4.6 Article

The effects of energy balance, obesity-proneness and sex on the neuronal response to sweet taste

Journal

BEHAVIOURAL BRAIN RESEARCH
Volume 278, Issue -, Pages 446-452

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2014.10.024

Keywords

fMRI; Neuroimaging; Sucrose; Underfeeding; Overfeeding; Sex

Funding

  1. NIH/NCRR Colorado CTSI Grant [UL1 TR000154]
  2. NIH/NIDDK Nutrition Obesity Research Center [DK48520]
  3. NIH/NIDDK [R01DK072174]

Ask authors/readers for more resources

We have previously shown that propensity for weight gain, energy balance state and sex are important determinants of the neuronal response to visual food cues. It is not clear, though, whether these factors also impact the neuronal response to taste. The objective of this study was to examine the neuronal response to sweet taste during energy imbalance in men and women recruited to be obesity-prone (OP) or obesity-resistant (OR). OP (13 men and 12 women) and OR (12 men and 12 women) subjects were studied after 1 day of eucaloric, overfed and underfed conditions in a randomized crossover design. On each test day, fMRI was performed in the respective acute fed state while subjects received in random order 60 trials each of 1 M sucrose solution (SU), or artificial saliva (AS) following a visual cue predicting the taste. The neuronal response to SU versus AS expectation was significantly greater in the amygdala, orbitofrontal cortex, putamen and insula in OR versus OP; SU receipt was not different between groups. There were also sex-based differences with men having greater neuronal response to SU versus AS receipt in the caudate than women. The results, however, were not impacted by the state of energy balance. In summary, response to expectation but not receipt of basic sweet taste was different in OR compared to OP, highlighting the importance of learning and conditioning in the propensity to gain weight. Response to sucrose taste receipt was stronger in men than women, raising questions about the effect of sex hormones on brain response to food. (C) 2014 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Neurosciences

The Neural Correlates of Cued Reward Omission

Jessica A. Mollick, Luke J. Chang, Anjali Krishnan, Thomas E. Hazy, Kai A. Krueger, Guido K. W. Frank, Tor D. Wager, Randall C. O'Reilly

Summary: This study focuses on negative prediction error signals and examines the pathway through the lateral habenula in humans using high-resolution functional MRI. Results show activations in midbrain dopamine regions, insula, and orbitofrontal cortex during reward presentation and reward-predictive cues, but uncorrected activity in the habenula requires further replication. Pallidum and putamen regions of the basal ganglia showed modulations of activity for the inhibitor that did not survive the corrected threshold.

FRONTIERS IN HUMAN NEUROSCIENCE (2021)

Article Psychiatry

Body size overestimation in anorexia nervosa: Contributions of cognitive, affective, tactile and visual information

Tiffany A. Brown, Megan E. Shott, Guido K. W. Frank

Summary: This study compared females with AN and matched healthy controls on a perceptual size estimation task, finding that individuals with AN were more likely to overestimate their body size. Body dissatisfaction was found to have a significant impact on this overestimation.

PSYCHIATRY RESEARCH (2021)

Article Neurosciences

Persistence, Reward Dependence, and Sensitivity to Reward Are Associated With Unexpected Salience Response in Girls but Not in Adult Women: Implications for Psychiatric Vulnerabilities

Guido K. W. Frank, Megan E. Shott, Lot C. Sternheim, Skylar Swindle, Tamara L. Pryor

Summary: The study found that adolescent girls showed stronger reward processing and temperament associations compared to adult women. This is important for understanding the development of adaptive or maladaptive behavior patterns during the transition from adolescence to adulthood.

BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING (2022)

Editorial Material Psychology, Clinical

Introduction to a special issue on eating disorders and gastrointestinal symptoms-The chicken or the egg?

Guido K. W. Frank, Neville H. Golden, Helen Burton Murray

INTERNATIONAL JOURNAL OF EATING DISORDERS (2021)

Editorial Material Psychology, Clinical

Open science practices for eating disorders research

Natasha L. Burke, Guido K. W. Frank, Anja Hilbert, Thomas Hildebrandt, Kelly L. Klump, Jennifer J. Thomas, Tracey D. Wade, B. Timothy Walsh, Shirley B. Wang, Ruth Striegel Weissman

Summary: This editorial advocates for increased application of open science practices in eating disorders research, including preregistration, registered reports, and the sharing of materials, data, and code. Updates and research are needed to determine the value and efficient strategies for implementing these practices.

INTERNATIONAL JOURNAL OF EATING DISORDERS (2021)

Article Psychiatry

Association of Brain Reward Response With Body Mass Index and Ventral Striatal-Hypothalamic Circuitry Among Young Women With Eating Disorders

Guido K. W. Frank, Megan E. Shott, Joel Stoddard, Skylar Swindle, Tamara L. Pryor

Summary: The study found that in participants with eating disorders, the prediction error response was elevated and inversely correlated with body mass index, indicating the importance of food intake control circuitry in the brain.

JAMA PSYCHIATRY (2021)

Review Medicine, General & Internal

From Desire to Dread-A Neurocircuitry Based Model for Food Avoidance in Anorexia Nervosa

Guido K. W. Frank

Summary: Research indicates that the environmental ambience and brain neural circuitry play crucial roles in the food avoidance behaviors of anorexia nervosa. Animal and human studies support fear conditioning to food in anorexia nervosa patients, as well as alterations in brain function and dopamine response.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Psychology, Clinical

Understanding implicit and explicit learning in adolescents with and without anorexia nervosa

Lot C. Sternheim, Miriam Wickham, Unna N. Danner, Todd W. Maddox, Vincent J. Filoteo, Megan E. Shott, Guido K. W. Frank

Summary: Cognitive disturbances such as impairments in learning are thought to play a role in adult Anorexia Nervosa (AN). It is remains unclear to what extent these disturbances result from starvation of the brain. This study found that individuals with AN, relative to their healthy peers, may be quicker in forming automatic responses and behaviors to cues, and that depression and anxiety did not influence their learning performance.

JOURNAL OF EATING DISORDERS (2021)

Article Psychology, Clinical

The potential role of stimulants in treating eating disorders

Aaron Keshen, Sara Bartel, Guido K. W. Frank, Nils Erik Svedlund, Abraham Nunes, Laura Dixon, Sarrah Ali, Allan S. Kaplan, Phillipa Hay, Stephan Touyz, Francisco Romo-Nava, Susan L. McElroy

Summary: The article suggests a new approach to treating eating disorders with stimulants, discussing research directions and risks. It emphasizes the importance of future research in this area.

INTERNATIONAL JOURNAL OF EATING DISORDERS (2022)

Article Psychology, Biological

Associations between aerobic exercise and dopamine-related reward-processing: Informing a model of human exercise engagement

Sasha Gorrell, Megan E. Shott, Guido K. W. Frank

Summary: This study found that aerobic exercise can enhance the functioning of the brain's reward circuitry, particularly in response to rewards and value computation. These findings help to explain individual differences in exercise participation and maintenance and may have therapeutic applications for conditions associated with altered brain salience response.

BIOLOGICAL PSYCHOLOGY (2022)

Article Psychology, Clinical

Brain reward response in adolescents and young adults with anorexia nervosa is moderated by changes in body weight and sweetness perception

Guido K. W. Frank, Megan E. Shott, Tamara Pryor, Skylar Swindle, Joel Stoddard

Summary: This study found elevated taste prediction error response in individuals with AN, which was largely absent after weight restoration. Changes in BMI and sweet taste perception were independent moderators of change in brain salience response in adolescents and young adults with AN. The study suggests that food-related and nonfood-related reward processing adapts to illness state in AN.

INTERNATIONAL JOURNAL OF EATING DISORDERS (2022)

Article Neurosciences

Trait anxiety is associated with amygdala expectation and caloric taste receipt response across eating disorders

Guido K. W. Frank, Megan E. Shott, Tamara Pryor, Skylar Swindle, Tyler Nguyen, Joel Stoddard

Summary: This study examined the relationship between anxious traits and neurobiology in individuals with eating disorders (EDs). The results showed that amygdala sucrose expectation response was elevated in anorexia nervosa and this relationship was negatively moderated by trait anxiety across EDs. The findings suggest that trait anxiety may play an important role in driving taste stimulus receipt brain response and food approach in individuals with EDs.

NEUROPSYCHOPHARMACOLOGY (2023)

Article Psychiatry

Ketogenic diet and ketamine infusion treatment to target chronic persistent eating disorder psychopathology in anorexia nervosa: a pilot study

Lori Calabrese, Barbara Scolnick, Beth Zupec-Kania, Caroline Beckwith, Kayla Costello, Guido K. W. Frank

Summary: This study investigated the use of a ketogenic diet and ketamine treatment for adults with chronic anorexia nervosa. The results showed significant improvements in clinical impairment, eating disorder symptoms, and acceptance of self and body. The treatment appears to be safe and effective in reducing AN-related psychopathology.

EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY (2022)

Article Psychiatry

I know I am not out of control, but I just cannot shake the feeling: exploring feeling out of control in eating disorders

Lisa Adler, Tiffany A. Brown, Megan E. Shott, Skylar Swindle, Guido K. W. Frank

Summary: Individuals with anorexia and bulimia nervosa often have a fear of loss of control during eating, with differing levels of self-perceived control over food intake. Anxious traits may contribute to this fear, and intolerance of uncertainty is correlated with these issues in healthy controls specifically.

EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY (2022)

Article Medicine, General & Internal

A longitudinal case series of IM ketamine for patients with severe and enduring eating disorders and comorbid treatment-resistant depression

Terry Schwartz, Mary Ellen Trunko, David Feifel, Emily Lopez, Danika Peterson, Guido K. W. Frank, Walter Kaye

Summary: Ketamine treatment shows promise in improving depression in patients with treatment-resistant depression and enduring eating disorders.

CLINICAL CASE REPORTS (2021)

Article Behavioral Sciences

Photomodulatory effects in the hypothalamus of sleep-deprived young and aged rats

Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy

Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

N-acetylcysteine ameliorates chemotherapy-induced impaired anxiety and depression-like behaviors by regulating inflammation, oxidative and cholinergic status, and BDNF release

Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik

Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

Continuous high-frequency repetitive transcranial magnetic stimulation at extremely low intensity affects exploratory behavior and spatial cognition in mice

Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu

Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

Alterations in regional homogeneity and functional connectivity in the cerebellum of patients with sporadic amyotrophic lateral sclerosis

Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang

Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

Clinical effects of anodal tDCS and identifying response markers in post-traumatic stress disorder (PTSD): An open-label study

Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri

Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

Self-esteem and cortical thickness correlate with aggression in healthy children: A surface-based analysis

Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo

Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

Parental involvement affects parent-adolescents brain-to-brain synchrony when experiencing different emotions together: An EEG-based hyperscanning study

Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao

Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

Role of serotonin in the lack of sensitization caused by prolonged food deprivation in Aplysia

Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi

Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

The effects of a dual orexin receptor antagonist on fear extinction memory and sleep in mice: Implications for exposure therapy

Ihori Kobayashi, Patrick A. Forcelli

Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice

Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia

Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

Coordination function index: A novel indicator for assessing hindlimb locomotor recovery in spinal cord injury rats based on catwalk gait parameters

Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning

Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

Transcranial alternating current stimulation does not affect microscale learning

Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi

Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

Protective effect of vitamin D on learning and memory impairment in rats induced by high fructose corn syrup

Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral

Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

Orexin receptors in the hippocampal dentate gyrus modulated the restraint stress-induced analgesia in the animal model of chronic pain

Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast

Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.

BEHAVIOURAL BRAIN RESEARCH (2024)

Article Behavioral Sciences

Low-dose Esketamine suppresses NLRP3-mediated apoptotic and pyroptotic cell death in microglial cells to ameliorate LPS-induced depression via ablating GSK-3β

Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan

Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.

BEHAVIOURAL BRAIN RESEARCH (2024)