Synthesis and Evaluation of GM2-Monophosphoryl Lipid A Conjugate as a Fully Synthetic Self-Adjuvant Cancer Vaccine

Randomized phase III trial comparing postoperative adjuvant ganglioside GM2-KLH/QS-21 vaccination versus observation in stage II (T3-T4N0M0) melanoma: Final results of study EORTC 18961.

(2017) A. M. Eggermont et al.   JOURNAL OF CLINICAL ONCOLOGY

Recent Advance in Tumor-associated Carbohydrate Antigens (TACAs)-based Antitumor Vaccines

(2016) Danyang Feng et al.   ACS Chemical Biology

Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis

(2016) Guochao Liao et al.   ACS Central Science

Development of Globo-H Cancer Vaccine

(2015) Samuel J. Danishefsky et al.   ACCOUNTS OF CHEMICAL RESEARCH

Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ, and the Induction of Anticancer Antibodies

(2015) Zhaojun Yin et al.   CHEMBIOCHEM

Synthesis and immunological study of α-2,9-oligosialic acid conjugates as anti-group C meningitis vaccines

(2015) Guochao Liao et al.   CHEMICAL COMMUNICATIONS

Recent advances in the molecular design of synthetic vaccines

(2015) Lyn H. Jones   Nature Chemistry

Chemical Synthesis of the Repeating Unit of Type Ia Group B Streptococcus Capsular Polysaccharide

(2015) Prolay K. Mondal et al.   ORGANIC LETTERS

A fully synthetic self-adjuvanting globo H-Based vaccine elicited strong T cell-mediated antitumor immunity

(2015) Zhifang Zhou et al.   Chemical Science

Synthetic self-adjuvanting glycopeptide cancer vaccines

(2015) David M. McDonald et al.   Frontiers in Chemistry

Synthesis and evaluation of monophosphoryl lipid A derivatives as fully synthetic self-adjuvanting glycoconjugate cancer vaccine carriers

(2014) Zhifang Zhou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Adjuvant Ganglioside GM2-KLH/QS-21 Vaccination Versus Observation After Resection of Primary Tumor > 1.5 mm in Patients With Stage II Melanoma: Results of the EORTC 18961 Randomized Phase III Trial

(2013) Alexander M.M. Eggermont et al.   JOURNAL OF CLINICAL ONCOLOGY

Fully Synthetic Self-Adjuvanting Thioether-Conjugated GlycopeptideLipopeptide Antitumor Vaccines for the Induction of Complement-Dependent Cytotoxicity against Tumor Cells

(2012) Hui Cai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Development in Carbohydrate Based Anticancer Vaccines

(2012) Zhaojun Yin et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Design of Fully Synthetic, Self-Adjuvanting Vaccine Incorporating the Tumor-Associated Carbohydrate Tn Antigen and Lipoamino Acid-Based Toll-like Receptor 2 Ligand

(2012) Abu-Baker M. Abdel-Aal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbohydrate-Monophosphoryl Lipid A Conjugates Are Fully Synthetic Self-Adjuvanting Cancer Vaccines Eliciting Robust Immune Responses in the Mouse

(2011) Qianli Wang et al.   ACS Chemical Biology

Towards a Fully Synthetic MUC1-Based Anticancer Vaccine: Efficient Conjugation of Glycopeptides with Mono-, Di-, and Tetravalent Lipopeptides Using Click Chemistry

(2011) Hui Cai et al.   CHEMISTRY-A EUROPEAN JOURNAL

The total synthesis of a ganglioside Hp-s1 analogue possessing neuritogenic activity by chemoselective activation glycosylation

(2011) Yow-Fu Tsai et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and evaluation of protein conjugates of GM3 derivatives carrying modified sialic acids as highly immunogenic cancer vaccine candidates

(2011) Shichong Yu et al.   MedChemComm

Fully Synthetic Vaccines Consisting of Tumor-Associated MUC1 Glycopeptides and a Lipopeptide Ligand of the Toll-like Receptor 2

(2010) Anton Kaiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

5-N,4-O-Carbonyl-7,8,9-tri-O-chloroacetyl-Protected Sialyl Donor for the Stereoselective Synthesis of α-(2→9)-Tetrasialic Acid

(2010) Chang-Ching Lin et al.   JOURNAL OF ORGANIC CHEMISTRY

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

Increasing the Antigenicity of Synthetic Tumor-Associated Carbohydrate Antigens by Targeting Toll-Like Receptors

(2009) Sampat Ingale et al.   CHEMBIOCHEM

Immunotherapy for cancer: synthetic carbohydrate-based vaccines

(2009) Therese Buskas et al.   CHEMICAL COMMUNICATIONS

Induction of a Melanoma-Specific Antibody Response by a Monovalent, but not a Divalent, Synthetic GM2 Neoglycopeptide

(2009) S. Bay et al.   ChemMedChem

Recent development in carbohydrate-based cancer vaccines

(2009) Zhongwu Guo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

From Synthesis to Biologics: Preclinical Data on a Chemistry Derived Anticancer Vaccine

(2009) Jianglong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antitumor activity of a self-adjuvanting glyco-lipopeptide vaccine bearing B cell, CD4+ and CD8+ T cell epitopes

(2008) Ilham Bettahi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Towards a Self-Adjuvanting Multivalent B and T cell Epitope Containing Synthetic Glycolipopeptide Cancer Vaccine

(2008) Olivier Renaudet et al.   ChemMedChem

Efficient Synthesis of a Sialic Acid α(2→3)Galactose Building Block and Its Application to the Synthesis of Ganglioside GM3

(2008) Yunpeng Liu et al.   JOURNAL OF ORGANIC CHEMISTRY