Review
Pharmacology & Pharmacy
Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kamila Raziyeva, Laura Tabyldiyeva, Kamila Berikova, Dias Zhumagul, Kamila Temirkhanova, Arman Saparov
Summary: Chitosan, a biopolymer derived from chitin, has great potential for tissue regeneration and controlled drug delivery. It possesses qualities such as biocompatibility, low toxicity, and antimicrobial activity, making it attractive for biomedical applications. Chitosan can be fabricated into different structures, including nanoparticles, scaffolds, hydrogels, and membranes, which can be customized for specific outcomes. It has been shown to stimulate tissue regeneration and repair in various tissues and organs, and is an efficient carrier for medications, genes, and bioactive compounds.
Article
Engineering, Biomedical
Xiongfa Ji, Hongwei Shao, Xiaohong Li, Muhammad Wajid Ullah, Guowen Luo, Ziyang Xu, Limin Ma, Xuecheng He, Zehua Lei, Qian Li, Xulin Jiang, Guang Yang, Yu Zhang
Summary: The inappropriate regeneration of fibrous cartilage and subchondral bone can lead to the failure of cartilage repair. A macrophage-modulated and injectable drug delivery system was developed to promote cartilage and subchondral bone regeneration. This system effectively created a microenvironment that facilitated the regeneration process.
Review
Pharmacology & Pharmacy
Nimeet Desai, Dhwani Rana, Sagar Salave, Raghav Gupta, Pranav Patel, Bharathi Karunakaran, Amit Sharma, Jyotsnendu Giri, Derajram Benival, Nagavendra Kommineni
Summary: Chitosan, derived from chitin, is a promising material for drug delivery and biomedical applications. Different extraction techniques can produce chitosan with unique properties, which can be further modified to enhance bioactivities. Chitosan-based drug delivery systems have been developed for various administration routes, allowing for targeted and sustained release of drugs. It has also been used in biomedical applications such as tissue regeneration and gene delivery. Modified chitosan derivatives offer innovative materials with potential in biomedical applications. This article summarizes recent findings on chitosan and its applications in drug delivery and biomedical science.
Article
Chemistry, Physical
Arjan Atwal, Tina P. Dale, Martyn Snow, Nicholas R. Forsyth, Pooya Davoodi
Summary: The impairment of articular cartilage poses challenges, but recent advancements in regenerative medicine, particularly the use of injectable hydrogels, offer promising prospects for cartilage regeneration. Hydrogels can mimic the characteristics of native cartilage and provide minimally invasive delivery of bioactive agents to the damaged site, accelerating cartilage healing and modulating inflammation.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Chemistry, Applied
Amol D. Gholap, Satish Rojekar, Harshad S. Kapare, Nikhar Vishwakarma, Sarjana Raikwar, Atul Garkal, Tejal A. Mehta, Harsh Jadhav, Mahendra Kumar Prajapati, Uday Annapure
Summary: Chitosan, a natural polysaccharide derived from chitin, holds great potential as a biomaterial in various biomedical applications due to its biocompatibility, biodegradability, antibacterial activity, and ease of modification. This review provides an overview of the use of chitosan scaffolds in tissue engineering, regenerative medicine, and drug delivery systems. It highlights the structural and biological properties of chitosan and explores different fabrication methods, such as gelation, electrospinning, and 3D printing. The review emphasizes the role of chitosan scaffolds in promoting cell adhesion, proliferation, and differentiation for tissue regeneration, as well as their potential in wound healing and infection management. Additionally, it discusses the challenges and future objectives in scaffold design, mechanical properties, and understanding interactions with host tissues.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Timothee Baudequin, Celine Agnes, Maryam Tabrizian
Summary: Recent engineering strategies involve co-encapsulation of cell lineages and/or growth factors in multi-compartmental scaffolds to mimic native tissue architecture. This study introduces a core-shell platform based on chitosan and guanosine diphosphate for co-culture, showing potential for the regeneration of multiple tissues with stable cell population and enhanced cellular functionality. Proof-of-concept co-culture of MC-3T3 and endothelial cells demonstrated homogeneous distribution within their intended compartment in the core-shell scaffold.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Celine J. Agnes, Monzur Murshed, Adrien Takada, Bettina M. Willie, Maryam Tabrizian
Summary: Effective treatments for critical size bone defects remain challenging. 6-Bromoindirubin-3 '-Oxime (BIO), a glycogen synthase kinase 3fi inhibitor, is incorporated into a new formulation of the guanosine diphosphate cross-linked chitosan scaffold to promote osteogenic differentiation. The results of a proof-of-concept study suggest a dose-dependent response of BIO on early stages of osteogenic differentiation within the scaffold.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Materials Science, Multidisciplinary
Yuanfeng Li, Junjie Chi, Xing Dong, Anh-Tuan Le, Keqing Shi, Yong Liu, Jian Xiao
Summary: G-quadruplex hydrogel is a self-assembled supramolecular hydrogel formed by guanine derivatives, which shows wide biomedical applications such as drug delivery, tissue engineering, and biosensing. Its advantages include biocompatibility, tunable multifunctionality, and cost-effective fabrication process. This review focuses on the fabrication and characterization of G-quadruplex hydrogels, as well as their applications in the biomedical area, aiming to promote the development of this field.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fengjiao Zhang, Sufeng Zhang, Rui Lin, Shuyuan Cui, Xiaokai Jing, Sergiu Coseri
Summary: This study successfully synthesized an injectable and self-healing pH-responsive hydrogel that can be used as a carrier for drug delivery systems. The hydrogel exhibited notable mechanical properties, good self-healing ability, pH responsiveness, and excellent antibacterial properties. It also showed a high drug loading capacity and sustained drug release behavior, as well as good cytocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Jiang Bian, Feng Cai, Hao Chen, Zhenzhou Tang, Kun Xi, Jincheng Tang, Liang Wu, Yichang Xu, Lianfu Deng, Yong Gu, Wenguo Cui, Liang Chen
Summary: The injectable peptide-cell-hydrogel microsphere showed promising results in regulating ECM metabolism and inhibiting inflammatory responses, providing an effective approach for tissue regeneration under overactive inflammatory conditions.
Article
Biochemistry & Molecular Biology
Shuang Han, Hongye Yang, Xiaoqi Ni, Yunfan Deng, Zubing Li, Xin Xing, Minquan Du
Summary: In this study, a novel injectable dual-drug programmed releasing chitosan nanofibrous microsphere-based PLGA-PEG-PLGA hydrogel was developed, which significantly promoted both angiogenesis and bone formation. This research provides a promising approach for improving bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Yong Hu, Yuan Xu, Bing Wang, Yun Chen, Chao Huang
Summary: A methacrylated catechol-chitosan (MCCS) adhesive hydrogel was prepared by crosslinking chitosan with 2,3,4-trihydroxybenzaldehyde and methacrylic anhydride, followed by photopolymerization. The MCCS adhesive hydrogel exhibited ideal elasticity, good mechanical properties, and improved adhesive strength. It also showed controllable degradation rate, good cell compatibility, and antibacterial activity.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Shih-Ho Lin, Abel Po-Hao Huang, Shan-hui Hsu
Summary: Stroke is a global disease with high mortality, and the regeneration of neural tissue during intracerebral hemorrhage stroke is limited by various factors. To overcome this limitation, a chitosan micellar self-healing hydrogel is developed as an injectable implant for brain tissue regeneration. The hydrogel has similar properties to the brain, including shape adaptability and proper swelling. It can release two different drugs with asynchronous kinetics, providing targeted treatment for different phases of the stroke. In animal models, the hydrogel shows promising results in terms of behavioral improvement, balanced brain midline shift, and evidence of neurogenesis and angiogenesis.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Joey Hui Min Wong, Rebekah Pei Ting Tan, Jun Jie Chang, Benjamin Qi Yu Chan, Xinxin Zhao, Jayce Jian Wei Cheng, Yong Yu, Yi Jian Boo, Qianyu Lin, Valerie Ow, Xinyi Su, Jason Y. C. Lim, Xian Jun Loh, Kun Xue
Summary: Researchers have developed injectable hydrogels with excellent antifatigue properties and shape stability through tuning their mechanical properties and utilizing hybrid crosslinking. These hydrogels show high stability, sustained release properties, and >90% recovery during cyclic compression tests.
Article
Pharmacology & Pharmacy
Fanghao Chen, Yide He, Zhe Li, Boya Xu, Qingyuan Ye, Xinyan Li, Zhiwei Ma, Wen Song, Yumei Zhang
Summary: A new injectable DNA hydrogel was synthesized through heat-cool treatments and chitosan cross-linkage, showing excellent biocompatibility and drug delivery properties.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
