Article
Chemistry, Multidisciplinary
Philipp Gerdt, Armido Studer
Summary: A method has been developed for the synthesis of functionalized alternating copolymers by reversible deactivation radical polymerization, allowing for the generation of a small library of novel alternating terpolymers with diverse functionalities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Kazuya Maruyama, Arihiro Kanazawa, Sadahito Aoshima
Summary: This study investigated the structural difference of cyclic acetals in cationic copolymerization with vinyl monomers, and found that the substituents of cyclic acetals significantly affected the electronic and steric environments around the carbocation generated in the propagation reaction, which in turn affected the frequency of crossover reactions. Acid hydrolysis of alternating copolymers resulted in complete degradation and selective generation of a single compound due to the periodic incorporation of acetal structures in the main chains.
Article
Chemistry, Multidisciplinary
Anwesha Chakraborty, Pradipta Kumar Das, Biman Jana, Suhrit Ghosh
Summary: This article reports on the alternating supramolecular copolymerization of two NDI-derived building blocks and discusses their optical properties and theoretical predictions. The experimental results show that the mixed sample forms a gel and a fibrillar network, unlike the individual components. The theoretical predictions and experimental results are consistent, indicating that the copolymer has alternating stacking sequences and exhibits efficient FRET.
Article
Chemistry, Multidisciplinary
Anwesha Chakraborty, Pradipta Kumar Das, Biman Jana, Suhrit Ghosh
Summary: This article reports the alternating supramolecular copolymerization of two NDI-derived building blocks under thermodynamic control, leading to the formation of a gel with a fibrillar network structure. The resulting alternating supramolecular copolymers showed highly efficient fluorescence resonance energy transfer (FRET).
Article
Chemistry, Physical
Sheryl Cherian Parakkal, Riya Datta, A. Saral, S. Muthu, Ahmad Irfan, A. Jeelani
Summary: The current work focuses on the synthesis, characterization, and computational evaluation of 3,3,5-triphenylfuran-2(3H)-one. Various techniques, including density functional theory (DFT) and molecular docking, were used to analyze the structure, properties, and pharmacological potential of the compound. The findings suggest that the compound has the capability to inhibit anticancer proteins.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
N. Elangovan, T. Sankar Ganesan, R. Vignesh, Suliman Yousef Alomar, S. Sowrirajan, S. Chandrasekar, Abdul Nasar Kalanthoden, Asad Nawaz
Summary: In this study, a new compound CS7 was synthesized using a specific synthesis method, and its properties were characterized using various spectroscopic techniques. Theoretical calculations and experimental methods showed good agreement, and the compound's physicochemical properties and interactions were investigated using different computational approaches.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Ting-Wei Hsu, Samuel J. Kempel, Alyssa P. Felix Thayne, Quentin Michaudel
Summary: In this study, a stereoretentive acyclic diene metathesis polymerization method was developed to control the cis/trans geometry of polyalkenamers. This method exhibited low catalyst loadings and tolerance towards trans impurities, enabling the synthesis of various polymers with predictable cis:trans ratios. The impact of the stereochemistry of the repeating alkenes on the thermal properties was clearly demonstrated.
Article
Polymer Science
Thomas M. McGuire, Ella F. Clark, Antoine Buchard
Summary: In this study, a D-xylose 3,5-anhydrosugar derivative was used as an oxetane co-monomer in the ring-opening copolymerization (ROCOP) with cyclic anhydrides to synthesize a family of seven novel sugar-derived polyesters with up to 100% renewable content. These polyesters are thermally robust and exhibit a broad range of glass-transition temperatures, allowing for further postpolymerization functionalization. The living character of the ROCOP process was also utilized to synthesize block copolymers through sequential co-monomer addition experiments.
Article
Polymer Science
Yongyao Lei, Yougen Chen
Summary: Eight novel alternating copolymers were successfully synthesized through the post-polymerization modification of poly(propylene-alt-allyl alcohol)100 (PPAA100), which cannot be accessed using general methodologies. The chemical transformations of the hydroxyl group in PPAA100 resulted in the formation of eight unique head-to-head alternating copolymers with fixed propylene structural units and allyl alcohol derived monomeric units. The obtained polymers were characterized using 1H and 13C NMR and FT-IR spectroscopies, and their thermal properties were investigated.
Article
Polymer Science
Jintao Li, Mingzu Zhang, Jinlin He, Peihong Ni
Summary: In this study, the anionic homopolymerization, random and block copolymerizations of several vinyl monomers were explored in deep eutectic solvent (DES). The microstructures and molecular weights of the polymers were characterized, and their thermal properties were investigated. The results showed that DES can be used to prepare polymerization products with desired characteristics, and it can be recycled for multiple reactions without affecting the final product. The use of DES as a reaction medium for anionic polymerization offers milder reaction conditions and expands the application of active organolithium reagents.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Taeyang An, Hanseul Ryu, Tae-Lim Choi
Summary: This study presents a versatile approach to improve the alternation and degradability of 2,3-dihydrofuran (DHF) copolymers by carefully controlling the reactivity of both the Ru initiators and the monomers. The DHF copolymers showed outstanding A, B-alternation and could be broken down to a single repeat unit level under acidic conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Kentaro Shibata, Yuki Kametani, Yuji Daito, Makoto Ouchi
Summary: In this work, an acrylamide-based terpolymer was synthesized using a rational design approach to achieve efficient and selective cyclopolymerization. The resulting terpolymer exhibits a unique thermal response behavior.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Polymer Science
Naoya Kanbayashi, Ryoga Yamamoto, Taka-aki Okamura, Kiyotaka Onitsuka
Summary: Cyclocopolymerization is a highly selective reaction that can construct novel polymer backbones with cyclic structures. Proper additives can facilitate the reaction and improve the molar mass distribution of the polymer.
Article
Chemistry, Multidisciplinary
Emmanuelle Schue, Dillon R. L. Rickertsen, Angie B. Korpusik, Alafate Adili, Daniel Seidel, Brent S. Sumerlin
Summary: We developed a straightforward approach to synthesizing alternating styrene-propylene and styrene-ethylene copolymers by combining radical polymerizations and powerful post-polymerization modification reactions. This method demonstrates wide applicability for functional polymer synthesis.
Article
Chemistry, Multidisciplinary
Yixuan Mei, Kaihao Chen, Jiayu Gu, Jun Ling, Xufeng Ni
Summary: This study reports the successful synthesis of a copolymer of 2-methyltetrahydrofuran (2-MeTHF) and beta-butyrolactone (BBL) through Sc(OTf)(3)-catalysed cationic ring-opening copolymerization. The possibility of copolymerization was verified by density functional theory (DFT) calculations. The obtained copolymer, poly(2-MeTHF-co-BBL), showed promising properties and potential as an environmentally friendly material.
Article
Polymer Science
William R. Archer, Agustin Fiorito, Sherrie L. Heinz-Kunert, Piper L. MacNicol, Samantha A. Winn, Michael D. Schulz
Article
Polymer Science
William R. Archer, Tiffany N. Thompson, Michael D. Schulz
Summary: Research shows that alterations in the copolymer structure do not affect the overall binding thermodynamics of REEs to these copolymers.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Polymer Science
Brady A. Hall, Elliot B. Shelton, Yudian Wu, Michael D. Schulz
Summary: In this study, a series of poly(arylene ether sulfone) (PAE) copolymers with pendant alkenes were synthesized using benzenesulfonamides as comonomers, and the thermal properties of the resulting polymers were found to be dependent on the choice of sulfonamide regioisomer. Ortho/meta and meta/meta benzenesulfonamides were insensitive to thiol-ene modification, while other substitution patterns showed significant variations in properties based on the functional group installed.
Review
Chemistry, Multidisciplinary
Madison Bardot, Michael D. Schulz
Article
Chemistry, Physical
William R. Archer, Connor M. B. Gallagher, V. Vaissier Welborn, Michael D. Schulz
Summary: Metal-chelating polymers play a crucial role in the extraction and separation of rare-earth elements. This study reveals that the interactions among water, polymer, and rare-earth elements in aqueous solution can be modulated by changing the hydrophobicity of the polymer, suggesting a new design principle for developing highly effective metal-chelating materials.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Materials Science, Multidisciplinary
William R. Archer, Nuren Iftekhar, Agustin Fiorito, Samantha A. Winn, Michael D. Schulz
Summary: Rare-earth elements (REEs) are crucial in modern technologies, and materials capable of extracting them from complex solutions are needed. Researchers synthesized a phosphonate-containing polymer resin and evaluated its absorption capability. The study observed enhanced REE uptake with decreasing ionic radii, and also found similar binding affinities across the REE series. These findings demonstrate the potential of these materials as future REE extractants.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Medicinal
Valerie Vaissier Welborn, William R. Archer, Michael D. Schulz
Summary: This study proposes to calculate intrinsic electric fields from molecular dynamics simulations to characterize the driving force behind metal ion motion in metal chelating polymers. The results show that water plays a crucial role in mediating polymer-metal ion interactions, and suggests that optimizing polymer-solvent interactions may be more important than polymer-ion interactions in designing metal chelating polymers.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Multidisciplinary
Yumeng Zhu, William R. Archer, Katlyn F. Morales, Michael D. Schulz, Yin Wang, John B. Matson
Summary: Inducing high levels of reactive oxygen species (ROS) in tumor cells is a cancer therapy method called chemodynamic therapy (CDT). In this study, a peptide-H2S donor conjugate complexed with Fe2+ called AAN-PTC-Fe2+ was developed. AAN tripeptide was specifically cleaved by legumain, an enzyme overexpressed in glioma cells, to release carbonyl sulfide (COS) which hydrolyzed to form H2S. Fe2+ and H2S together increased intracellular ROS levels and decreased viability in C6 glioma cells. AAN-PTC-Fe2+ performed better than temozolomide without cytotoxicity towards H9C2 cardiomyocytes. This study provides an H2S-amplified, enzyme-responsive platform for synergistic cancer treatment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Connor M. B. Gallagher, Michael D. Schulz
Summary: Rare-earth elements (REEs) are crucial in modern technologies, and the development of alternative separation techniques using metal-binding polymers requires understanding of interactions between metal ions and polymers in solution. This study investigates the effect of ionic strength on REE chelation by poly(acrylic acid) using isothermal titration calorimetry (ITC). The results show that increasing ionic strength by sodium acetate buffer or sodium chloride affects the polymer-REE binding differently. The findings highlight the importance of ionic strength in polymer-metal binding thermodynamics and will guide the development of new processes for critical metals purification.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Materials Science, Biomaterials
Gillian A. A. Su, Ophelia J. Wadsworth, H. Suzanne Muller, William R. Archer, Steven W. Hetts, Michael D. Schulz
Summary: Researchers have developed a new class of fully synthetic drug-capture materials that integrate nucleobases into a crosslinked resin. These materials demonstrated effective capture of doxorubicin, capturing up to 27 mg per g of material within 20 minutes. Compared to previous materials that used genomic DNA, this approach is more cost-effective and reduces potential immunological concerns.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Polymer Science
William R. Archer, Taoyi Chen, Valerie Vaissier Welborn, Michael D. Schulz
Summary: This study investigates the influence of polymer tacticity on polymer-lanthanide interactions in aqueous solution and demonstrates that altering the polymer stereochemistry can affect the thermodynamics of metal binding. The results from experiments and simulations suggest that the differences in binding thermodynamics can be largely attributed to variations in polymer flexibility.
Article
Polymer Science
William R. Archer, Grace E. Dinges, Piper L. MacNicol, Michael D. Schulz
Summary: In this study, bottlebrush polymers with polyaziridine brushes and a polynorbornene backbone were synthesized by a grafting-through approach. Dynamic light scattering (DLS) was used to investigate the aggregation behavior of macromonomers and the growth of bottlebrush chains during the polymerization process.
Article
Polymer Science
Rachel H. Bianculli, Jonathan D. Mase, Michael D. Schulz
Review
Chemistry, Physical
William R. Archer, Michael D. Schulz
Article
Chemistry, Multidisciplinary
Tianyi Liu, Zhijia Du, Xianyang Wu, Muhammad Mominur Rahman, Dennis Nordlund, Kejie Zhao, Michael D. Schulz, Feng Lin, David L. Wood, Ilias Belharouak
CHEMICAL COMMUNICATIONS
(2020)
