Article
Neurosciences
Kai Zhou, Peng Wu
Summary: The presence of osteoarthritis interacts with the APOE4 genotype to influence longitudinal change in verbal episodic memory among non-demented older individuals, but not global cognition.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Yu Yamazaki, Chia-Chen Liu, Akari Yamazaki, Francis Shue, Yuka A. Martens, Yuanxin Chen, Wenhui Qiao, Aishe Kurti, Hiroshi Oue, Yingxue Ren, Ying Li, Tomonori Aikawa, Yesesri Cherukuri, John D. Fryer, Yan W. Asmann, Betty Y. S. Kim, Takahisa Kanekiyo, Guojun Bu
Summary: The specific expression of apoE4 in VMCs in mice was found to impair behavior and cerebrovascular function, while reducing arteriole blood flow, impairing spatial learning, and increasing anxiety-like phenotypes. The study also showed that apoE4 in VMCs was associated with astrocyte activation, while apoE3 was linked to angiogenic signature in pericytes.
Article
Nutrition & Dietetics
Yun Zhang, Xurui Jin, Michael W. Lutz, Sang-Yhun Ju, Keyang Liu, Guang Guo, Yi Zeng, Yao Yao
Summary: The study found that individuals carrying the APOE e4 allele experienced faster cognitive decline, while high DDPI and daily fish intake were associated with slower cognitive decline. Additionally, frequent fish intake was more beneficial in mitigating cognitive decline among APOE e4 allele carriers, especially for women.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Megumi T. Matsushita, Hao Wang, Glen M. Abel, Zhengui Xia
Summary: The Apolipoprotein E (ApoE) gene is a risk factor for Alzheimer's disease, with the ε4 allele carriers having higher risk. Cadmium (Cd) is a neurotoxic heavy metal. A previous study found a gene-environment interaction (GxE) effect between ApoE4 and Cd that worsens cognitive decline in mice. This study investigates the role of adult neurogenesis in rescuing Cd-induced cognitive impairment in ApoE4-KI mice and finds that stimulating adult neurogenesis can reverse spatial memory deficits and enhance neurogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Marie Caillaud, Samantha Maltezos, Carol Hudon, Samira Mellah, Sylvie Belleville
Summary: This study aimed to investigate whether hippocampal volume and APOE4 can predict inter-individual differences in memory performance among SCD individuals and identify a meaningful clinical subgroup. The results showed that hippocampal volume was the best predictor of memory performance. Comparisons between two SCD subgroups, one with small hippocampal volume and another with normal hippocampal volume, revealed that the small hippocampal volume subgroup had similar memory performance as the MCI group, while the normal hippocampal volume subgroup performed similarly to the control group.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Multidisciplinary Sciences
Joel W. Blanchard, Leyla Anne Akay, Jose Davila-Velderrain, Djuna von Maydell, Hansruedi Mathys, Shawn M. Davidson, Audrey Effenberger, Chih-Yu Chen, Kristal Maner-Smith, Ihab Hajjar, Eric A. Ortlund, Michael Bula, Emre Agbas, Ayesha Ng, Xueqiao Jiang, Martin Kahn, Cristina Blanco-Duque, Nicolas Lavoie, Liwang Liu, Ricardo Reyes, Yuan-Ta Lin, Tak Ko, Lea R'Bibo, William T. Ralvenius, David A. Bennett, Hugh P. Cam, Manolis Kellis, Li-Huei Tsai
Summary: APOE4 has widespread effects on gene expression in the human brain, particularly in relation to cholesterol homeostasis and transport. Aberrant cholesterol deposition in oligodendrocytes leads to reduced myelination, while pharmacologically facilitating cholesterol transport improves learning and memory. This study provides insights into the impact of APOE4 on the aging human brain and suggests potential therapeutic strategies for Alzheimer's disease.
Article
Public, Environmental & Occupational Health
Ping-Chen Chung, Ta-Chien Chan
Summary: This study used non-invasive digital biomarkers to quantify oral health and employed machine learning algorithms to detect cognitive decline. The results showed that oral function and oral inflammation levels were associated with cognitive decline. Maintaining oral hygiene and oral health can simultaneously assess cognitive status and enable early monitoring of cognitive status to prevent future disease burden.
Article
Psychiatry
Wenting Fang, Naian Xiao, Guirong Zeng, Daode Bi, Xiaoman Dai, Xue Mi, Qinyong Ye, Xiaochun Chen, Jing Zhang
Summary: Population-based studies have shown a close association between the apolipoprotein E (APOE) epsilon 4 gene allele and late-life depression. This gene variant may increase the risk of depression in elderly individuals by impairing glucose metabolism, reducing ATP levels, and damaging mitochondrial functions in astrocytes. ATP supplementation could potentially be effective in treating elderly depression patients with the APOE epsilon 4 gene allele.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Jing Xiong, Seong Su Kang, Mengmeng Wang, Zhihao Wang, Yiyuan Xia, Jianming Liao, Xia Liu, Shan-Ping Yu, Zhaohui Zhang, Vitaly Ryu, Tony Yuen, Mone Zaidi, Keqiang Ye
Summary: Alzheimer's disease (AD) is the most common dementia, and females with the ApoE4 allele have a higher risk and earlier onset of AD compared to males. In mice, it has been found that follicle-stimulating hormone (FSH) and ApoE4 jointly trigger the formation of AD-like pathology by activating C/EBP beta/delta-secretase signaling.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Nicola Andrea Marchi, Mathieu Berger, Geoffroy Solelhac, Virginie Bayon, Jose Haba-Rubio, Julie Legault, Cynthia Thompson, Nadia Gosselin, Peter Vollenweider, Pedro Marques-Vidal, Armin von Gunten, Marie-Pierre Francoise Strippoli, Martin Preisig, Bogdan Draganski, Raphael Heinzer
Summary: Research has found conflicting results regarding the relationship between obstructive sleep apnea and cognitive functioning in older adults, and the moderating factors of this association have not been well studied. This study investigated the association between obstructive sleep apnea and cognitive functioning in older adults, as well as the moderating effects of age, sex, apolipoprotein E4, and obesity on this association. The findings suggest that apolipoprotein E4 carriers and obese individuals may be more vulnerable to the negative effects of severe obstructive sleep apnea on processing speed.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Matthieu de Rochemonteix, Valerio Napolioni, Nilotpal Sanyal, Michael E. Belloy, Neil E. Caporaso, Maria T. Landi, Michael D. Greicius, Nilanjan Chatterjee, Summer S. Han
Summary: A robust trend test for detecting gene-environment interactions under an additive risk model was developed in this study, incorporating the gene-environment independence assumption to increase power. Numerical investigation showed that the proposed tests are more powerful than traditional tests assuming specific genetic models, with the incorporation of the independence assumption enhancing efficiency by 2.5-fold.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Psychology, Multidisciplinary
Sophie von Stumm, Radhika Kandaswamy, Jessye Maxwell
Summary: Differences in early life cognitive development are influenced by genetic and environmental factors, but it is challenging to identify replicable gene-environment interactions (GxE).
Article
Environmental Sciences
Shanshan Wang, Yingjun Xue, Jintao Zhang, Huaxing Meng, Jingsi Zhang, Xiaoyan Li, Zhuoran Zhang, Huan Li, Baolong Pan, Xiaoting Lu, Qinli Zhang, Qiao Niu
Summary: This study aimed to explore the interaction between environmental factors (aluminum exposure) and genetic factors (ApoEe4 gene) on cognitive function. After investigating 1121 in-service workers in a large aluminum factory, it was found that there is a dose-response relationship between aluminum concentration and cognitive impairment, and that the ApoEe4 gene may be a risk factor for cognitive impairment. Additionally, there is an additive interaction between aluminum concentration and the ApoEe4 gene, and when the two factors work together, the risk of cognitive impairment further increases.
Article
Green & Sustainable Science & Technology
Cassandra Johnson Gaither, Denzell A. Cross, G. Rebecca Dobbs
Summary: This exploratory study explores the association between involuntary neighborhood transiency and civic environmental stewardship in four neighborhoods adjacent to urban forest patches in Atlanta, Georgia. The study suggests that involuntary neighborhood transiency inhibits engagement with urban greenspaces, particularly in low-income African American renter communities, which are highly transient.
