Article
Biochemistry & Molecular Biology
Minfeng Ying, Duo You, Xiaobing Zhu, Limeng Cai, Siying Zeng, Xun Hu
Summary: This study reveals that lactate and glutamine can support NADPH production through pathways involving IDH1 and ME1 under glucose-deprived conditions. These findings demonstrate the metabolic plasticity and flexibility of cancer cells in adapting to nutritional stress, providing viable methods for cancer cells to resist glucose starvation.
Article
Veterinary Sciences
Nile Wuri, Hongchao Gou, Bin Zhang, Menglu Wang, Songqi Wang, Weixiao Zhang, Haiyan He, Xuelei Fan, Chunhong Zhang, Zhicheng Liu, Letu Geri, Haiyan Shen, Jianfeng Zhang
Summary: Porcine epidemic diarrhea virus (PEDV) is a deadly pathogen causing significant economic losses in pig herds worldwide. This study reveals the key role of glucose, glutamine, and lactate in PEDV replication, independent of genotype and MOI. The findings suggest lactate as a promising cell culture additive to improve vaccine production and develop novel antiviral strategies.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Yulia Dembitskaya, Charlotte Piette, Sylvie Perez, Hugues Berry, Pierre J. Magistretti, Laurent Venance
Summary: The study shows that glucose and lactate play different roles in memory engram and neural computation. Lactate is important for high-stimulation load activity patterns and high attentional load in cognitive tasks, while glucose is sufficient for less demanding neural computation and learning tasks.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Hyeon-Young Min, Jiyeon Hwang, Yuna Choi, Young-Hwan Jo
Summary: The overexpression of lactate receptor HCAR1 in interscapular brown adipose tissue (BAT) of male DIO mice promotes glucose uptake, reduces lipolysis, prevents weight gain, improves glucose tolerance and insulin sensitivity. Activation of HCAR1 in BAT restores body weight and metabolic health in obese individuals, suggesting a potential therapeutic target for controlling obesity and glucose metabolism.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Bhadra S. Kumar, Nagavarshini Mayakkannan, N. Sowmya Manojna, V. Srinivasa Chakravarthy
Summary: Research on Artificial Neurovascular Networks demonstrates that training the vascular network alongside the neural network leads to higher performance and lower energy consumption. As the network size increases, the relationship between energy consumption dynamics and classification accuracy approaches a fixed-point attractor in the per capita energy consumption vs. classification accuracy space.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Inge Oudaert, Arne Van der Vreken, Anke Maes, Elke De Bruyne, Kim De Veirman, Karin Vanderkerken, Eline Menu
Summary: This article discusses the metabolic adaptations of Multiple Myeloma (MM) cells in a hypoxic environment and how targeted treatments can block tumor progression.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Caroline R. Bartman, Tara TeSlaa, Joshua D. Rabinowitz
Summary: The article provides a detailed review of techniques for measuring metabolic fluxes in intact mammals and emphasizes the importance of measuring metabolism in vivo. Researchers studying glucose homeostasis have developed strategies that have been strengthened by recent advances in metabolomics technologies, with promising avenues for future application. The broader application of these methods has the potential to accelerate biomedical progress given the significant importance of metabolism to health and disease.
Article
Marine & Freshwater Biology
Charlotte H. Wilson, Sarah J. Nancollas, Molly L. Rivers, John I. Spicer, Iain J. McGaw
Summary: This study investigated the effect of different handling procedures on the acute physiological responses of green shore crab, finding that oxygen consumption and hemolymph glucose and L-lactate concentrations were elevated post-handling. Differences between light and severe handling treatments showed that vibration was a major contributor to the stress response. Even gentle handling without physical touching and minimal visual and vibrational stimuli still evoked a stress response in crabs, supporting a recommendation for a settling time of at least 12 hours before experimental procedures are initiated.
MARINE AND FRESHWATER BEHAVIOUR AND PHYSIOLOGY
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Kanika Dheman, Alkinoos Sariglou, Michele Magno
Summary: Non-invasive sweat glucose and lactate monitoring using wearable electrochemical sensors offers comfortable and continuous tracking, overcoming the limitations of conventional blood sampling methods. This study focuses on investigating and characterizing the properties of glucose and lactate electrochemical sensors, including temperature dependence and durability. The research demonstrates that the sensors can detect glucose and lactate within specific concentration ranges and provides insights into their sensitivity and reproducibility.
