Article
Oncology
Mohammed Jawad, Suad Ibrahim, Mayur Kumar, Charlie Burgert, Wen-Wu Li, Alan Richardson
Summary: This study tested the effect of various foods on the cytotoxic activity of pitavastatin towards ovarian cancer cells. The results showed that geranylgeraniol and certain food extracts can affect the activity of pitavastatin, potentially improving the outcome of clinical trials for cancer treatment.
Article
Oncology
Debbie Piktel, Javohn C. Moore, Sloan Nesbit, Samuel A. Sprowls, Michael D. Craig, Stephanie L. Rellick, Rajesh R. Nair, Ethan Meadows, John M. Hollander, Werner J. Geldenhuys, Karen H. Martin, Laura F. Gibson
Summary: This study investigates the effects of pitavastatin in chemo-resistant ALL cells and provides evidence for the repurposing of this drug as a potential treatment for eliminating chemoresistant tumor cells. The results demonstrate that pitavastatin inhibits the proliferation of chemo-resistant ALL cells and induces apoptosis, highlighting its potential as a therapeutic agent in the treatment of chemo-resistant ALL.
Review
Chemistry, Medicinal
Santosh Kumar Verma, Rameshwari Verma, Kothanahally S. Sharath Kumar, Laxmi Banjare, Afzal B. Shaik, Richie R. Bhandare, Kadalipura P. Rakesh, Kanchugarakoppal S. Rangappa
Summary: MRSA is becoming a major concern due to its rapid resistance development, prompting the need for novel antibiotics. The oxadiazole moiety serves as an interesting and adaptable molecular structure with potential for research and development as antibacterial agents. Studies on oxadiazole-containing derivatives as potent antibacterial agents against multidrug-resistant MRSA strains and exploring structure-activity relationships have been conducted, providing valuable insights for future drug development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Piotr Stasiak, Dominika Kazmierczak, Karol Jopek, Michal Nowicki, Marcin Rucinski, Radoslaw Januchowski
Summary: Epithelial ovarian cancer has the highest mortality due to late diagnosis and resistance to chemotherapy. MiRNA can regulate the expression of drug-resistance genes, possibly affecting the sensitivity of cancer cells to chemotherapy drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dominikay Kazmierczak, Karol Jopek, Karolina Sterzynska, Michal Nowicki, Marcin Rucinski, Radoslaw Januchowski
Summary: This study aimed to detect changes in miRNA expression levels in two cisplatin and two paclitaxel-resistant variants of the A2780 ovarian cancer cell line, and to identify miRNAs responsible for the regulation of drug-resistance genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Wei Huang, Shu Yang, Yu-Shan Cheng, Ni Sima, Wei Sun, Min Shen, John C. Braisted, Weiguo Lu, Wei Zheng
Summary: This study has discovered a new approach to restore doxorubicin sensitivity in MDR ovarian cancer by using terfenadine to inhibit the CAMKIID/CREB1 pathway, thereby reducing the expression of ABCB1 and BIRC5, and increasing doxorubicin-induced apoptosis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Carolina Maria Sassu, Innocenza Palaia, Serena Maria Boccia, Giuseppe Caruso, Giorgia Perniola, Federica Tomao, Violante Di Donato, Angela Musella, Ludovico Muzii
Summary: Ovarian cancer is the second leading cause of death in women with gynecological cancer, with poor prognosis, especially in platinum-resistant disease. Efforts have been made to define new biomarkers, with circulating biomarkers being detected non-invasively but potentially requiring expensive techniques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Huan-Ting Li, Xiaoyong Zhu
Summary: Drug resistance is a major cause of cancer chemotherapy failure, and overcoming drug resistance is essential in developing effective cancer therapeutic strategies. Quinoline-based compounds such as Anlotinib have been used in clinical practice to fight against cancers, showing potential as anticancer agents.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Asma Dilawari, Mirat Shah, Gwynn Ison, Haley Gittleman, Mallorie H. Fiero, Ankit Shah, Salaheldin S. Hamed, Junshan Qiu, Jingyu Yu, Wimolnut Manheng, Tiffany K. Ricks, Rajan Pragani, Arulvathani Arudchandran, Paresma Patel, Shadia Zaman, Arpita Roy, Shyam Kalavar, Soma Ghosh, William F. Pierce, Nam Atiqur Rahman, Shenghui Tang, Bronwyn D. Mixter, Paul G. Kluetz, Richard Pazdur, Laleh Amiri-Kordestani
Summary: On November 14, 2022, the FDA granted accelerated approval for mirvetuximab soravtansine-gynx in the treatment of a specific type of ovarian cancer. This targeted therapy is the first of its kind for this particular type of cancer and the first antibody-drug conjugate approved for ovarian cancer.
CLINICAL CANCER RESEARCH
(2023)
Review
Chemistry, Medicinal
Wang Jun, Yumin Shi, Yan Heng
Summary: Quinolone derivatives, especially fluoroquinolones, are widely prescribed antibiotics for treating bacterial infections. Combining quinolone with other antibacterial pharmacophores can target different drug resistance mechanisms. Quinolone hybrids are valuable prototypes in combating drug-resistant pathogens. This review focuses on recent articles within the past 10 years, highlighting the antibacterial activity of quinolone hybrids against drug-resistant pathogens. It also discusses structure-activity relationships, rational design, and mechanisms of action to further facilitate the development of more effective candidates.
FUTURE MEDICINAL CHEMISTRY
(2023)
Review
Oncology
Zacharias Fasoulakis, Michaela-Zoi Psarommati, Angeliki Papapanagiotou, Vasilios Pergialiotis, Antonios Koutras, Athanasios Douligeris, Anastasia Mortaki, Antonios Mihail, Marianna Theodora, Sofoklis Stavros, Defkalion Karakalpakis, Maria Papamihail, Emmanuel N. Kontomanolis, George Daskalakis, Panos Antsaklis
Summary: miRNAs play a crucial role in ovarian cancer development and progression, regulating gene expression and impacting chemoresistance. Targeting miRNAs and integrins could be a novel therapeutic strategy for inhibiting ovarian cancer progression.
Article
Reproductive Biology
Yixuan Liu, Keyu Zhu, Xiaolin Guan, Suhong Xie, Yanchun Wang, Ying Tong, Lin Guo, Hui Zheng, Renquan Lu
Summary: TTK is up-regulated in cisplatin-resistant ovarian cancer, and down-regulation of TTK can restore sensitivity to cisplatin, with the PI3K/AKT signaling pathway affected by TTK expression.
JOURNAL OF OVARIAN RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Anna Allue-Guardia, Rajagopalan Saranathan, John Chan, Jordi B. Torrelles
Summary: The review discusses the features and mechanisms of action of mycobacteriophages for treating drug-resistant tuberculosis, as well as the advantages and limitations. It also highlights the need to address key issues in the clinical application of phage therapy for drug-resistant tuberculosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Liu-Yan Su, Guang-Hui Ni, Yi-Chuan Liao, Liu-Qing Su, Jun Li, Jia-Sheng Li, Gao-Xiong Rao, Rui-Rui Wang
Summary: The study demonstrated that the combination of TA and FLC exhibited strong synergistic antifungal activity against drug-resistant C. albicans, inhibiting gene expression and reducing infectivity and resistance.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Rongxing Chen, Huarui Xue, Yazhou Xu, Tianwei Ma, Yuan Liu, Jing Zhang, Xiangkui Shi, Dong Guo
Summary: The study aimed to explore more active moxifloxacin derivatives to combat MRSA and found that the majority of the synthesized derivatives exhibited activity against MRSA strains, with one of the targets for antibacterial activity being topoisomerase IV. These derivatives may serve as useful scaffolds for the development of novel topoisomerase IV inhibitors.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Food Science & Technology
Okiemute Rosa Johnson-Ajinwo, Alan Richardson, Wen-Wu Li
Article
Multidisciplinary Sciences
Marwan Ibrahim Abdullah, Mohammed Najim Abed, Farhat Khanim, Alan Richardson
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Emily Crowley, Euphemia Leung, Johannes Reynisson, Alan Richardson
Article
Chemistry, Multidisciplinary
Louise Finch, Sarah Harris, Georgios Solomou, Jon Sen, Nikolaos Tzerakis, Richard D. Emes, Catherine S. Lane, Sarah R. Hart, Christopher F. Adams, Divya M. Chari
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Biochemistry & Molecular Biology
Nathan J. Butterworth, Falko P. Drijfhout, Phillip G. Byrne, Paul A. Keller, James F. Wallman
JOURNAL OF CHEMICAL ECOLOGY
(2020)
Article
Ecology
Nathan J. Butterworth, James F. Wallman, Falko P. Drijfhout, Nikolas P. Johnston, Paul A. Keller, Phillip G. Byrne
JOURNAL OF EVOLUTIONARY BIOLOGY
(2020)
Article
Medicine, Legal
Anika Sharma, Falko P. Drijfhout, Jeffery K. Tomberlin, Madhu Bala
Summary: The study found that the composition of hydrocarbons changes as the larvae age, allowing for the determination of the age of the hairy maggot blow fly. Different larval stages of C. rufifacies exhibit distinct hydrocarbon profiles, aiding in PMI estimations.
