A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation

Will we ever have better glucocorticoids?

(2018) Frank Buttgereit et al.   CLINICAL IMMUNOLOGY

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

(2018) Marlies Ballegeer et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile

(2018) Lena Ripa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epidemiology of Asthma and Influence of Ethnicity

(2018) Theo Moraes et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits improved transrepression/transactivation dissociation

(2017) Takafumi Kurimoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Involvement of the Glucocorticoid Receptor in Pro-inflammatory Transcription Factor Inhibition by Daucane Esters from Laserpitium zernyi

(2017) Višnja Popović et al.   JOURNAL OF NATURAL PRODUCTS

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

The nature of the GRE influences the screening for GR-activity enhancing modulators

(2017) Karen Dendoncker et al.   PLoS One

Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators

(2016) Martin Hemmerling et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Natural Mutation in Helix 5 of the Ligand Binding Domain of Glucocorticoid Receptor Enhances Receptor-Ligand Interaction

(2016) Henry Reyer et al.   PLoS One

Activation of the Glucocorticoid Receptor in Acute Inflammation: the SEDIGRAM Concept

(2016) Karolien De Bosscher et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The glucocorticoid receptor in inflammatory processes: transrepression is not enough

(2015) Sabine Hübner et al.   BIOLOGICAL CHEMISTRY

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

(2015) L Dejager et al.   Mucosal Immunology

Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds

(2015) Nora Sundahl et al.   PHARMACOLOGY & THERAPEUTICS

Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands

(2015) Christopher F. Rider et al.   PLoS One

A Plant-Derived Ligand Favoring Monomeric Glucocorticoid Receptor Conformation with Impaired Transactivation Potential Attenuates Collagen-Induced Arthritis

(2014) P. Dewint et al.   JOURNAL OF IMMUNOLOGY

Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor

(2014) Diego M. Presman et al.   PLOS BIOLOGY

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1

(2013) Karolien De Bosscher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

New Insights into the Anti-inflammatory Mechanisms of Glucocorticoids: An Emerging Role for Glucocorticoid-Receptor-Mediated Transactivation

(2013) Sofie Vandevyver et al.   ENDOCRINOLOGY

Anti-inflammatory Effects of Mapracorat, a Novel Selective Glucocorticoid Receptor Agonist, Is Partially Mediated by MAP Kinase Phosphatase-1 (MKP-1)

(2012) Thomas R. Vollmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation

(2012) Sofie Vandevyver et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice

(2012) M N Silverman et al.   MOLECULAR PSYCHIATRY

Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1

(2011) Eugénie Joanny et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Antagonists But Not Partial Agonists of Glucocorticoid Receptor Ligands Show Substantial Side Effect Dissociation

(2011) Xiao Hu et al.   ENDOCRINOLOGY

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages

(2011) Anna Kleiman et al.   FASEB JOURNAL

Tumor Necrosis Factor Inhibits Glucocorticoid Receptor Function in Mice

(2011) Tom Van Bogaert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the Trail of the Glucocorticoid Receptor: Into the Nucleus and Back

(2011) Sofie Vandevyver et al.   TRAFFIC

Glucocorticoids inhibit IL-1β-induced GM-CSF expression at multiple levels: roles for the ERK pathway and repression by MKP-1

(2010) Robert Newton et al.   BIOCHEMICAL JOURNAL

Discovery of quinolines as selective glucocorticoid receptor agonists

(2010) Stefan Jaroch et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor

(2010) Raoul Frijters et al.   BMC GENOMICS

Glucocorticoids Suppress Bone Formation by Attenuating Osteoblast Differentiation via the Monomeric Glucocorticoid Receptor

(2010) Alexander Rauch et al.   Cell Metabolism

Targeting inflammation using selective glucocorticoid receptor modulators

(2010) Karolien De Bosscher et al.   CURRENT OPINION IN PHARMACOLOGY

Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases

(2009) H Schäcke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Abrogation of Glucocorticoid Receptor Dimerization Correlates with Dissociated Glucocorticoid Behavior of Compound A

(2009) Steven Robertson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations

(2009) Guillaume A. Schoch et al.   JOURNAL OF MOLECULAR BIOLOGY

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

(2009) S. H. Meijsing et al.   SCIENCE

The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene

(2008) David S. Waddell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

LGD-5552, an Antiinflammatory Glucocorticoid Receptor Ligand with Reduced Side Effects,in Vivo

(2008) Francisco J. López et al.   ENDOCRINOLOGY