Review
Biochemistry & Molecular Biology
Christina Bogensperger, Julia Hofmann, Franka Messner, Thomas Resch, Andras Meszaros, Benno Cardini, Annemarie Weissenbacher, Rupert Oberhuber, Jakob Troppmair, Dietmar ofner, Stefan Schneeberger, Theresa Hautz
Summary: Transplantation is limited by the shortage of healthy donor organs, but ex situ machine perfusion has the potential to expand the donor pool. Mesenchymal stem cells are considered as a tool with the potential to improve organs, but clinical benefits have not been conclusively demonstrated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Amanpreet Kaur Bains, Lena Behrens Wu, Jennifer Riviere, Sandra Rother, Valentina Magno, Jens Friedrichs, Carsten Werner, Martin Bornhaeuser, Katharina S. Goetze, Michael Cross, Uwe Platzbecker, Manja Wobus
Summary: Myelodysplastic syndromes (MDS) are a heterogeneous group of blood malignancies with specific features and a high risk of progression to acute myeloid leukemia. This study found that MSC-derived extracellular matrix (ECM) plays an important role in MDS, with structural alterations observed in MDS ECM and a potential involvement of glycosaminoglycans (GAGs) in this process.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell & Tissue Engineering
Cong Zhang, Xiaohong Zhang, Min Zhang
Summary: Exosomes derived from bone marrow mesenchymal stem cells may ameliorate diabetic salivary gland complications by inhibiting TGF beta, Smad2 and Smad3 levels and improving salivary gland function, leading to reduced blood sugar levels and improved serum amylase and salivary IgA levels.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Claudia Griselda Cardenas-Leon, Kristina Maemets-Allas, Mariliis Klaas, Katre Maasalu, Viljar Jaks
Summary: This study investigated the role of sweat glands in the pathogenesis of Dupuytren's contracture (DC) through proteomic analysis and immunofluorescence microscopy. The researchers found that a fraction of sweat gland epithelium underwent epithelial-mesenchymal transition, and increased connective tissue growth factor expression in DC sweat glands had both autocrine and paracrine effects in sustaining DC formation and inducing pathological changes in DC-associated sweat glands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Jinkui Wang, Mujie Li, Liming Jin, Peng Guo, Zhaoxia Zhang, Chenghao Zhanghuang, Xiaojun Tan, Tao Mi, Jiayan Liu, Xin Wu, Guanghui Wei, Dawei He
Summary: Osteosarcoma is a bone tumor with a high incidence in children and adolescents. The low production of exosomes hinders its development as a drug carrier, but exosome mimetics (EMs) have been developed as an alternative with good drug delivery performance. In this study, EMs were used to encapsulate doxorubicin (EM-Dox) for the treatment of osteosarcoma, and it showed significantly stronger tumor inhibition activity and fewer side effects compared to free doxorubicin. This novel biological nanomedicine system provides a promising opportunity for the development of precision medicine for osteosarcoma.
Article
Engineering, Biomedical
Yanlun Zhu, Shuai Deng, Zhijie Ma, Lingzhi Kong, Haiyan Li, Hon Fai Chan
Summary: The study investigated the effect of Akermanite/sodium alginate hydrogel on in vivo inflammatory response and bone regeneration cells. The results suggest that the hydrogel can modulate the immune environment at the implantation site and subsequently recruit BMSCs, accelerating new bone formation.
BIOMEDICAL MATERIALS
(2021)
Article
Respiratory System
Davide Treggiari, Karina Kleinfelder, Marina Bertini, Gloria Tridello, Arianna Fedrigo, Emily Pintani, Patrizia Iansa, Antonella Casiraghi, Paola Minghetti, Marco Cipolli, Claudio Sorio, Paola Melotti
Summary: Optical measurement of sweat secretion can discriminate CF patients from healthy individuals by comparing the sweat rate in C-phase and M-phase. Sweat droplet number in C-phase is a statistically significant predictor for detecting the effects of CFTR-targeted therapy. This method is more sensitive than using the C/M ratio and suitable for monitoring the effects of CFTR modulators.
JOURNAL OF CYSTIC FIBROSIS
(2021)
Article
Biochemistry & Molecular Biology
Zun Wang, Xiaohua Li, Junxiao Yang, Yun Gong, Huixi Zhang, Xiang Qiu, Ying Liu, Cui Zhou, Yu Chen, Jonathan Greenbaum, Liang Cheng, Yihe Hu, Jie Xie, Xucheng Yang, Yusheng Li, Martin R. Schiller, Yiping Chen, Lijun Tan, Si-Yuan Tang, Hui Shen, Hong-Mei Xiao, Hong-Wen Deng
Summary: This study utilized single-cell RNA sequencing to identify distinct subpopulations of BM-MSCs in humans, shedding light on their cellular heterogeneity and roles in maintaining bone homeostasis, as well as potential novel markers for BM-MSC purification.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell & Tissue Engineering
Kenichi Ogata, Mayu Matsumura-Kawashima, Masafumi Moriyama, Tatsuya Kawado, Seiji Nakamura
Summary: The study suggests that DPSC-CM could be an effective therapy for SS-induced hyposalivation by reducing the number of inflammatory cytokines and regulating the local inflammatory microenvironment in the SMGs.
REGENERATIVE THERAPY
(2021)
Article
Materials Science, Biomaterials
Zhenhua Zhao, Mang Wang, Fei Shao, Ge Liu, Junlei Li, Xiaowei Wei, Xiuzhi Zhang, Jiahui Yang, Fang Cao, Qiushi Wang, Huanan Wang, Dewei Zhao
Summary: The study developed an integrated three-dimensional scaffold material using pTa and GNPs hydrogel, seeded with BMSCs-derived ECs to promote the formation of a stable capillary-like network. The scaffold exhibited superior biocompatibility and biomechanical properties, showing potential as a vascular tissue engineering material.
REGENERATIVE BIOMATERIALS
(2021)
Review
Biochemistry & Molecular Biology
David A. Hart, Norimasa Nakamura
Summary: After injuries to musculoskeletal tissues, an inflammatory response occurs to promote endogenous repair, but it often results in functionally inferior scar tissue. Injuries in adults no longer have the anabolic processes that contribute to growth and maturation, which can lead to degenerative conditions such as osteoarthritis. Researchers have been exploring cellular therapies, such as Platelet-rich Plasma and mesenchymal stem/medicinal signaling cells, to enhance tissue repair and regeneration. However, implanting these cells or engineered constructs into an inflammatory adult environment may compromise their potential for regeneration. Therefore, it may be necessary to neutralize the inflammatory environment and create an anabolic environment for optimal outcomes.
Article
Cell & Tissue Engineering
K. Futrega, E. Music, P. G. Robey, S. Gronthos, R. Crawford, S. Saifzadeh, T. J. Klein, M. R. Doran
Summary: The study characterized ovine BMSC and evaluated their ability to repair cartilage defects, concluding that micro-pellets manufactured from ovine articular chondrocytes were more effective than those from ovine BMSC. While ovine BMSC could form cartilage-like tissue in vitro, their effective application in cartilage repair will require successful mitigation of hypertrophy and tissue integration issues.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Gerard Rubi-Sans, Irene Cano-Torres, Soledad Perez-Amodio, Barbara Blanco-Fernandez, Miguel A. Mateos-Timoneda, Elisabeth Engel
Summary: The study focuses on using cell-derived matrix microtissues to mimic tissue conditions and promote vascularization. By seeding rat bone marrow mesenchymal stem cells on poly-lactic acid and microcarriers, cells are able to generate extracellular matrix and provide a complex environment with angiogenic potential.
Article
Endocrinology & Metabolism
Ziyi Li, Yafei Wang, Shilun Li, Yukun Li
Summary: Bone regeneration is a complex process involving the coordination of osteogenesis and osteoclastogenesis, with the balance between osteogenesis and adipogenesis of BMSCs playing a critical role. Recent studies have shown that exosomes from M2 macrophages facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis, potentially serving as a therapeutic tool for bone loss diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
Article
Multidisciplinary Sciences
Xiao-Feng Wang, Qing-Qing Fang, Bing Jia, Yan-Yan Hu, Zheng-Cai Wang, Ke-ping Yan, Sheng-Yong Yin, Zhen Liu, Wei-Qiang Tan
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Ji-Hua Xu, Wan-Yi Zhao, Qing-Qing Fang, Xiao-Feng Wang, Ding-Ding Zhang, Yan-Yan Hu, Bin Zheng, Wei-Qiang Tan
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2020)
Article
Biotechnology & Applied Microbiology
Wei Wang, Gao-feng Shu, Kong-jun Lu, Xiao-ling Xu, Min-cheng Sun, Jing Qi, Qiao-ling Huang, Wei-qiang Tan, Yong-zhong Du
JOURNAL OF NANOBIOTECHNOLOGY
(2020)
Review
Dermatology
Ding-Ding Zhang, Wan-Yi Zhao, Qing-Qing Fang, Zheng-Cai Wang, Xiao-Feng Wang, Min-Xia Zhang, Yan-Yan Hu, Bin Zheng, Wei-Qiang Tan
Summary: The clinical efficacy of fractional CO2 laser therapy in acne scars is comparable to that of non-CO2 laser therapies according to the meta-analysis findings. The duration of follow-up has little effect on the evaluation of treatment effect. More well designed randomized controlled trials and standardized evaluation criteria are needed for further analysis of combination therapy efficiency.
DERMATOLOGIC THERAPY
(2021)
Article
Dermatology
Cai-Yun Li, Xiao-Feng Wang, Hai-ying Zhou, Qing-Qing Fang, Wei-Qiang Tan
Summary: Refined tumescent liposuction-curettage with pruning in small incisions is an effective method for the treatment of axillary bromhidrosis, with satisfactory results in eliminating underarm odor and low occurrence of complications. The subjective evaluation showed the majority of patients were satisfied with the treatment outcomes, while the objective evaluation revealed successful results in most cases with few complications.
DERMATOLOGIC THERAPY
(2021)
Article
Engineering, Biomedical
Xiao-Feng Wang, Meng-Lu Li, Qing-Qing Fang, Wan-Yi Zhao, Dong Lou, Yan-Yan Hu, Jun Chen, Xiao-Zhi Wang, Wei-Qiang Tan
Summary: The study demonstrated that using chitosan-vaseline gauze combined with a flexible electrical stimulation device can promote diabetic wound healing, with high voltage monophasic pulsed current shown to be beneficial in vivo. In vitro experiments showed that high voltage monophasic pulsed current can enhance proliferation and migration of human umbilical vein endothelial cells.
BIOACTIVE MATERIALS
(2021)
Article
Medicine, Research & Experimental
Ying Hu, Qing-Wei Zhao, Zheng-Cai Wang, Qing-Qing Fang, He Zhu, Dong-Sheng Hong, Xing-Guang Liang, Dong Lou, Wei-Qiang Tan
Summary: Co-transfection of BMP2 and FGF2 via chitosan nanoparticles significantly up-regulated the mRNA and protein levels of BMP-2 and FGF2, and increased OCN and BSP gene expression, indicating enhanced osteogenesis in human ADSCs in vitro.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Xiao-Wei Wang, Qi Sun, Shi-Bin Xu, Chao Xu, Chen-Jie Xia, Qi-Ming Zhao, Hua-Hui Zhang, Wei-Qiang Tan, Lei Zhang, Shu-Dong Yao
Summary: DNA methylation signatures were identified to be significantly associated with overall survival in sarcoma patients. The 3-DNA methylation signature showed high sensitivity and specificity in predicting patient outcomes, independent of clinical characteristics, indicating its potential as a novel prognostic biomarker and therapeutic target for sarcoma patients.
Review
Biochemistry & Molecular Biology
Fa-Wei Xu, Ying-Li Lv, Yu-Fan Zhong, Ya-Nan Xue, Yong Wang, Li-Yun Zhang, Xian Hu, Wei-Qiang Tan
Summary: This review summarizes the effects of EGCG and its wound dressings on skin wound healing, including various types of EGCG-containing wound dressings and their beneficial effects at different stages of wound healing. It also explains the rationale for using EGCG to promote skin wound healing and prevent scar formation, providing a future clinical application direction.
Article
Nanoscience & Nanotechnology
Yanan Xue, Cheng Chen, Rong Tan, Jingyu Zhang, Qin Fang, Rui Jin, Xiangyu Mi, Danying Sun, Yinan Xue, Yue Wang, Rong Xiong, Haojian Lu, Weiqiang Tan
Summary: Diabetic wounds pose significant challenges in clinical treatments. In this study, by using artificial intelligence and bioinformatics, a potential therapeutic agent TSA and a potential target HDAC4 for diabetic wound healing were identified. Furthermore, a microneedle-mediated patch loaded with TSA was developed to reduce injection-caused secondary damage and showed promising results in reducing inflammation and promoting tissue regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Yong Wang, Li Chen, Dan-Yang Ren, Zi-Xuan Feng, Li-Yun Zhang, Yu-Fan Zhong, Ming-Yuan Jin, Fa-Wei Xu, Chun-Yan Feng, Yong-Zhong Du, Wei-Qiang Tan
Summary: A mussel-inspired bioactive scaffold consisting mainly of collagen and hyaluronic acid has been developed for the treatment of chronic diabetic wounds. The scaffold exhibits antioxidant and anti-inflammatory effects, promoting wound healing.
MATERIALS TODAY BIO
(2022)
Article
Multidisciplinary Sciences
Wan-Yi Zhao, Li-Yun Zhang, Zheng-Cai Wang, Qing-Qing Fang, Xiao-Feng Wang, Yong-Zhong Du, Bang-Hui Shi, Dong Lou, Gui-Da Xuan, Wei-Qiang Tan
Summary: The role of angiotensin receptor blocker in wound healing and cutaneous fibrosis, specifically losartan cream, has been studied. Chitosan and asiaticoside were added to the cream to improve its anti-scarring effect. The compound losartan cream showed the best anti-scarring effect, followed by the chitosan asiaticoside cream. The treatment inhibited the expression of TGF-beta 1, collagen, and Smads, and decreased phosphorylation of Smad, indicating its potential as an effective treatment option for scars.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Yan Zheng, Yan-Yan Hu, Wan-Yi Zhao, Xiao-Feng Wang, Qing-Qing Fang, Xiong Lv, Chun Xiang, Jian-Min Yao, Wei-Qiang Tan
Summary: Capsular contracture is a common complication of breast implants, requiring treatment such as total periprosthetic capsulectomy and new implant placement. The new pouch method offers an alternative approach, but may not be suitable for patients with minimal breast tissue.
FRONTIERS IN SURGERY
(2022)
Review
Engineering, Biomedical
Yong Wang, Yanan Xue, Tao Zhang, Qingqing Fang, Mingyuan Jin, Xiaofeng Wang, Zhengcai Wang, Yanyan Hu, Wanyi Zhao, Dong Lou, Weiqiang Tan
Summary: Oxygen is crucial for organisms' survival, and photosynthesis, as the main source of oxygen in nature, has been widely applied in biomedical research.
BIO-DESIGN AND MANUFACTURING
(2021)
Article
Biophysics
Min-Xia Zhang, Wan-Yi Zhao, Qing-Qing Fang, Xiao-Feng Wang, Chun-Ye Chen, Bang-Hui Shi, Bin Zheng, Shou-Jie Wang, Wei-Qiang Tan, Li-Hong Wu
Summary: The study successfully fabricated a new chitosan-collagen sponge dressing with good antibacterial activity and water retention, demonstrating safety towards cells and showing significant healing effects in in vivo experiments.
JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS
(2021)