Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

(2017) Tariq Afroz et al.   Nature Communications

Prion-like propagation as a pathogenic principle in frontotemporal dementia

(2016) Eva-Maria Hock et al.   JOURNAL OF NEUROCHEMISTRY

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

(2016) Ian R. A. Mackenzie et al.   JOURNAL OF NEUROCHEMISTRY

Tau physiology and pathomechanisms in frontotemporal lobar degeneration

(2016) Liviu-Gabriel Bodea et al.   JOURNAL OF NEUROCHEMISTRY

Detection of protein–protein interactions at the septin collar in Saccharomyces cerevisiae using a tripartite split-GFP system

(2016) Gregory C. Finnigan et al.   MOLECULAR BIOLOGY OF THE CELL

Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases

(2016) Gianluigi Forloni et al.   MOVEMENT DISORDERS

A scalable strategy for high-throughput GFP tagging of endogenous human proteins

(2016) Manuel D. Leonetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Biology of Prions and Prionoids: A Status Report

(2016) Adriano Aguzzi et al.   TRENDS IN CELL BIOLOGY

Versatile protein tagging in cells with split fluorescent protein

(2016) Daichi Kamiyama et al.   Nature Communications

Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss

(2016) J. Di et al.   Scientific Reports

Mirror movements in progressive hemifacial atrophy

(2015) Rajesh Verma et al.   Annals of Indian Academy of Neurology

TDP-43 is intercellularly transmitted across axon terminals

(2015) Marisa S. Feiler et al.   JOURNAL OF CELL BIOLOGY

Single-molecule spectroscopy of protein conformational dynamics in live eukaryotic cells

(2015) Iwo König et al.   NATURE METHODS

Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?

(2015) Anaïs Aulas et al.   Frontiers in Cellular Neuroscience

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants

(2015) Laura Tosatto et al.   Scientific Reports

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

(2014) Lina Wang et al.   CURRENT BIOLOGY

A new split-GFP-based probe reveals DJ-1 translocation into the mitochondrial matrix to sustain ATP synthesis upon nutrient deprivation

(2014) Tito Calì et al.   HUMAN MOLECULAR GENETICS

Dimerization, Oligomerization, and Aggregation of Human Amyotrophic Lateral Sclerosis Copper/Zinc Superoxide Dismutase 1 Protein Mutant Forms in Live Cells

(2014) Jiho Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence of Native α-Synuclein Conformers in the Human Brain

(2014) Neal Gould et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

(2014) Jing L Guo et al.   NATURE MEDICINE

Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones

(2014) J. Robin Highley et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Interaction Analysis through Proteomic Phage Display

(2014) Gustav N. Sundell et al.   Biomed Research International

In vivo interactions of TTDA mutant proteins within TFIIH

(2013) J. Nonnekens et al.   JOURNAL OF CELL SCIENCE

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

A New Protein-Protein Interaction Sensor Based on Tripartite Split-GFP Association

(2013) Stéphanie Cabantous et al.   Scientific Reports

Genotype-Specific Differences between Mouse CNS Stem Cell Lines Expressing Frontotemporal Dementia Mutant or Wild Type Human Tau

(2012) Miranda E. Orr et al.   PLoS One

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

mGRASP enables mapping mammalian synaptic connectivity with light microscopy

(2011) Jinhyun Kim et al.   NATURE METHODS

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery

(2009) Brian D. Freibaum et al.   JOURNAL OF PROTEOME RESEARCH

New application of β-galactosidase complementation to monitor tau self-association

(2008) Huiping Ding et al.   JOURNAL OF NEUROCHEMISTRY