JOURNAL OF FORENSIC SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marcelo A. Lima, Mark Skidmore, Farhat Khanim, Alan Richardson
Summary: A high throughput 384-well assay was developed to screen for drugs that inhibit viral uptake into cells mediated by the binding to ACE2. The experiment showed that the binding of RBD protein to ACE2 receptor is time- and concentration-dependent, and is affected by specific inhibitory proteins and mutated residues.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Scott P. Davies, Courtney J. Mycroft-West, Isabel Pagani, Harriet J. Hill, Yen-Hsi Chen, Richard Karlsson, Ieva Bagdonaite, Scott E. Guimond, Zania Stamataki, Marcelo Andrade De Lima, Jeremy E. Turnbull, Zhang Yang, Elisa Vicenzi, Mark A. Skidmore, Farhat L. Khanim, Alan Richardson
Summary: The study suggests that fenofibrate and fenofibric acid may be effective in reducing SARS-CoV-2 infection by up to 70% at clinically achievable concentrations. These drugs have a history of clinical use and relatively good safety profiles, making them potential therapeutic agents that require urgent clinical evaluation for treating SARS-CoV-2 infection.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Mohammed Jawad, Suad Ibrahim, Mayur Kumar, Charlie Burgert, Wen-Wu Li, Alan Richardson
Summary: This study tested the effect of various foods on the cytotoxic activity of pitavastatin towards ovarian cancer cells. The results showed that geranylgeraniol and certain food extracts can affect the activity of pitavastatin, potentially improving the outcome of clinical trials for cancer treatment.
Article
Oncology
Suad Lateef Ibrahim, Mohammed Najim Abed, Gehad Mohamed, Joshua C. Price, Marwan Ibrahim Abdullah, Alan Richardson
Summary: Through RNAi screening, we identified a gene called branched-chain alpha-keto acid dehydrogenase kinase (BCKDK) that contributes to chemoresistance, and inhibiting BCKDK can enhance the sensitivity of breast and ovarian cancer cells to paclitaxel by suppressing the metabolism of branched-chain amino acids.
BRITISH JOURNAL OF CANCER
(2023)
Article
Agriculture, Multidisciplinary
Vasil Pirgozliev, Stephen C. C. Mansbridge, Izzy M. M. Whiting, Stephen P. P. Rose, Kristina Kljak, Amy E. E. Johnson, Falko Drijfhout, Sylwia Orczewska-Dudek, Atanas G. G. Atanasov, Teodora Mihova
Summary: This study aimed to evaluate the effects of different levels of dry Sea buckthorn (SB) berries on the growth performance, gastrointestinal tract development, jejunal histomorphology, bird antioxidant status, and caecal short-chain fatty acid concentration in female Ross 308 broiler chickens. The results showed that feeding SB did not affect bird growth performance. However, there was a linear decrease in caecal digesta butyric, acetic, and valeric acid concentrations and a decrease in crypt depth. The expression of IFNG and CD40LG responded quadratically, peaking at 6-9 g/kg dietary inclusion of SB. Other variables were not significantly affected by dietary SB inclusion. Feeding dry SB berries up to 12 g/kg of diet did not improve the zootechnical variables of healthy commercial-strain broilers in this study.
ANNALS OF APPLIED BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Mohammed Jasim Jawad, Alan Richardson
Summary: We tested the combination of pitavastatin and ivermectin in ovarian cancer cell lines and found that ivermectin showed synergy with pitavastatin in 3 cell lines, particularly in COV-318 cells. Ivermectin potentiated the reduction in cell viability and apoptosis induced by pitavastatin. These findings suggest that ivermectin may be a useful addition to pitavastatin in the treatment of ovarian cancer.
Article
Immunology
James Edwards-Smallbone, Anders L. Jensen, Lydia E. Roberts, Francis Isidore G. Totanes, Sarah R. Hart, Catherine J. Merrick
Summary: A telomere-binding protein GBP2 has been identified in the early-diverging protozoan parasite Plasmodium, which can specifically bind to G-rich telomere repeats in quadruplex form and also bind to G-rich RNA. This protein is a multifunctional DNA/RNA-binding factor in Plasmodium.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Vasil Pirgozliev, Isobel Margaret Whiting, Stephen Charles Mansbridge, Stanimir Enchev, Stephen Paul Rose, Kristina Kljak, Amy Elizabeth Johnson, Falko Drijfhout, Sylwia Orczewska-Dudek, Atanas Georgiev Atanasov
Summary: This study aimed to compare the effects of feeding broiler chickens diets containing stevia and exogenous xylanase, alone or in combination, on growth performance, dietary energy and nutrient availability, oxidative status, gastrointestinal tract development, and caecal short chain fatty acid concentration at two ambient rearing temperatures. The results showed that rearing birds at high ambient temperature reduced feed intake, while feeding stevia and xylanase improved metabolisable energy and nitrogen retention. Additionally, dietary stevia and xylanase supplementation improved hepatic antioxidant status in broilers by increasing hepatic vitamin E and carotenoids, suggesting potential benefits in counteracting oxidative stress.
CURRENT RESEARCH IN BIOTECHNOLOGY
(2021)