Article
Immunology
Ruo-Xi Chen, Meng-Di Dai, Qing-Zhao Zhang, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Xin-Jie Zhu, Zhong-Fei Wu, Zheng-Dong Zhang, Lei Cheng
Summary: This study explored the genetic association of allergic rhinitis (AR) with single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway. It found that genetic polymorphisms in TLR2 and CD14, as well as gene-gene interactions, were associated with susceptibility to AR in this Han Chinese population. However, the results regarding gene-environment interactions were limited.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Philippa J. Clarke, Jennifer Weuve, Lisa Barnes, Denis A. Evans, Carlos F. Mendes de Leon
ANNALS OF EPIDEMIOLOGY
(2015)
Article
Geriatrics & Gerontology
Kumar B. Rajan, Liesi E. Hebert, Paul A. Scherr, Carlos F. Mendes de Leon, Denis A. Evans
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2015)
Article
Public, Environmental & Occupational Health
Lindsay R. Pool, Belinda L. Needham, Sarah A. Burgard, Michael R. Elliott, Carlos F. Mendes de Leon
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2017)
Article
Public, Environmental & Occupational Health
Bart Klijs, Carlos F. Mendes de Leon, Eva U. B. Kibele, Nynke Smidt
Article
Geriatrics & Gerontology
Liming Dong, Vicki A. Freedman, Brisa N. Sanchez, Carlos F. Mendes de Leon
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2019)
Article
Geriatrics & Gerontology
George Fitchett, Maureen R. Benjamins, Kimberly A. Skarupski, Carlos F. Mendes de Leon
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2013)
Article
Clinical Neurology
Kimberly M. Henderson, Cari J. Clark, Tene T. Lewis, Neelum T. Aggarwal, Todd Beck, Hongfei Guo, Scott Lunos, Ann Brearley, Carlos F. Mendes de Leon, Denis A. Evans, Susan A. Everson-Rose
Article
Psychiatry
Liming Dong, Vicki A. Freedman, Carlos F. Mendes de Leon
PSYCHOSOMATIC MEDICINE
(2020)
Article
Geriatrics & Gerontology
Talha Ali, Michael R. Elliott, Toni C. Antonucci, Belinda L. Needham, Jon Zelner, Carlos F. Mendes de Leon
Summary: This study examined the diversity and complexity of social support networks among older adults and developed a multidimensional typology of these networks. The results identified five distinct types of social networks among older adults, with membership in these types varying by age, gender, marital status, race/ethnicity, education, mental health, and birth cohort.
INNOVATION IN AGING
(2022)
Article
Gerontology
Amilcar Matos-Moreno, Ashton M. Verdery, Carlos F. Mendes de Leon, Vivianna M. De Jesus-Monge, Alexis R. Santos-Lozada
Summary: Puerto Rico is experiencing rapid population aging due to long-running fertility and mortality trends, as well as high levels of outmigration of working-age adults. Policymakers and government leaders need to plan for this unconventional population aging, taking into account its impact on government services, economic prospects, social support networks, caregiving dynamics, and public health policies.
Article
Geriatrics & Gerontology
Dana A. Glei, Carlos F. Mendes de Leon, Chioun Lee, Maxine Weinstein
Summary: The study suggests that worse cognitive function is associated with premature mortality, even at working ages. This highlights the importance of cognitive function as an early warning sign for premature death.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Pankaja Desai, Kristin R. Krueger, Carlos Mendes de Leon, Robert S. Wilson, Denis A. Evans, Kumar B. Rajan
Summary: This study investigates the impact of depressive symptoms and glial fibrillary acid protein (GFAP) concentrations on cognitive functioning. The results show that depressive symptoms and high GFAP concentrations contribute to cognitive decline, while depressive symptoms and low GFAP concentrations have a smaller effect.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Boya Zhang, Kenneth M. Langa, Jennifer Weuve, Jennifer D'Souza, Adam Szpiro, Jessica Faul, Carlos Mendes de Leon, Joel D. Kaufman, Lynda Lisabeth, Richard A. Hirth, Sara D. Adar
Summary: This study investigated whether hypertension and stroke serve as mediators and modifiers of the association between PM2.5 and incident dementia. The findings suggest that although hypertension may enhance individuals' susceptibility to air pollution, hypertension and stroke do not significantly mediate or modify the association of PM2.5 with dementia.
Article
Gerontology
Talha Ali, Michael R. Elliott, Toni C. Antonucci, Belinda L. Needham, Jon Zelner, Carlos F. Mendes de Leon
Summary: Findings on the effect of network size and support on functional health are mixed. In this study, we examined the association between network types, which incorporate multiple network characteristics, and functional health in late life. Results showed that older adults in small, restricted, high contact networks had fewer disabilities but worse mobility.
