Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape

Crystal nephropathies: mechanisms of crystal-induced kidney injury

(2017) Shrikant R. Mulay et al.   Nature Reviews Nephrology

Crystal Formation in Inflammation

(2016) Bernardo S. Franklin et al.   Annual Review of Immunology

Crystallopathies

(2016) Shrikant R. Mulay et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis

(2016) Shrikant R. Mulay et al.   Nature Communications

PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling

(2015) Jyaysi Desai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis

(2014) Conor J. Kearney et al.   FEBS Journal

Lung Injury Induced by TiO2 Nanoparticles Depends on Their Structural Features: Size, Shape, Crystal Phases, and Surface Coating

(2014) Jiangxue Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Silica Particle Size on Macrophage Inflammatory Responses

(2014) Toshimasa Kusaka et al.   PLoS One

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macropinocytosis is the Major Mechanism for Endocytosis of Calcium Oxalate Crystals into Renal Tubular Cells

(2013) Rattiyaporn Kanlaya et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Particle-size-dependent cytokine responses and cell damage induced by silica particles and macrophages-derived mediators in endothelial cell

(2013) Yi Rong et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Mechanistic Aspects of Inflammation and Clinical Management of Inflammation in Acute Gouty Arthritis

(2013) Bruce N. Cronstein et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Molecular mechanisms of crystal-related kidney inflammation and injury. Implications for cholesterol embolism, crystalline nephropathies and kidney stone disease

(2013) S. R. Mulay et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Nrf2 signalling promotes ex vivo tubular epithelial cell survival and regeneration via murine double minute (MDM)-2

(2013) Jan H. Hagemann et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Inflammation and gene expression in the rat lung after instillation of silica nanoparticles: Effect of size, dispersion medium and particle surface charge

(2013) David M. Brown et al.   TOXICOLOGY LETTERS

Recognition of Bacteria by Inflammasomes

(2012) Jakob von Moltke et al.   Annual Review of Immunology

Colourful death: Six-parameter classification of cell death by flow cytometry—Dead cells tell tales

(2012) Luis E. Munoz et al.   AUTOIMMUNITY

Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion

(2012) Shrikant R. Mulay et al.   JOURNAL OF CLINICAL INVESTIGATION

Silicosis

(2012) Chi Chiu Leung et al.   LANCET

Size dependent induction of proinflammatory cytokines and cytotoxicity of particulate beta-tricalciumphosphate in vitro

(2011) Tobias Lange et al.   BIOMATERIALS

Basic calcium phosphate crystals induce NLRP3 inflammasome activation: The in vitro and in vivo face to face

(2011) H.-K. Ea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells

(2010) Meike Winter et al.   Nanotoxicology

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE