Decreased signalling of EphA4 improves functional performance and motor neuron survival in the SOD1G93A ALS mouse model

Antisense-mediated reduction of EphA4 in the adult CNS does not improve the function of mice with amyotrophic lateral sclerosis

(2018) Karen K. Ling et al.   NEUROBIOLOGY OF DISEASE

Neuromuscular Junction Dismantling in Amyotrophic Lateral Sclerosis

(2017) Valentina Cappello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bifunctional role of ephrin A1-Eph system in stimulating cell proliferation and protecting cells from cell death through the attenuation of ER stress and inflammatory responses in bovine mammary epithelial cells

(2017) Minkyung Kang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The identification of a novel isoform of EphA4 and ITS expression in SOD1 G93A mice

(2017) Jing Zhao et al.   NEUROSCIENCE

Inflammation and neuronal death in the motor cortex of the wobbler mouse, an ALS animal model

(2015) Carolin Dahlke et al.   Journal of Neuroinflammation

Role of EphA4 signaling in the pathogenesis of amyotrophic lateral sclerosis and therapeutic potential of traditional Chinese medicine rhynchophylline

(2015) Kenji Hashimoto   PSYCHOPHARMACOLOGY

Dynamic Principle for Designing Antagonistic/Agonistic Molecules for EphA4 Receptor, the Only Known ALS Modifier

(2014) Haina Qin et al.   ACS Chemical Biology

Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial

(2014) Anne-Marie Wills et al.   LANCET

Modifying expression of EphA4 and its downstream targets improves functional recovery after stroke

(2013) Robin Lemmens et al.   HUMAN MOLECULAR GENETICS

Acute Delivery of EphA4-Fc Improves Functional Recovery after Contusive Spinal Cord Injury in Rats

(2013) Mark Damien Spanevello et al.   JOURNAL OF NEUROTRAUMA

Controversies and priorities in amyotrophic lateral sclerosis

(2013) Martin R Turner et al.   LANCET NEUROLOGY

Therapeutic AAV9-mediated Suppression of Mutant SOD1 Slows Disease Progression and Extends Survival in Models of Inherited ALS

(2013) Kevin D Foust et al.   MOLECULAR THERAPY

Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: The EPIC cohort

(2013) V. Gallo et al.   NEUROLOGY

EphA4 Receptor Tyrosine Kinase Is a Modulator of Onset and Disease Severity of Experimental Autoimmune Encephalomyelitis (EAE)

(2013) Kathryn M. Munro et al.   PLoS One

Characterization of early pathogenesis in the SOD1G93Amouse model of ALS: part I, background and methods

(2013) Sharon Vinsant et al.   Brain and Behavior

Eph/Ephrin Signaling in Injury and Inflammation

(2012) Mark G. Coulthard et al.   AMERICAN JOURNAL OF PATHOLOGY

Impaired blood–brain/spinal cord barrier in ALS patients

(2012) Svitlana Garbuzova-Davis et al.   BRAIN RESEARCH

EphA/ephrin-A signaling is critically involved in region-specific apoptosis during early brain development

(2012) E Park et al.   CELL DEATH AND DIFFERENTIATION

Changes in the astrocytic aquaporin-4 and inwardly rectifying potassium channel expression in the brain of the amyotrophic lateral sclerosis SOD1G93Arat model

(2012) Danijela Bataveljić et al.   GLIA

TrkA Gene Ablation in Basal Forebrain Results in Dysfunction of the Cholinergic Circuitry

(2012) E. Sanchez-Ortiz et al.   JOURNAL OF NEUROSCIENCE

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

(2012) Annelies Van Hoecke et al.   NATURE MEDICINE

Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors

(2012) Gael Barthet et al.   NEUROBIOLOGY OF AGING

Differential Gene Expression in the EphA4 Knockout Spinal Cord and Analysis of the Inflammatory Response Following Spinal Cord Injury

(2012) Kathryn M. Munro et al.   PLoS One

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

(2011) Jari Rossi et al.   Cell Metabolism

EphA4 Blockers Promote Axonal Regeneration and Functional Recovery Following Spinal Cord Injury in Mice

(2011) Yona Goldshmit et al.   PLoS One

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

(2010) Jeffrey D. Rothstein   ANNALS OF NEUROLOGY

Significance of behavioural tests in a transgenic mouse model of amyotrophic lateral sclerosis (ALS)

(2010) Sarah Knippenberg et al.   BEHAVIOURAL BRAIN RESEARCH

Glutamate Transporters and the Excitotoxic Path to Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis

(2009) Emily Foran et al.   ANTIOXIDANTS & REDOX SIGNALING

Impaired blood–brain and blood–spinal cord barriers in mutant SOD1-linked ALS rat

(2009) Charles Nicaise et al.   BRAIN RESEARCH

Inflammation in ALS and SMA: Sorting out the good from the evil

(2009) Dimitra Papadimitriou et al.   NEUROBIOLOGY OF DISEASE

Aquaporin-4 Overexpression in Rat ALS Model

(2008) Charles Nicaise et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesis

(2008) Céline Furne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

(2008) Zhihui Zhong et al.   NATURE NEUROSCIENCE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON