Imaging Multimodalities for Dissecting Alzheimer's Disease: Advanced Technologies of Positron Emission Tomography and Fluorescence Imaging

A Highly Selective and Specific PET Tracer for Imaging of Tau Pathologies

(2018) Wei Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Postmortem 3-D Brain Hemisphere Cortical Tau and Amyloid-β Pathology Mapping and Quantification as a Validation Method of Neuropathology Imaging

(2018) Lojze M. Smid et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

(2018) David T. Chien et al.   JOURNAL OF ALZHEIMERS DISEASE

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

(2015) Marta Marquié et al.   ANNALS OF NEUROLOGY

The methodology of TSPO imaging with positron emission tomography

(2015) Federico E. Turkheimer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Quantification of [18F]DPA-714 Binding in the Human Brain: Initial Studies in Healthy Controls and Alzheimer'S Disease Patients

(2015) Sandeep SV Golla et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future

(2015) Manuela Ariza et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical Fluorescent Probe for Detection of Aβ Oligomers

(2015) Chai Lean Teoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tau imaging: early progress and future directions

(2015) Victor L Villemagne et al.   LANCET NEUROLOGY

Molecular Spies for Bioimaging—Fluorescent Protein-Based Probes

(2015) Atsushi Miyawaki et al.   MOLECULAR CELL

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice

(2015) Jack Brelstaff et al.   Frontiers in Neuroscience

Amyloid PET imaging in Alzheimer’s disease: a comparison of three radiotracers

(2014) S. M. Landau et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vivo evaluation of a novel tau imaging tracer for Alzheimer’s disease

(2014) Victor L. Villemagne et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Positron Emission Tomography in CNS Drug Discovery and Drug Monitoring

(2014) Markus Piel et al.   JOURNAL OF MEDICINAL CHEMISTRY

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

(2013) Chun-Fang Xia et al.   Alzheimers & Dementia

Inhibiting toxic aggregation of amyloidogenic proteins: A therapeutic strategy for protein misfolding diseases

(2013) Biao Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Aza-BODIPY: Improved synthesis and interaction with soluble Aβ1–42 oligomers

(2013) Laramie P. Jameson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging

(2013) Tetsuro Tago et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

A Rapid Gene Delivery-Based Mouse Model for Early-Stage Alzheimer Disease-Type Tauopathy

(2013) Robert Siman et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Optogenetic pharmacology for control of native neuronal signaling proteins

(2013) Richard H Kramer et al.   NATURE NEUROSCIENCE

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

Biomarker Modeling of Alzheimer’s Disease

(2013) Clifford R. Jack et al.   NEURON

Optical fibers for high-resolution in vivo microendoscopic fluorescence imaging

(2013) Gyungseok Oh et al.   OPTICAL FIBER TECHNOLOGY

Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg4510 Model of Tauopathy

(2013) Katherine J. Kopeikina et al.   PLoS One

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

(2013) K. V. Kuchibhotla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Are Tau Aggregates Toxic or Protective in Tauopathies?

(2013) Catherine M. Cowan et al.   Frontiers in Neurology

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer’s disease pathology

(2012) Ryuichi Harada et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Molecular imaging of microglia/macrophages in the brain

(2012) Sriram Venneti et al.   GLIA

Noninvasive Molecular Imaging of Neuroinflammation

(2012) Andreas H Jacobs et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography

(2012) David A Wolk et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyloid-  Imaging with Pittsburgh Compound B and Florbetapir: Comparing Radiotracers and Quantification Methods

(2012) S. M. Landau et al.   JOURNAL OF NUCLEAR MEDICINE

Clinical Validation of 18F-AZD4694, an Amyloid- -Specific PET Radioligand

(2012) Z. Cselenyi et al.   JOURNAL OF NUCLEAR MEDICINE

Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease

(2012) Nikita Rudinskiy et al.   NATURE NEUROSCIENCE

Genetically encoded optical indicators for the analysis of neuronal circuits

(2012) Thomas Knöpfel   NATURE REVIEWS NEUROSCIENCE

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Brain Amyloid Imaging — FDA Approval of Florbetapir F18 Injection

(2012) Lucie Yang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular imaging of dementia

(2012) Takaaki MORI et al.   Psychogeriatrics

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

Single particle analysis of tau oligomer formation induced by metal ions and organic solvents

(2011) Benedikt Bader et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

(2011) M. T. Fodero-Tavoletti et al.   BRAIN

Characterization of Prefibrillar Tau Oligomersin Vitroand in Alzheimer Disease

(2011) Kristina R. Patterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Are Tangles as Toxic as They Look?

(2011) Tara L. Spires-Jones et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Targeting Post-translational Modifications on Tau as a Therapeutic Strategy for Alzheimer's Disease

(2011) Jacob Newman Marcus et al.   JOURNAL OF NEUROGENETICS

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Long-Term In Vivo Imaging of  -Amyloid Plaque Appearance and Growth in a Mouse Model of Cerebral  -Amyloidosis

(2011) J. K. Hefendehl et al.   JOURNAL OF NEUROSCIENCE

Clinical amyloid imaging in Alzheimer's disease

(2011) Karl Herholz et al.   LANCET NEUROLOGY

Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy

(2011) Robert P J Barretto et al.   NATURE MEDICINE

Positron Emission Tomography Radiopharmaceuticals for Imaging Brain Beta-Amyloid

(2011) Shankar Vallabhajosula   SEMINARS IN NUCLEAR MEDICINE

A Novel 18F-Labeled Imidazo[2,1-b]benzothiazole (IBT) for High-Contrast PET Imaging of β-Amyloid Plaques

(2011) Behrooz H. Yousefi et al.   ACS Medicinal Chemistry Letters

ANS Binding Reveals Common Features of Cytotoxic Amyloid Species

(2010) Benedetta Bolognesi et al.   ACS Chemical Biology

18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial

(2010) Rik Vandenberghe et al.   ANNALS OF NEUROLOGY

Preparation and Characterization of Neurotoxic Tau Oligomers

(2010) Cristian A. Lasagna-Reeves et al.   BIOCHEMISTRY

In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: Insights from neuroimaging research in humans and rodent models

(2010) Makoto Higuchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography

(2010) Tarik F Massoud et al.   NATURE MEDICINE

Advances in Light Microscopy for Neuroscience

(2009) Brian A. Wilt et al.   Annual Review of Neuroscience

Triazole-containing BODIPY dyes as novel fluorescent probes for soluble oligomers of amyloid Aβ1–42 peptide

(2009) Nicholas W. Smith et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer’s disease pathologies

(2009) Paul W. Thompson et al.   JOURNAL OF NEUROCHEMISTRY

A Reporter of Local Dendritic Translocation Shows Plaque- Related Loss of Neural System Function in APP-Transgenic Mice

(2009) M. Meyer-Luehmann et al.   JOURNAL OF NEUROSCIENCE

Preclinical Properties of 18F-AV-45: A PET Agent for A  Plaques in the Brain

(2009) S. R. Choi et al.   JOURNAL OF NUCLEAR MEDICINE

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

A Soluble Oligomer of Tau Associated with Fiber Formation Analyzed by NMR

(2008) Dylan W. Peterson et al.   BIOCHEMISTRY

In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons

(2008) T. L. Spires-Jones et al.   JOURNAL OF NEUROSCIENCE

Imaging of Peripheral Benzodiazepine Receptor Expression as Biomarkers of Detrimental versus Beneficial Glial Responses in Mouse Models of Alzheimer's and Other CNS Pathologies

(2008) B. Ji et al.   JOURNAL OF NEUROSCIENCE

Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-A  Antibody Administration in PDAPP Mice

(2008) J. Koenigsknecht-Talboo et al.   JOURNAL OF NEUROSCIENCE

Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism

(2008) Christopher C Rowe et al.   LANCET NEUROLOGY

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Extrinsic Fluorescent Dyes as Tools for Protein Characterization

(2008) Andrea Hawe et al.   PHARMACEUTICAL RESEARCH

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE