Article
Cardiac & Cardiovascular Systems
Yang Li, Shijuan Gao, Yingchun Han, Li Song, Yu Kong, Yao Jiao, Shan Huang, Jie Du, Yulin Li
Summary: This study investigated the genetic characteristics of sporadic isolated thoracic aortic aneurysm (iTAA) and revealed the potential role of focal adhesion scaffold genes in the pathogenesis of iTAA. Pathogenic mutations and suspected functional variants were found to be significantly enriched in iTAA patients, with Testin (TES) identified as a potential causal gene. The study also showed that knockdown of focal adhesion scaffold genes like TLN1 and ZYX resulted in decreased contractility of vascular smooth muscle cells in iTAA patients.
CIRCULATION RESEARCH
(2021)
Article
Environmental Sciences
Xiao Ke, Wenyu Guo, Yanren Peng, Zongming Feng, Yi-teng Huang, Ming Deng, Min-xin Wei, Zan-xin Wang
Summary: This study found that Stmn2 may play a crucial role in vascular injury and is associated with vascular smooth muscle cell phenotype transformation. Further research is needed to elucidate the detailed molecular mechanisms of Stmn2 in vascular injury.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Junyuan Lv, Xintong Li, Hongyu Wu, Jiayang Li, Boyang Luan, Yiqi Li, Yeli Li, Danli Yang, Hao Wen
Summary: The study found that ICS-II can effectively attenuate vascular remodeling process and promote VSMC contractile phenotype, with the mechanism possibly involving modulation of the focal adhesion signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physiology
Cedric H. G. Neutel, Callan D. Wesley, Guido R. Y. De Meyer, Wim Martinet, Pieter-Jan Guns
Summary: In this study, the ex vivo viscoelastic properties of different regions of the aorta in healthy adult mice were investigated, as well as the interplay between altered cyclic stretch and viscoelasticity. The results showed that the viscoelastic parameters increase along the distal aorta and that the effect of altered cyclic stretch is region dependent. The study also identified vascular smooth muscle cells as an important modulator of viscoelasticity. Overall, the findings suggest that cyclic stretch can modulate aortic viscoelasticity by acting on vascular smooth muscle cell focal adhesion. Rating: 8/10.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Viviano Gomes de Oliveira Neves, Marcela M. Blascke de Mello, Daniel Rodrigues, Laena Pernomian, Isadora Sousa de Oliveira, Juliana M. Parente, Eliane Candiani Arantes, Rita C. Tostes, Michele M. Castro
Summary: During early hypertension, increased MMP-2 activity leads to the cleavage of various proteins in the extracellular matrix, promoting VSMC proliferation. Cleaved products of Type I collagen may activate focal adhesion kinases (FAK) and trigger migration and proliferation signals in VSMC.
VASCULAR PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Junchul Shin, Svyatoslav Tkachenko, Delphine Gomez, Rupande Tripathi, Gary K. Owens, Olga A. Cherepanova
Summary: OCT4 is quickly activated in SMC after acute vascular injury, inhibiting SMC hyperproliferation and potentially preventing excessive neointima formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Changhong Cai, Yonghui Wu, Lebing Yang, Yijia Xiang, Ning Zhu, Huan Zhao, Wuming Hu, Lingchun Lv, Chunlai Zeng
Summary: Our study demonstrates that sodium selenite (SSE) attenuates vascular remodeling by improving characteristic features, inhibiting proliferation and enhancing apoptosis of VSMCs. SSE also inhibits AKT and ERK signaling pathways, preventing VSMCs dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Christina Wenglen, Isak Demirel, Anna Göthlin Eremo, Magnus Grenegard, Geena Paramel
Summary: Vascular smooth muscle cells (VSMCs) play a crucial role in intimal thickening and atherosclerosis progression. This study identified the expression of the 5-HT2B receptor in human atherosclerotic lesions and its positive correlation with VSMC markers. Additionally, a selective inhibitor of the 5-HT2B receptor was found to effectively inhibit TGF131-induced collagen and CTGF production through blocking the phospho-Smad2-mediated downstream signaling. This HTR2B/TGF-131/Phospho-Smad2 pathway is critical for VSMC differentiation regulation, suggesting the 5-HT2B receptor as a potential therapeutic target for limiting TGF-131-induced VSMC differentiation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Susumin Yang, Chanhyuk Min, Hyunji Moon, Byeongjin Moon, Juyeon Lee, Jaeseon Jeon, Hagyeong Kwon, Deokyun Jang, Daeho Park
Summary: The process of engulfing apoptotic cells, known as efferocytosis, requires both intra- and extracellular calcium. The mechanism of calcium flux during efferocytosis is highly regulated, and it leads to an increase in intracellular calcium levels. However, the exact role of elevated intracellular calcium during efferocytosis is still unknown.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Kuldeep Singh, Anne B. Kim, Kathleen G. Morgan
Summary: This study revealed the important role of NMII in regulating aortic stress and stiffness, mediated through tension-dependent phosphorylation of the focal adhesion proteins FAK and paxillin.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ye Liu, Yan Duan, Nan Zhao, Xinxin Zhu, Xiaoting Yu, Shiyu Jiao, Yanting Song, Li Shi, Yutao Ma, Xia Wang, Baoqi Yu, Aijuan Qu
Summary: The study reveals that PPAR alpha plays a critical protective role in Ang II-induced hypertension by attenuating ROS production in VSMCs, providing a potential therapeutic target for hypertensive diseases.
Article
Cell Biology
Madhulika Tripathi, Brijesh Kumar Singh, Elisa A. Liehn, Sheau Yng Lim, Keziah Tikno, David Castano-Mayan, Chutima Rattanasopa, Pakhwan Nilcham, Siti Aishah Binte Abdul Ghani, Zihao Wu, Syaza Hazwany Azhar, Jin Zhou, Sauri Hernandez-Resendiz, Gustavo E. Crespo-Avilan, Rohit Anthony Sinha, Benjamin Livingston Farah, Kyaw Thu Moe, Deidre Anne De Silva, Veronique Angeli, Manvendra K. Singh, Roshni R. Singaraja, Derek J. Hausenloy, Paul Michael Yen
Summary: Caffeine reduces vascular smooth muscle cell proliferation and restenosis by stimulating autophagy and inhibiting WNT signaling.
Article
Cardiac & Cardiovascular Systems
Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia G. Hsu, Vyacheslav A. Korshunov, Xiaochun Long, Peter A. Knight, Bradford C. Berk, Chen Yan
Summary: The study revealed that PDE10A contributes to SMC proliferation and intimal hyperplasia by antagonizing the CNP/NPR2/cGMP/PKG1alpha signaling pathway, suggesting that PDE10A may be a novel drug target for treating vascular occlusive disease.
CARDIOVASCULAR RESEARCH
(2022)
Article
Multidisciplinary Sciences
Taina Viheriala, Juhana Sorvari, Teemu O. Ihalainen, Anni Moro, Pyry Gronroos, Sabrina Schlie-Wolter, Boris Chichkov, Heli Skottman, Soile Nymark, Tanja Ilmarinen
Summary: The study found that after cryostorage, coating surfaces with Col-IV and LN with or without nidogen-1 significantly improved cell attachment and barrier properties of hESC-RPE. Additionally, the presence of nidogen-1 enhanced functional homogeneity of the hESC-RPE monolayer. The choice of coating proteins for cell culture may have implications for the functional properties of these cells after cryostorage cell banking.
SCIENTIFIC REPORTS
(2021)
Article
Nanoscience & Nanotechnology
Anastasia Koroleva, Andrea Deiwick, Ayman El-Tamer, Lothar Koch, Yichen Shi, Estefania Estevez-Priego, Adriaan-Alexander Ludl, Jordi Soriano, Daria Guseva, Evgeni Ponimaskin, Boris Chichkov
Summary: Neural progenitor cells derived from human induced pluripotent stem cells are crucial in brain-on-chip research, providing functional neuronal networks for in vitro modeling of cortical circuits. Utilizing advanced 3D scaffold platforms, the study demonstrates strong spontaneous neuronal activity and long-term culturing capabilities, highlighting the reliability of microstructured 3D scaffolds for modeling neuronal functions in vitro.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Optics
Filimon Zacharatos, Martin Duderstadt, Evangelos Almpanis, Lampros Patsiouras, Kestutis Kurselis, Dimitris Tsoukalas, Carsten Reinhardt, Nikolaos Papanikolaou, Boris N. Chichkov, Ioanna Zergioti
Summary: The combination of LIFT and LIBT with e-beam and nano-imprint lithography has enabled the fabrication of highly ordered arrays of Au nanoparticles embedded within Polydimethylsiloxane substrates for narrowband, strongly reflecting surfaces. These arrays exhibit resonance within the visible range and their optical characteristics are accurately predicted by finite element simulations.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Optics
Nikita Ustimenko, Kseniia Baryshnikova, Roman Melnikov, Danil Kornovan, Vladimir Ulyantsev, Boris N. Chichkov, Andrey B. Evlyukhin
Summary: The study investigated the applicability of the coupled multipole model for modeling light focusing by finite-size nanostructures of silicon nanospheres, and showed strong optimization potential for designing ultrathin metalenses using an evolutionary algorithm. The results were verified by numerical simulations and demonstrated through comparison with analytical approximations.
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
(2021)
Article
Materials Science, Multidisciplinary
Nikolai B. Chichkov, Boris N. Chichkov
Summary: The debate and controversy over the momentum of light in a dielectric medium between Abraham vs Minkowski remains unresolved. This paper investigates the origin of both momenta by considering photons in media as relativistic quasiparticles and demonstrates for the first time that the Minkowski form of photon mass, momentum, and energy follows from the relativistic energy conservation law. A new expression for the momentum of light in a dispersive medium is introduced, consistent with experimentally observed photon propagation at the group velocity, along with a discussion of light-induced optical stretching for experimental verification of existing photon momentum expressions.
OPTICAL MATERIALS EXPRESS
(2021)
Correction
Multidisciplinary Sciences
Yulia Kiyan, Sergey Tkachuk, Kestutis Kurselis, Nelli Shushakova, Klaus Stahl, Damilola Dawodu, Roman Kiyan, Boris Chichkov, Hermann Haller
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Klaus Stahl, Uta Carola Hillebrand, Yulia Kiyan, Benjamin Seeliger, Julius J. Schmidt, Heiko Schenk, Thorben Pape, Bernhard M. W. Schmidt, Tobias Welte, Marius M. Hoeper, Agnes Sauer, Malgorzata Wygrecka, Christian Bode, Heiner Wedemeyer, Hermann Haller, Sascha David
Summary: Therapeutic plasma exchange using fresh frozen plasma may play a role in mitigating endothelial glycocalyx damage in patients with septic shock, reducing injurious degradation products and partially restoring protective factors.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2021)
Article
Materials Science, Multidisciplinary
Boris Chichkov
Summary: This paper presents a personal view on the potential development and applications of laser printing technologies based on laser-induced forward transfer of inorganic and biological materials, including micro- and nanoparticles, living cells, and microorganisms.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Chemistry, Multidisciplinary
Vadim Veiko, Yuliya Karlagina, Ekaterina Zernitckaia, Elena Egorova, Maxim Radaev, Andrey Yaremenko, Gennadiy Chernenko, Valery Romanov, Nadezhda Shchedrina, Elena Ivanova, Boris Chichkov, Galina Odintsova
Summary: Laser processing of dental implant surfaces allows for control of surface structure and the creation of biomimetic topographies. The study shows that implants with continuous topography have the best secondary stability and osseointegration.
Article
Materials Science, Multidisciplinary
Mariia Matiushechkina, Andrey B. Evlyukhin, Vladimir A. Zenin, Michele Heurs, Boris N. Chichkov
Summary: To implement high-efficiency Si-nanosphere metasurface mirrors in gravitational wave detectors, the exact dimensional and configuration parameters of the total system need to be determined beforehand. The reflective properties and limitations of multi-layer metasurfaces with embedded Si nanoparticles should be investigated. This study demonstrates how the substrate and protective layer influence optical properties, as well as how dimensional and material characteristics affect light reflectivity. Manufacturing imperfections, such as variations in Si nanoparticle sizes and placement, are also considered, along with methods to maintain high reflectivity under different conditions.
Review
Crystallography
Volodymyr Vasylkovskyi, Iryna Bespalova, Mykola Slipchenko, Olena Slipchenko, Yuriy Zholudov, Boris Chichkov
Summary: This review discusses the potential application of perovskite nanostructures in electrochemiluminescent (ECL) analytical systems. Perovskite nanostructures possess unique optical, electronic, and chemical properties, making them promising materials for ECL. The review focuses on recent advances in the use of perovskite and perovskite-related nanostructures with different compositions and modifications in ECL with various media, coreactants, and reaction types. The optimal methods for perovskite nanoparticle synthesis and electrode modification are also reviewed, along with the possibilities and perspectives of using perovskite-related nanostructures for ECL generation.
Article
Physics, Multidisciplinary
Vladimir R. Tuz, Alexei V. Prokhorov, Alexander V. Shesterikov, Valentyn S. Volkov, Boris N. Chichkov, Andrey B. Evlyukhin
Summary: The emergence of new materials and fabrication techniques has contributed to the development of advanced photonic and communication devices. This paper proposes and numerically studies a metasurface made of bulk MoS2, a novel material with unique properties suitable for optical applications. By utilizing the natural anisotropy of MoS2, the metasurface is able to split electric and magnetic dipole modes and bring them into overlap by optimizing geometric parameters. At resonant frequencies, the metasurface acts as either an electric or a magnetic mirror depending on the polarization of incident light. It can be considered an alternative to traditional mirrors and optical splitters for designing compact and highly efficient metadevices that manipulate electromagnetic waves on a subwavelength scale.
ANNALEN DER PHYSIK
(2023)
Article
Chemistry, Multidisciplinary
Volodymyr Vasylkovskyi, Iryna Bespalova, Andrey Evlyukhin, Yuriy Zholudov, Iaroslav Gerasymov, Daniil Kurtsev, Denys Kofanov, Olena Slipchenko, Mykola Slipchenko, Boris Chichkov
Summary: The application of pulsed laser ablation technique for generating cerium-doped garnet nanoparticles in liquids is investigated. The morphological and optical properties of the obtained nanoparticles are demonstrated. The influence of single crystals of Gd3Al2.4Ga2.6O12:Ce3+, Lu3Al5O12:Ce3+, and Y3Al1.25Ga3.75O12:Ce3+ as well as the parameters of liquid media on the generation of garnet nanoparticles are experimentally studied using TEM and UV-Vis spectroscopy methods. The study reveals the relationship between the size, shape, and internal structure of the nanoparticles and the external laser ablation conditions and laser melting processes of NPs in the colloidal solutions. This work provides important information for the utilization of the generated nanoparticles as building blocks for structures with predetermined optical properties.
Proceedings Paper
Engineering, Electrical & Electronic
Andrei Buzykin, Yulia Karlagina, Maxim Radaev, Elena Egorova, Ekaterina Zernitskaya, Boris Chichkov, Nils Heine, Meike Stiesch, Katharina Doll, Galina Odintsova, Vadim Veiko
Summary: The study demonstrates a novel approach using laser technology to obtain TiO2 coating on a titanium mesh for controlled bone augmentation in oral implantology. This has significant implications for the antibacterial properties required in the medical application of titanium materials.
LASER-BASED MICRO- AND NANOPROCESSING XVI
(2022)
Article
Nanoscience & Nanotechnology
Dmitry N. Gulkin, Anna A. Popkova, Boris Afinogenov, Daniil A. Shilkin, Kestutis Kurselis, Boris N. Chichkov, Vladimir O. Bessonov, Andrey A. Fedyanin
Summary: Modern integrated photonic platforms should possess various features, including low-loss guiding, spectral flexibility, high light confinement, and close packing of optical components. Proper design of nanostructures can enable efficient capturing and controlling of light through various optical resonances. Research shows that a single silicon nanoparticle can serve as a subwavelength multiplexer changing the direction of BSW excitation.