Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein

Discovery of a novel inhibitor of kinesin-like protein KIFC1

(2016) W. Zhang et al.   BIOCHEMICAL JOURNAL

A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer

(2016) Pavithra L. Chavali et al.   Nature Communications

Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects

(2016) Erlei Zhi et al.   Genes

Structural Basis of New Allosteric Inhibition in Kinesin Spindle Protein Eg5

(2015) Hideshi Yokoyama et al.   ACS Chemical Biology

KIFC1 is a novel potential therapeutic target for breast cancer

(2015) Yonghe Li et al.   CANCER BIOLOGY & THERAPY

Kinesin-5 Allosteric Inhibitors Uncouple the Dynamics of Nucleotide, Microtubule, and Neck-Linker Binding Sites

(2014) Guido Scarabelli et al.   BIOPHYSICAL JOURNAL

KSP Inhibitors as Antimitotic Agents

(2014) Concepcion Perez-Melero   CURRENT TOPICS IN MEDICINAL CHEMISTRY

ThePDB_REDOserver for macromolecular structure model optimization

(2014) Robbie P. Joosten et al.   IUCrJ

Discovery and Mechanistic Study of a Small Molecule Inhibitor for Motor Protein KIFC1

(2013) Jiaquan Wu et al.   ACS Chemical Biology

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes

(2013) Ciorsdaidh A. Watts et al.   CHEMISTRY & BIOLOGY

Force generation by kinesin and myosin cytoskeletal motor proteins

(2013) F. Jon Kull et al.   JOURNAL OF CELL SCIENCE

Structural Insights into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein

(2013) Venkatasubramanian Ulaganathan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structure of the ternary Eg5–ADP–ispinesib complex

(2012) S. K. Talapatra et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

iotbx.cif: a comprehensive CIF toolbox

(2011) Richard J. Gildea et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Validation of crystallographic models containing TLS or other descriptions of anisotropy

(2010) Frank Zucker et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Loop L5 Acts as a Conformational Latch in the Mitotic Kinesin Eg5

(2010) William M. Behnke-Parks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring the Intermediate States of ADP−ATP Exchange: A Simulation Study on Eg5

(2010) Wei Zhang   JOURNAL OF PHYSICAL CHEMISTRY B

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

(2010) K. W. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A kinesin motor in a force-producing conformation

(2010) Elisabeth Heuston et al.   BMC STRUCTURAL BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mechanism of Inhibition of Human KSP byIspinesib

(2008) Latesh Lad et al.   BIOCHEMISTRY