Article
Pharmacology & Pharmacy
Brandon W. Lewis, Maria L. Ford, Aiman Q. Khan, Joshua Walum, Rodney D. Britt
Summary: Type 2-high severe asthma is a distinct subtype characterized by Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. Acute and chronic allergen models induce type 2 inflammation, but the differences in corticosteroid sensitivity remain unclear. This study found that chronic allergen exposure is associated with more persistent type 2 immune responses and corticosteroid insensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Jing Zhang, Yuan Zou, Longmin Chen, Qianqian Xu, Yi Wang, Min Xie, Xiansheng Liu, Jianping Zhao, Cong-Yi Wang
Summary: Asthma is a multifactorial disorder characterized by chronic inflammation, hyper-responsiveness, remodeling, and reversible obstruction. Recent studies suggest that most cases are Th2-high type and regulatory T cells (Tregs) play an essential role in limiting the development of allergic diseases. Researchers are exploring new treatment methods based on Tregs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Amlan Chakraborty, Anita A. Pinar, Maggie Lam, Jane E. Bourke, Simon G. Royce, Cordelia Selomulya, Chrishan S. Samuel
Summary: This study conjugated relaxin to nanoparticles and delivered them intranasally to a preclinical rodent model of chronic allergic airways disease and collagen gel contraction from asthma patient-derived myofibroblasts, showing potential anti-remodeling and anti-inflammatory effects, which could be important for treating the central features of asthma.
Article
Immunology
Mohammad Gholami, Khodayar Ghorban, Mahvash Sadeghi, Maryam Dadmanesh, Negin Hosseini Rouzbahani, Sajad Dehnavi
Summary: This review summarizes the potential therapeutic effects of mesenchymal stem cells (MSCs) on allergic airway inflammations. The studies suggest that MSCs can modulate airway inflammation, affect inflammatory cell infiltration, balance Th1/Th2 cellular responses, disrupt humoral responses, regulate Th17/Treg cell balance, and modulate macrophage and dendritic cell function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Jinmei Zhang, Zhengcan Wu, Fenfang Yu, Liang Ye, Wei Gu, Yan Tan, Li Wang, Ying Shi
Summary: The research found that LXRs can increase airway inflammation and hyperresponsiveness, as well as promote airway remodeling, suggesting that inhibiting LXRs may be a potential method for treating allergic asthma.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Immunology
Katherine A. Kaiser, Lucas F. Loffredo, Kenia de los Santos-Alexis, Olivia R. Ringham, Nicholas Arpaia
Summary: This research reveals the interaction between Treg cells and lung mesenchymal cells, mediated by the signaling molecule amphiregulin, to support alveolar regeneration following influenza virus infection. The study uncovers a crucial immune/mesenchymal/epithelial network that plays a vital role in maintaining lung function and preventing infections.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Cell Biology
Zijian Zeng, Mengxin Cheng, Meng Li, Tao Wang, Fuqiang Wen, Michael J. Sanderson, James Sneyd, Yongchun Shen, Jun Chen
Summary: BALB/c and C57BL/6 mouse strains are commonly used as animal models for respiratory diseases. This study found that BALB/c mice have a stronger extent of small airway narrowing and faster Ca2+ oscillations in airway smooth muscle (ASM) cells in response to agonists. These differences are associated with an increased store-operated Ca2+ entry (SOCE) current, resulting in higher airway responsiveness in BALB/c mice compared to C57BL/6 mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Yuzhi Lu, Ni Xia, Xiang Cheng
Summary: Regulatory T cells (Tregs) play a crucial role in the development of chronic heart failure, suppressing excessive inflammatory responses and promoting stable scar formation in the early stage of heart injury. However, in chronic heart failure, the functions and phenotypes of Tregs change, transforming into a cell type that is harmful to the heart.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Ryan C. Murphy, Ying Lai, Matthew Liu, Taha Al-Shaikhly, Matthew C. Altman, William A. Altemeier, Charles W. Frevert, Jason S. Debley, Adrian M. Piliponsky, Steven F. Ziegler, Sina A. Gharib, Teal S. Hallstrand
Summary: This study identified differentially expressed genes associated with exercise-induced bronchoconstriction in individuals with asthma using RNA-sequencing analysis. Experiments suggested that the interactions between airway epithelial cells, mast cells, and eosinophils are closely associated with indirect airway hyperresponsiveness and play a critical role in modulating airway inflammation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Cell & Tissue Engineering
Zhiping Wei, Jintao Yuan, Gaoying Wang, Dickson Kofi Wiredu Ocansey, Zhiwei Xu, Fei Mao
Summary: Research has shown that MSCs have potential therapeutic effects in autoimmune diseases. In addition to treating fractures and tissue repair, MSCs can help restore immune homeostasis by regulating T cell subsets.
STEM CELLS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Wen-Chung Huang, Shu-Ju Wu, Kuo-Wei Yeh, Chian-Jiun Liou
Summary: Our study found that Gypenoside A can alleviate airway inflammation and hyperreactivity in asthmatic mice by reducing the expression of inflammatory cytokines and inhibiting the activation of Th2 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Giuseppina Bertorelli, Beatrice Ludovica Ritondo, Paola Rogliani, Alfredo Chetta
Summary: AHR is a central pathophysiological feature of asthma, involving ASM with pro-inflammatory and immunomodulatory actions. mAbs target various inflammatory mediators to modulate ASM contractility, showing potential in treating severe asthma by preventing AHR.
Review
Allergy
Ryan C. Murphy, Teal S. Hallstrand
Summary: Recent studies have shed light on the central role of mast cells in regulating lower airway inflammation and airway hyperresponsiveness.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mojdeh Matloubi, Latifa Koussih, Lianyu Shan, Chelsea Lukawy, Abdelilah S. Gounni
Summary: Asthma is a heterogeneous airway disease characterized by airway inflammation and remodeling, affecting more than 300 million people worldwide and posing a significant burden on society. Semaphorin3E, a critical molecule in lung pathophysiology, plays a role in both lung development and homeostasis. Recent studies have demonstrated that the Semaphorin3E-plexinD1 axis is implicated in asthma, impacting inflammatory and structural cells associated with airway inflammation, tissue remodeling, and airway hyperresponsiveness. This review highlights the potential role of the Semaphorin3E-plexinD1 axis as a therapeutic target in airway allergic diseases.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Chi-Chien Lin, Kai-Cheng Chuang, Shih-Wei Chen, Ya-Hsuan Chao, Chih-Ching Yen, Shang-Hsun Yang, Wei Chen, Kuang-Hsi Chang, Yu-Kang Chang, Chuan-Mu Chen
Summary: Lactoferrin exhibits anti-inflammation and immunoregulation activities in OVA-induced allergic asthma, ameliorating lung injury, decreasing Th2 cytokines and allergen-specific antibodies production, and influencing the functions of dendritic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)