Chromatin Dynamics in the Regulation of CFTR Expression

Oxidative Stress RegulatesCFTRGene Expression in Human Airway Epithelial Cells through a Distal Antioxidant Response Element

(2015) Zhaolin Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

CHD6 regulates the topological arrangement of the CFTR locus

(2015) Ana Sancho et al.   HUMAN MOLECULAR GENETICS

Chromatin remodeling mediated by the FOXA1/A2 transcription factors activatesCFTRexpression in intestinal epithelial cells

(2014) Jenny L Kerschner et al.   Epigenetics

Transcription factors and miRNAs that regulate fetal to adult CFTR expression change are new targets for cystic fibrosis

(2014) V. Viart et al.   EUROPEAN RESPIRATORY JOURNAL

CFTR mRNA expression is regulated by an upstream open reading frame and RNA secondary structure in its 5′ untranslated region

(2014) Samuel W. Lukowski et al.   HUMAN MOLECULAR GENETICS

CTCF: an architectural protein bridging genome topology and function

(2014) Chin-Tong Ong et al.   NATURE REVIEWS GENETICS

Architectural proteins CTCF and cohesin have distinct roles in modulating the higher order structure and expression of the CFTR locus

(2014) N. Gosalia et al.   NUCLEIC ACIDS RESEARCH

Global view of enhancer-promoter interactome in human cells

(2014) B. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Mediators Regulate CFTR Expression through a Bifunctional Airway-Selective Enhancer

(2013) Z. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromatin Insulators: Linking Genome Organization to Cellular Function

(2013) Jennifer E. Phillips-Cremins et al.   MOLECULAR CELL

Nucleosome mapping across the CFTR locus identifies novel regulatory factors

(2013) Erbay Yigit et al.   NUCLEIC ACIDS RESEARCH

Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells

(2013) J. Zuin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Transcriptional networks driving enhancer function in theCFTRgene

(2012) Jenny L. Kerschner et al.   BIOCHEMICAL JOURNAL

The Chromatin Fingerprint of Gene Enhancer Elements

(2012) Gabriel E. Zentner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: From fixation to computation

(2012) Erik Splinter et al.   METHODS

The long-range interaction landscape of gene promoters

(2012) Amartya Sanyal et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

MiR-101 and miR-144 Regulate the Expression of the CFTR Chloride Channel in the Lung

(2012) Fatemat Hassan et al.   PLoS One

A microRNA network regulates expression and biosynthesis of wild-type and  F508 mutant cystic fibrosis transmembrane conductance regulator

(2012) S. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse Developmental Disorders from The One Ring: Distinct Molecular Pathways Underlie the Cohesinopathies

(2012) Julia A. Horsfield et al.   Frontiers in Genetics

microRNA regulation of expression of the cystic fibrosis transmembrane conductance regulator gene

(2011) Austin E. Gillen et al.   BIOCHEMICAL JOURNAL

Molecular mechanisms controlling CFTR gene expression in the airway

(2011) Zhaolin Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Determinants of nucleosome organization in primary human cells

(2011) Anton Valouev et al.   NATURE

Enhancer function: new insights into the regulation of tissue-specific gene expression

(2011) Chin-Tong Ong et al.   NATURE REVIEWS GENETICS

Synergistic Post-Transcriptional Regulation of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) by miR-101 and miR-494 Specific Binding

(2011) Francesca Megiorni et al.   PLoS One

A unique chromatin signature uncovers early developmental enhancers in humans

(2010) Alvaro Rada-Iglesias et al.   NATURE

Cell-type-specific long-range looping interactions identify distant regulatory elements of the CFTR gene

(2010) Nele Gheldof et al.   NUCLEIC ACIDS RESEARCH

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Mechanisms Influence Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Gene Promoter

(2009) Marzena A. Lewandowska et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cohesin: Its Roles and Mechanisms

(2009) Kim Nasmyth et al.   Annual Review of Genetics

Interaction of intestinal and pancreatic transcription factors in the regulation of CFTR gene expression

(2009) Victoria A. McCarthy et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

CTCF: Master Weaver of the Genome

(2009) Jennifer E. Phillips et al.   CELL

An oestrogen-receptor-α-bound human chromatin interactome

(2009) Melissa J. Fullwood et al.   NATURE

An insulator element 3′ to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells

(2009) Neil P. Blackledge et al.   NUCLEIC ACIDS RESEARCH

Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus

(2009) C. J. Ott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

(2008) Mathieu Lupien et al.   CELL

Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms

(2008) Vania Parelho et al.   CELL

A complex intronic enhancer regulates expression of theCFTRgene by direct interaction with the promoter

(2008) Christopher J. Ott et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cohesin mediates transcriptional insulation by CCCTC-binding factor

(2008) Kerstin S. Wendt et al.   NATURE

CTCF physically links cohesin to chromatin

(2008) E. D. Rubio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA