One of the major challenges in stem cell research is to decipher the controlling mechanisms/genes of stem cell homeostasis. Through an RNAi mediated genetic screen of living animals, we identified an evolutionarily conserved histone acetyltransferase Atac2 as a novel regulator of Drosophila intestinal stem cells (ISCs). Expression of Atac2-RNAi or a dominant negative allele of Atac2 generated more ISCs, while excessive Atac2 or a histone deacetylase inhibitor promoted ISC differentiation without affecting ISC survival or lineage specification. These findings extend our knowledge of epigenetic mechanisms in stem cell regulation.
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