JOURNAL OF AGING AND HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Farah Kader, Latifa Bazzi, Lilah Khoja, Fatima Hassan, Carlos Mendes de Leon
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2020)
Article
Public, Environmental & Occupational Health
Samantha Horn, Yana Litovsky, George Loewenstein
Summary: This study suggests that curiosity can be a useful tool in increasing demand for and engagement with aversive health information. By manipulating curiosity through various methods, researchers found that participants were more likely to view and engage with information about their drinking habits, cancer risk, and the sugar content in drinks. Overall, curiosity prompts provide a simple and effective way to increase engagement with aversive health information.
SOCIAL SCIENCE & MEDICINE
(2024)
Article
Public, Environmental & Occupational Health
Sandra Gillner
Summary: Despite high expectations, the extensive and rapid adoption of AI in medical diagnostics has not been realized. This study investigates the perception and navigation of AI providers in complex healthcare systems, revealing their self-organization to increase adaptability and the practices utilized to mitigate tensions within the healthcare subsystems.
SOCIAL SCIENCE & MEDICINE
(2024)
Article
Public, Environmental & Occupational Health
Fabian Duartea, Alvaro Jimenez-Molina
Summary: This study found that violence related to social protest has a significant impact on depressive symptoms, leading to an increase in depression among the population in Chile. The effect varies by gender and age, with a stronger influence on men and young adults.
SOCIAL SCIENCE & MEDICINE
(2024)
Article
Public, Environmental & Occupational Health
Nick Graetz, Carl Gershenson, Sonya R. Porter, Danielle H. Sandler, Emily Lemmerman, Matthew Desmond
Summary: Investments in stable, affordable housing may be an important tool for improving population health. This study, using administrative data, found that high rent burden, increases in rent burden during midlife, and evictions were associated with increased mortality.
SOCIAL SCIENCE & MEDICINE
(2024)
Article
Public, Environmental & Occupational Health
Wan Wei
Summary: This study explores the phenomenon of other patient participation in Traditional Chinese Medicine (TCM), uncovering the various roles that third parties can assume during medical interactions. The findings contribute to existing research on patient resistance and triadic medical interactions, providing insights into the dynamics and implications of third-party involvement in medical consultations.
SOCIAL SCIENCE & MEDICINE
(2024)
Article
Public, Environmental & Occupational Health
Harry Scarbrough, Katie Rose M. Sanfilippo, Alexandra Ziemann, Charitini Stavropoulou
Summary: This paper examines the contribution of pilot implementation studies to the wider spread and sustainability of innovation in healthcare systems. Through an empirical examination of an innovation intermediary organization in the English NHS, the study finds that their work in mobilizing pilot-based evidence involves configuring to context, transitioning evidence, and managing the transition. The findings contribute to theory by showing how intermediary roles can support the effective transitioning of pilot-based evidence, leading to more widespread adoption and sustainability of innovation.
SOCIAL SCIENCE & MEDICINE
(2024)
Article
Public, Environmental & Occupational Health
Marta Seiz, Leire Salazar, Tatiana Eremenko
Summary: This study examines the impact of maternal educational selection on birth outcomes during an economic recession, and finds that more educated mothers are more likely to give birth during high unemployment periods. Additionally, maternal education mitigates the adverse effects of unemployment on birth outcomes and is consistently associated with better perinatal health.
SOCIAL SCIENCE & MEDICINE
(2024)
Article
Public, Environmental & Occupational Health
Jingyuan Shi, Hye Kyung Kim, Charles T. Salmon, Edson C. Tandoc Jr, Zhang Hao Goh
Summary: This study examines the influence of individual and collective norms on COVID-19 vaccination intention across eight Asian countries. The findings reveal nuanced patterns of how individual and collective social norms influence health behavioral decisions, depending on the degree of cultural tightness-looseness.
SOCIAL SCIENCE & MEDICINE
(2024)
Article
Public, Environmental & Occupational Health
Elliot Friedman, Melissa Franks, Elizabeth Teas, Patricia A. Thomas
Summary: This study found that positive relations with others have a significant impact on functional limitations and longevity in aging adults, independent of social integration and social support.
SOCIAL SCIENCE & MEDICINE
(2024)
Article
Public, Environmental & Occupational Health
Zhuolin Pan, Yuqi Liu, Ye Liu, Ziwen Huo, Wenchao Han
Summary: This study examines the effects of age-friendly neighbourhood environment and functional abilities on life satisfaction among older adults in urban China. The findings highlight the importance of transportation, housing, and social and physical environment factors in influencing functional abilities and life satisfaction. The study provides valuable insights for policymakers in enhancing older adults' life satisfaction in the Chinese urban context.
SOCIAL SCIENCE & MEDICINE
(2024)
