Article
Biochemistry & Molecular Biology
Huiting Jia, Xindong Wang, Zhaoming Chen, Shuai Liu, Tongtong Zhou, Hao Zhou, Tianying Guo
Summary: Zinc ion complexes of dipicolylamine analogs have been used as a third component in the PEI1.8k/DNA gene delivery system to improve in vitro transfection performance, and the effects of different structural characteristics on the ternary complex have been systematically investigated. This ternary hybrid system provides an effective strategy to enhance gene delivery of cationic polymers.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
Arpan Bera, Srishti Gautam, Md Kausar Raza, Apurba Kumar Pal, Paturu Kondaiah, Akhil R. Chakravarty
Summary: This study investigates the synthesis, characterization, and in vitro cytotoxicity of dipicolylamine (dpa) based platinum(ii) complexes. The results demonstrate that these complexes exhibit strong photodynamic therapy (PDT) activity and low chemotherapy activity, inducing apoptosis under red light irradiation and forming adducts with DNA. The complexes preferentially localize in mitochondria and endoplasmic reticulum. These findings provide insights for the development of novel PDT agents.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Yui Sasaki, Kohei Ohshiro, Kiyosumi Okabe, Xiaojun Lyu, Kazuhiko Tsuchiya, Akira Matsumoto, Shin-ya Takizawa, Tsuyoshi Minami
Summary: In this study, a novel amphiphilic polythiophene-based chemosensor functionalized with a Zn(II)-dipicolylamine side chain was proposed for the pattern recognition of oxyanions. Optical changes induced by the formation of a random coil structure resulted in blueshifts in the UV-vis absorption spectra and turn-on-type fluorescence responses.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Review
Chemistry, Organic
Sandra Behren, Ulrika Westerlind
Summary: The interactions between bacterial lectins and carbohydrates on the host cell surface play a crucial role in bacterial adhesion and other processes. Synthetic multivalent glycoconjugates can provide insights into the nature of glycan-bacteria interactions and contribute to the design of effective bacterial inhibitors.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Zhen Xu, Tianhui Shi, Fengye Mo, Wenqian Yu, Yu Shen, Qunying Jiang, Fuan Wang, Xiaoqing Liu
Summary: In this study, programmable DNA-protein superstructures were successfully assembled through biomimetic assembly, by combining programmable polymer DNA wire with alkaline protein protamine to form densely packed DNA nanospheres. These DNA-protein superstructures exhibited specifically high affinity and stability, enabling high cancer cell selectivity and reduced side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Applied
Ahmed S. M. Al-Janabi, Mustafa M. Kadhim, Amenah I. A. Al-Nassiry, Tarek A. Yousef
Summary: Mixed ligand complexes of Zn (II) and Pd (II) were prepared with different amine ligands, such as Bipy, Phen, and 3Apy. Characterization of the obtained complexes and testing of their antimicrobial activity were conducted. Additionally, density functional theory calculations were performed to evaluate the physical and chemical parameters of the complexes.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Shohei Minagawa, Shoji Fujiwara, Takeshi Hashimoto, Takashi Hayashita
Summary: In this study, a novel supramolecular sensing system was designed using a Zn(II)-dipicolylamine metal complex-based azobenzene (1-Zn) and 3A-amino-3A-deoxy-(2AS,3AS)-gamma-cyclodextrin (3-NH2-gamma-CyD) for sensing adenosine-5 '-triphosphate (ATP). Metal coordination interaction and electrostatic interaction were found to play key roles in ATP recognition. This research represents a first step towards the development of a selective sensing system based on a good understanding of supramolecular structures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Ching-Hua Tsai, Tai-Yu Chiu, Chiung-Tong Chen, Chia-Yu Hsu, Ya-Ru Tsai, Teng-Kuang Yeh, Kuan-Hsun Huang, Lun Kelvin Tsou
Summary: In this study, an efficient Ugi multicomponent reaction and click chemistry approach were used to synthesize a series of bioactive zinc(II) dipicolylamine (ZnDPA)-based SN-38 conjugates. Comparative studies were conducted to identify a potent ZnDPA-based conjugate for pancreatic cancer treatment, which showed an 80% reduction in cytotoxic payload compared to the marketed drug irinotecan.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Leilei Sun, Yao Huang, Chenhui Ji, Craig A. Grimes, Qingyun Cai
Summary: In this study, two lanthanide-doped core-shell nanoparticles were designed for multiplexed imaging in the NIR-II region. The nanoparticles exhibited different emission wavelengths under specific excitation wavelengths, allowing for specific imaging and differentiation of Gram-positive and Gram-negative bacteria. In vitro and in vivo experiments confirmed the effectiveness of these nanoparticles in detecting different types of bacteria. The biocompatibility of the nanoprobes was also demonstrated through various assays and analyses.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Agronomy
Benjamin Costerousse, Joel Quattrini, Roman Gruter, Emmanuel Frossard, Cecile Thonar
Summary: Green manuring can increase the availability of zinc in soil, potentially increasing wheat zinc concentrations. The stimulation of bacterial activity by green manure plays a key role in mobilizing zinc in the soil.