2023 9TH INTERNATIONAL WORKSHOP ON ADVANCES IN SENSORS AND INTERFACES, IWASI
(2023)
Article
Biophysics
Ana Sofia Oliveira, Catia Vicente Vaz, Ana Silva, Sara Correia, Raquel Ferreira, Luiza Breitenfeld, Jose Martinez-de-Oliveira, Rita Palmeira-de-Oliveira, Claudia Pereira, Maria Teresa Cruz, Ana Palmeira-de-Oliveira
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2020)
Review
Chemistry, Medicinal
Henrique J. Cardoso, Tiago M. A. Carvalho, Lara R. S. Fonseca, Marilia Figueira, Catia V. Vaz, Silvia Socorro
Summary: Prostate cancer metabolism is becoming increasingly important, with metabolic reprogramming and activation of specific pathways playing a crucial role in therapy. Glucose, lipids, and glutamine are essential for PCa cell survival and growth.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Oncology
Henrique J. Cardoso, Marilia Figueira, Catia V. Vaz, Tiago M. A. Carvalho, Luis A. Bras, Patricia A. Madureira, Paulo J. Oliveira, Vilma A. Sardao, Silvia Socorro
Summary: The study revealed that androgens play a crucial role in regulating the metabolism of prostate cancer cells, especially in CRPC cells. Inhibition of glutaminolysis with BPTES reduced the viability and migration of PCa cells, with a more significant effect observed in CRPC cells. Targeting glutaminase may offer a promising approach for the treatment of CRPC.
Article
Multidisciplinary Sciences
A. Silva, A. S. Oliveira, C. V. Vaz, S. Correia, R. Ferreira, L. Breitenfeld, J. Martinez-de-Oliveira, R. Palmeira-de-Oliveira, C. M. F. Pereira, A. Palmeira-de-Oliveira, M. T. Cruz
SCIENTIFIC REPORTS
(2020)
Review
Reproductive Biology
Mariana Feijo, Roberta V. L. Martins, Silvia Socorro, Luisa Pereira, Sara Correia
Summary: Endocrine-disrupting chemical Vinclozolin was found to decrease sperm quality parameters and testicular/epididymal weight in exposed animals. Exposure length, dose, and time point influenced the results, with overall robustness observed in sensitivity analysis despite moderate/high heterogeneity. Studies included were of good quality, with data supporting the disruption of spermatogenic output and male fertility by Vinclozolin exposure.
BIOLOGY OF REPRODUCTION
(2021)
Review
Biochemistry & Molecular Biology
Lara R. S. Fonseca, Goncalo R. Silva, Angelo Luis, Henrique J. Cardoso, Sara Correia, Cilia V. Vaz, Ana P. Duarte, Silvia Socorro
Summary: Sweet cherries are rich in phenolic compounds and have a wide range of effects on important events in the carcinogenic process, especially in metabolic reprogramming. Research suggests that sweet cherries have potential anti-cancer effects against oxidative stress, chronic inflammation, deregulated cell proliferation and apoptosis, invasion and metastization, and metabolic alterations.
Article
Medicine, General & Internal
Ines Mateus, Carina Prip-Buus
Summary: Hydrogen sulphide (H2S) was previously seen as a toxic gas and environmental pollutant, but is now recognized as the third mammalian gasotransmitter with key roles in inflammation and diseases. In the liver, H2S plays a crucial role in glucose and lipid metabolism and may have implications in chronic liver diseases. Further research is needed to understand the physiological relevance of mitochondrial H2S oxidation and its impact on liver energy homeostasis.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Chemistry, Analytical
Josue Carvalho, Jessica Lopes-Nunes, Joana Figueiredo, Tiago Santos, Andre Miranda, Micaela Riscado, Fani Sousa, Ana Paula Duarte, Silvia Socorro, Candida Teixeira Tomaz, Mafalda Felgueiras, Rui Teixeira, Conceicao Faria, Carla Cruz
Summary: The study aimed to develop a molecular beacon-based detection assay for SARS-CoV-2, focusing on ORF1ab and S gene detection, proposing a two-stage COVID-19 testing strategy. The results showed a correlation between high fluorescence levels and low Ct values, indicating an association between viral load and increased MB fluorescence.
Article
Biochemistry & Molecular Biology
Sandra M. Rocha, Daniel Nascimento, Rafaella S. Coelho, Ana Margarida Cardoso, Luis A. Passarinha, Silvia Socorro, Claudio J. Maia
Summary: This study aimed to evaluate the sensitivity of prostate cancer (PCa) cells to taxane-based drugs in response to STEAP1 gene expression. The results showed that STEAP1 knockdown or treatment with taxane-based drugs significantly reduced the viability and survival pathways of PCa cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Information Systems
Sandra M. Rocha, Silvia Socorro, Luis A. Passarinha, Claudio J. Maia
Summary: This study reveals that the expression levels of STEAP genes vary significantly in human cancers, which may be related to patients' prognosis.
Article
Reproductive Biology
Ana M. S. Silva, Silvia Socorro, Ana Hurtado de Llera, Catia V. Vaz, Sara Correia, Claudio J. Maia