Article
Biochemistry & Molecular Biology
Milana Bazayeva, Andrea Giachetti, Marco Pagliai, Antonio Rosato
Summary: Classical molecular dynamics (MD) simulations are commonly used to study the behavior of zinc(II)-proteins at the atomic level. In this study, the accuracy of two force fields (ZAFF and NBFF) in reproducing the dynamic behavior of zinc(II)-proteins was assessed using six zinc-fingers as benchmark. The results indicated that both force fields can accurately reproduce protein dynamics with comparable accuracy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Shuai Wang, Lichong Gong, Georges El Fakhri, Junfeng Wang
Summary: Efficient synthesis of 6,6'-diamido-2,2'-dipicolylamines (DA-DPAs) for phosphate anion sensing via pre-formed metal complexes was reported in this study. The design was based on retrosynthetic analysis, enabling functionalized DA-DPAs to be obtained with satisfactory yields and high purity using the Boekelheide rearrangement. Additionally, all intermediates could be easily purified by silica gel column chromatography.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sara Bertuzzi, Ana Gimeno, Ane Martinez-Castillo, Marta G. Lete, Sandra Delgado, Cristina Airoldi, Marina Rodrigues Tavares, Marketa Blahova, Petr Chytil, Vladimir Kren, Nicola G. A. Abrescia, Ana Arda, Pavla Bojarova, Jesus Jimenez-Barbero
Summary: The interaction of multi-LacNAc-containing HPMA copolymers with human galectin-1 and galectin-3 was analyzed through NMR, cryo-EM, and DLS experiments. The study showed stronger interaction with Gal-3 CRD for the trivalent ligand arrangement, while large cross-linked supramolecules were observed for Gal-1 in the presence of multivalent LacNAc entities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Tingyi Luo, Xianfeng Ren, Lixia Fan, Changying Guo, Bingchun Zhang, Jingxiu Bi, Shuai Guan, Mingxiao Ning
Summary: This study cloned two galectin-4 gene isoforms and found that they play an important role in immune response in Procambarus clarkia. The experimental results indicate that these two isoforms mediate the innate immune response by recognizing and agglutinating bacteria, as well as regulating the expression of antimicrobial peptides. These findings are of great significance for understanding the function and immune resistance of galectins in crustaceans.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Jiayong Liu, Hongxia Li, Haizhou Li, Shanfang Fang, Jinguo Shi, Yongzhi Chen, Rongcui Zhong, Shouping Liu, Shuimu Lin
Summary: The novel series of amphiphiles synthesized in this study showed strong Zn2+ chelating ability and exhibited effective broad-spectrum antimicrobial activity with low hemolytic activity and cytotoxicity. In vivo efficacy was demonstrated in a murine keratitis model, making them promising candidates for treating bacterial infections.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Serhan Turkyilmaz, Craig S. Wilcox
TETRAHEDRON LETTERS
(2017)
Article
Chemistry, Multidisciplinary
Serhan Turkyilmaz, Wen-Hua Chen, Hideyuki Mitomo, Steven L. Regen
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2009)
Article
Chemistry, Multidisciplinary
Vaclav Janout, Serhan Turkyilmaz, Minghui Wang, Yao Wang, Yuichi Manaka, Steven L. Regen
Article
Chemistry, Multidisciplinary
Serhan Turkyilmaz, Hideyuki Mitomo, Wen-Hua Chen, Steven L. Regen
Article
Chemistry, Multidisciplinary
Serhan Turkyilmaz, Paulo F. Almeida, Steven L. Regen
Article
Chemistry, Multidisciplinary
Martin R. Krause, Serhan Turkyilmaz, Steven L. Regen
Article
Radiology, Nuclear Medicine & Medical Imaging
Douglas R. Rice, Adam J. Plaunt, Serhan Turkyilmaz, Miles Smith, Yuzhen Wang, Mary Rusckowski, Bradley D. Smith
MOLECULAR IMAGING AND BIOLOGY
(2015)
Article
Chemistry, Organic
Serhan Turkyilmaz, Douglas R. Rice, Rachael Palumbo, Bradley D. Smith
ORGANIC & BIOMOLECULAR CHEMISTRY
(2014)
Article
Chemistry, Organic
Shuzhang Xiao, Serhan Turkyilmaz, Bradley D. Smith
TETRAHEDRON LETTERS
(2013)
Article
Materials Science, Paper & Wood
Kaan Demirel, Ozan Yilmaz, Dogan Akbulut, Serhan Turkyilmaz
Summary: Spherical materials capable of binding to negatively charged biomembrane bearing species have various applications in the removal of bacterial cells from liquids, such as in blood for the diagnosis and treatment of bacteremia, as well as in aqueous foodstuffs, pharmaceutical formulations, and wastewater discharges. The study demonstrates the preparation of BDPA-bearing nonporous cellulose microspheres for the sequestration of negatively charged biomembrane bearing species and their high binding capacities for Escherichia coli and Staphylococcus aureus. These materials show potential for future applications in the sequestration of bacterial cells and similar membrane properties from liquids.
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
D. R. Rice, S. Turkyilmaz, R. O. Palumbo, K. M. Harmatys, B. D. Smith
JOURNAL OF NUCLEAR MEDICINE
(2013)
Meeting Abstract
Biophysics
Steven L. Regen, Serhan Turkyilmaz
BIOPHYSICAL JOURNAL
(2011)
Article
Chemistry, Organic
CS Wilcox, S Turkyilmaz
TETRAHEDRON LETTERS
(2005)
Article
Chemistry, Multidisciplinary
CS Wilcox, V Gudipati, HJ Lu, S Turkyilmaz, DP Curran
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2005)